Results 101 to 110 of about 187,675 (250)

Acute toxic leucoencephalopathy following protonitazene ingestion

British Journal of Clinical Pharmacology, EarlyView.
Background Distribution of illicit counterfeit alprazolam containing the highly potent synthetic opioid‐receptor agonist protonitazene recently resulted in a number of severe overdoses in Ireland. We report three cases that presented to our hospital, within 6 weeks of one another, following ingestion of illicitly‐sourced alprazolam.
Ruadhan O'Laoi, Holly Acton, Pierce Kavanagh, Isabelle Hunt, Niall Sheehy, Cormac Kennedy   +5 more
wiley   +1 more source

In the center of this image is a sample of red and gray sandstone from Marquette, Michigan, part of the NIST stone wall

, 2017
The NIST stone wall was built using 2,352 stones from 47 US states and 320 from 16 foreign countries. The wall is approximately 12 m long, 4 m high, 0.6 m thick at the bottom, and 0.3 m at the top. The aim of the wall construction was to study the aging
National Institute of Standards and Technology and Technology
core  

Unmasking Glycoforms: Lectin‐Based Profiling and Functional Implications of Targeted Glycosylation Knockouts in Chinese Hamster Ovary Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Monoclonal antibody (mAb) glycosylation is a critical quality attribute that is difficult to rationally engineer and rapidly assess during cell line development. Here, we investigate whether cell‐surface glycosylation can serve as a surrogate readout of mAb product glycosylation following targeted glycogene engineering in CHO cells.
Cristina Abascal Ruiz, Sheryl Li Yan Lim, Jacobus Brink, Sara Carillo, Eoin Casey, Jonathan Bones, Ioscani Jiménez del Val   +6 more
wiley   +1 more source

Stone samples from New Jersey embedded in the NIST stone wall

, 2017
The NIST stone wall was built using 2,352 stones from 47 US states and 320 from 16 foreign countries. The wall is approximately 12 m long, 4 m high, 0.6 m thick at the bottom, and 0.3 m at the top. The aim of the wall construction was to study the aging
National Institute of Standards and Technology and Technology
core  

GlycoMAC: A Multiscale Metabolic‐Glycosylation Framework for Predicting Glycosylation Across Conditions in Mammalian Cell Cultures

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Antibody productivity and glycosylation quality in CHO cell cultures emerge from a dynamically evolving metabolic environment, yet existing models often work in isolation or at a single scale. Here, we present a multiscale mechanistic framework linking molecular, cellular, and macroscopic scales to predict how inputs shape bioprocess ...
Yuming Zeng, Sarah W. Harcum, Jinxiang Pei, Wei Xie   +3 more
wiley   +1 more source

Serotype‐Tailored Midstream and Downstream Operations to Advance the Manufacturing of Adeno‐Associated Viral Vectors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated viruses (AAVs) are the leading vectors for in vivo gene therapy, fueling a growing demand for scalable and robust biomanufacturing processes. Yet, the impact of cell lysis conditions on the performance of midstream and downstream unit operations across serotypes remains poorly characterized.
Arianna Minzoni, Shriarjun Shastry, Eduardo Barbieri, Morgan R. Hurst, Kelvin Idanwekhai, Yuxuan Wu, Katherine Ernst, Wai‐Keen Chung, Christopher Bombeck, Saad A. Khan, Sushmita Koley, Gabriella Kiss, Oliver Rammo, Alexander Tropsha, Cristiana Boi, Michael A. Daniele, Steven Cramer, Barry Byrne, Stephen Kaminsky, Angie Snell Bennett, Stefano Menegatti   +20 more
wiley   +1 more source

Author Correction: Super-resolved time–frequency measurements of coupled phonon dynamics in a 2D quantum material

Scientific Reports, 2023
Christian Gentry, Chen-Ting Liao, Wenjing You, Sinéad A. Ryan, Baldwin Akin Varner, Xun Shi, Meng-Xue Guan, Thomas Gray, Doyle Temple, Sheng Meng, Markus Raschke, Kai Rossnagel, Henry C. Kapteyn, Margaret M. Murnane, Emma Cating-Subramanian   +14 more
doaj   +1 more source

In the center of this image is a sample of coarse limestone from New Bern, North Carolina, part of the NIST stone wall

, 2017
The NIST stone wall was built using 2,352 stones from 47 US states and 320 from 16 foreign countries. The wall is approximately 12 m long, 4 m high, 0.6 m thick at the bottom, and 0.3 m at the top. The aim of the wall construction was to study the aging
National Institute of Standards and Technology and Technology
core  

Regenerative perfusion bioreactor for biologics production with lower COGs

Biotechnology Progress, EarlyView.
Abstract Perfusion bioreactor systems enable intensified bioprocessing with high cell densities and volumetric productivities in monoclonal antibody (mAb) manufacturing. However, their widespread adoption remains constrained by the high consumption of chemically defined cell culture media.
Eric Wynne, Dohyun Park, Hourieh Ahi, Jaeweon Lee, Seongkyu Yoon, Jongyoon Han   +5 more
wiley   +1 more source

Recommended nomenclature convention for the NISTCHO cell line and its product monoclonal antibody, cNISTmAb

mAbs
NISTCHO is a Chinese hamster ovary (CHO) cell line expressing the same amino acid sequences as the heavy and light chains of the National Institute of Standards and Technology (NIST) monoclonal antibody [Reference Material (RM) 8671 NISTmAb]. NISTCHO was
Megan H. Cleveland, Ioannis L. Karageorgos, John P. Marino, Michael J. Tarlov, Katharina S. Yandrofski, Rebecca A. Zangmeister, Zvi Kelman   +6 more
doaj   +1 more source