Immunity, Inflammation and DiseaseBackground Since coronavirus 2019 (COVID‐19) swept the world, a variety of novel therapeutic and prevention strategies have been developed, among which nirmatrelvir–ritonavir is highly recommended.
Can Chen +7 more
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A 67-Year-Old Man with Chronic Lymphocytic Leukemia (CLL) on Maintenance Therapy with Ibrutinib with Persistent SARS-CoV-2 Infection Unresponsive to Antiviral Treatments [PDF]
Objective: Unusual clinical course Background: SARS-CoV-2 infection can persist in immunocompromised patients with hematological malignancies, despite antiviral treatment.
Cingolani, Antonella +8 more
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Effectiveness of XBB.1.5 vaccines and antiviral drugs against severe outcomes of omicron infection in the USA [PDF]
In the fall of 2023, the US Food and Drug Administration (FDA) authorised the use of the updated Moderna (Sept 11), Pfizer-BioNTech (Sept 11), and Novavax (Oct 3) COVID-19 vaccines containing a monovalent component of the XBB.1.5 variant “to provide ...
Duggal, Abhijit +4 more
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Temporal changes in SARS-CoV-2 clearance kinetics and the optimal design of antiviral pharmacodynamic studies: an individual patient data meta-analysis of a randomised, controlled, adaptive platform study (PLATCOV) [PDF]
Background Effective antiviral drugs prevent hospitalisation and death from COVID-19. Antiviral efficacy can be efficiently assessed in vivo by measuring rates of SARS-CoV-2 clearance estimated from serial viral genome densities quantitated in ...
Ashley, Elizabeth +25 more
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IPNA clinical practice recommendations on care of pediatric patients with pre-existing kidney disease during seasonal outbreak of COVID-19 [PDF]
The coronavirus disease 2019 (COVID-19) pandemic, instigated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has profoundly impacted healthcare infrastructures around the globe.
Admani B. +37 more
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Properties of Algerian Medicinal Thyme Compounds: Simulation using SwissADME and SuperPred Servers for the in Silico Study of Pharmacokinetic Parameters and Bioactivity. [PDF]
A large number of medicinal plants are used for the curative and preventive treatment of many diseases. In this article, we are interested in the study of the biological properties of Algerian medicinal thyme compounds using in-silico approaches.
CHEGHIB, Nedjoua +5 more
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Nirmatrelvir-ritonavir for COVID-19 [PDF]
Canadian Medical Association Journal, 2022 McDonald, Emily G, Lee, Todd C
openaire +2 more sources
Infection and Drug ResistanceNa Chen,1,2 Xuben Yu,3 Lu Li,1 Ping Yang,1 Rong Dong,1,4 Yizhen Huang,1,5 Xiao Ling,1,6 Qiaoqiao Shentu,1,7 Wenqiao Yu,8 Saiping Jiang1 1Department of Clinical Pharmaceutical, The First Affiliated Hospital of Zhejiang University School of Medicine ...
Chen N +9 more
doaj
In Silico Evaluation of Paxlovid’s Pharmacometrics for SARS-CoV-2: A Multiscale Approach [PDF]
, 2022 Bartha Ferenc Ágoston +4 more
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Efficient in vitro assay for evaluating drug efficacy and synergy against emerging SARS-CoV-2 strains [PDF]
Novel and repurposed antiviral drugs are available for the treatment of coronavirus disease 2019 (COVID-19). However, antiviral combinations may be more potent and lead to faster viral clearance, but the methods for screening antiviral combinations ...
Agyeman, Akosua Adom +13 more
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