Results 61 to 70 of about 8,661 (182)

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

Nature Communications, 2023
Therapeutic options against SARS-CoV-2 are underutilized. Two oral drugs, molnupiravir and paxlovid (nirmatrelvir/ritonavir), have received emergency use authorization.
Robert M. Cox, Carolin M. Lieber, Josef D. Wolf, Amirhossein Karimi, Nicole A. P. Lieberman, Zachary M. Sticher, Pavitra Roychoudhury, Meghan K. Andrews, Rebecca E. Krueger, Michael G. Natchus, George R. Painter, Alexander A. Kolykhalov, Alexander L. Greninger, Richard K. Plemper   +13 more
doaj   +1 more source

Exploring the structural and molecular interaction landscape of nirmatrelvir and Mpro complex: The study might assist in designing more potent antivirals targeting SARS-CoV-2 and other viruses

Journal of Infection and Public Health, 2023
Background: Several therapeutics have been developed and approved against SARS-CoV-2 occasionally; nirmatrelvir is one of them. The drug target of nirmatrelvir is Mpro, and therefore, it is necessary to comprehend the structural and molecular interaction
Chiranjib Chakraborty, Manojit Bhattacharya, Abdulrahman Alshammari, Metab Alharbi, Thamer H. Albekairi, Chunfu Zheng   +5 more
doaj   +1 more source

Frequency and Duration of the Clinical Symptoms of Patients With Mild COVID‐19: A Comparison With Influenza in the 2023–2024 Japanese Influenza Season, an Observational Study

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims This study aimed to compare the clinical symptoms of mild COVID‐19 and influenza during a period when both diseases circulated in the 2023–2024 influenza season in Japan. Methods Outpatients diagnosed with COVID‐19, influenza A, or influenza B by antigen test kits at 10 medical facilities in Japan were enrolled.
Takuma Bando, Hideyuki Ikematsu, Naoki Kawai, Tetsunari Maeda, Woon Joo Lee, Shinro Matsuura, Osame Tanaka, Takashi Kawashima, Hareaki Yamamoto, Ietaka Sato, Ken‐ichi Doniwa   +10 more
wiley   +1 more source

Cost-effectiveness of nirmatrelvir/ritonavir in COVID-19 patient groups at high risk for progression to severe COVID-19 in the Netherlands [PDF]

Background: Nirmatrelvir/ritonavir is indicated for the treatment of COVID-19 in symptomatic adults with increased risk for severe illness, not requiring supplemental oxygen yet.
Arteaga Duarte, Carlos H., de Goeij, Michelle H.M., Peters, Michel L., Postma, Maarten J., Spijkerman, Roy   +4 more
core   +1 more source

Reduced Mortality in COVID‐19 Patients Treated With Inhaled Extracellular Vesicles Expressing CD24

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Background: Severe COVID‐19, and other systemic infections, can trigger hyperinflammation leading to lung injury. EXO‐CD24, an inhaled extracellular vesicle therapy with anti‐inflammatory properties, has shown acute clinical benefit, but long‐term effects on survival remain unknown.
Shiran Shapira, Guy Vishnevsky, Hadas Yaakobi, Gil Shenberg, Mays Motlaq, Eliezer Liberman, Aminadav Kalisky, Gadi Benari, Sotirios Tsiodras, Nimrod Adi, Jan Lötvall, Nadir Arber   +11 more
wiley   +1 more source

Pharmacokinetics Profile and Genetics of Double Antiviral Therapy with Remdesivir and Nirmatrelvir/Ritonavir for Prolonged COVID-19 in Patients Treated with Rituximab: A Real-Life Study and Literature Review [PDF]

Introduction: Patients with hematologic malignancies are more likely to develop severe and prolonged SARS-CoV-2 infection, often showing viral persistence despite the use of authorized antivirals. Herein, we report the cases of four patients who received
Alice Palermiti, Antonio D’Avolio, Carlotta Giambra, Cecilia Grosso, Cristina Costa, Elisa Zanotto, Francesca Sidoti, Francesco Giuseppe De Rosa, Ilaria De Benedetto, Jessica Cusato, Luca Scaglione, Martina Billi, Matteo Ferrante, Sara Soloperto, Silvia Corcione, Simone Mornese Pinna, Tommaso Lupia   +16 more
core   +1 more source

Are Tetrapleura tetraptera Phytochemicals Druggable Against SARS‐CoV‐2 Papain‐Like Protein? A Computational Approach

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
SARS‐CoV2 Omicron and its substrains are still a critical global health issue and extremely contagious, even with widespread vaccination efforts. Hospitalizations and mortality rates linked to these variants are still prevalent. Current therapeutic options face challenges, including low effectiveness, suboptimal pharmacokinetics, and drug resistance ...
Frank Eric Tatsing Foka, Hazel Tumelo Mufhandu   +1 more
wiley   +1 more source

Nirmatrelvir: from discovery to modern and alternative synthetic approaches [PDF]

The global urgency in response to the COVID-19 pandemic has catalyzed extensive research into discovering efficacious antiviral compounds against SARS-CoV-2.
Alessandra Silvani, Andrea Citarella, Daniele Passarella, Francesco Migliano, Michela Galli, Valerio Fasano   +5 more
core   +1 more source

Discovery of Potent Quinazolinone Inhibitors Against SARS‐CoV‐2 Mpro via an Integrated Computational Strategy

ChemistrySelect, Volume 11, Issue 11, 18 March 2026.
ABSTRACT The main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 remains a primary target for antiviral drug discovery. In this study, an integrated computational workflow—comprising molecular docking, triplicate 200 ns molecular dynamics (MD) simulations, Molecular Mechanics–Generalized Born Surface Area (MM/GBSA) binding free ...
Renato Araújo da Costa, Alberto Soares Vanny, Arlan da Silva Gonçalves, Renilson Castro de Barros, Marinete Sardiha, João Augusto Pereira da Rocha, Elaine Cristina Medeiros da Rocha, Luciane do Socorro Nunes dos Santos Brasil, Davi do Socorro Barros Brasil   +8 more
wiley   +1 more source