Results 51 to 60 of about 432,709 (333)

ANSID: a Solid-Phase Proteomic Approach for Identification and Relative Quantification of Aromatic Nitration Sites

Frontiers in Chemistry, 2016
Nitration of tyrosine and other aromatic amino acid residues in proteins occurs in the setting of inflammatory, neurodegenerative and cardiovascular diseases – importantly, this modification has been implicated in the pathogenesis of diverse diseases and
Tal eNuriel, Tal eNuriel, Julia eWhitehouse, Yuliang eMa, Emily eMercer, Emily eMercer, Neil eBrown, Steven S Gross   +7 more
doaj   +1 more source

The alkaline transition of cytochrome c revisited: Effects of electrostatic interactions and tyrosine nitration on the reaction dynamics [PDF]

, 2019
Here we investigated the effect of electrostatic interactions and of protein tyrosine nitration of mammalian cytochrome c on the dynamics of the so-called alkaline transition, a pH- and redox-triggered conformational change that implies replacement of ...
Castro, Maria Ana, Murgida, Daniel Horacio, Oviedo Rouco, Santiago, Radi, Rafael, Spedalieri, Ana Cecilia, Tomasina, Florencia, Tortora, Verónica, Álvarez Paggi, Damián Jorge   +7 more
core   +1 more source

Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells

Journal of Experimental Medicine, 2011
Blocking CCL2 nitration in tumors promoted CD8+ influx and reduced tumor growth and prolonged survival in mice when combined with adoptive cell therapy.
B. Molon, S. Ugel, Federica Del Pozzo, C. Soldani, S. Zilio, D. Avella, A. de Palma, P. Mauri, A. Monegal, M. Rescigno, B. Savino, P. Colombo, N. Jonjić, S. Pečanić, L. Lazzarato, R. Fruttero, A. Gasco, V. Bronte, A. Viola   +18 more
semanticscholar   +1 more source

Temporal Trends and Short‐ and Long‐Term Mortality of People With Acute Myocardial Infarction and Rheumatoid Arthritis: A Nationwide Cohort Study

Arthritis Care &Research, EarlyView.
Objective We investigated whether a diagnosis of rheumatoid arthritis (RA) affects the quality of inpatient acute myocardial infarction (AMI) care and long‐term mortality post‐AMI. Methods We analyzed data from 784,091 adults, 6,047 with a diagnosis of RA, from England and Wales hospitalized with AMI between 2005 and 2019 from the Myocardial Ischaemia ...
Megan Butler, Nicholas Weight, Muhammad Rashid, Rodrigo Bagur, Purvi Parwani, Samantha Hider, Edward Roddy, Robert Butler, Mamas A. Mamas   +8 more
wiley   +1 more source

The specificity of endogenous fatty acid nitration: only conjugated substrates support the in vivo formation of nitro-fatty acids

Redox Biochemistry and Chemistry
Through multiple pathways, nitrogen dioxide (•NO2) is the main species involved in endogenous nitration reactions. Early studies in the field primarily explored tyrosine nitration, a dominant reaction in the field. It was later shown that lipids are also
Nicole Colussi, Fei Chang, Francisco J. Schopfer   +2 more
doaj   +1 more source

High Glucose-Mediated Tyrosine Nitration of PI3-Kinase: A Molecular Switch of Survival and Apoptosis in Endothelial Cells

Antioxidants, 2018
Diabetes and hyperglycemia are associated with increased retinal oxidative and nitrative stress and vascular cell death. Paradoxically, high glucose stimulates expression of survival and angiogenic growth factors.
Sally L. Elshaer, Tahira Lemtalsi, Azza B. El-Remessy   +2 more
doaj   +1 more source

Glucocorticoids for human skin: New aspects of the mechanism of action [PDF]

, 2005
Topical glucocorticoids have always been considered first-line drugs for inflammatory diseases of the skin and bronchial system. Applied systemically, glucocorticoids are used for severe inflammatory and immunological diseases and the inhibition of ...
Ahmed, M., Holtje, H. D., Kleuser, B., Korting, Hans Christian, Schäfer-Korting, Monika   +4 more
core   +1 more source

Exploring Dipolar Dynamics and Ionic Transport in Metal‐Organic Frameworks: Experimental and Theoretical Insights

Advanced Functional Materials, EarlyView.
In this study, the interplay of dipolar dynamics and ionic charge transport in MOF compounds is investigated. Synthesizing the novel structure CFA‐25 with integrated freely rotating dipolar groups, local and macroscopic effects, including interactions with Cs cations are explored.
Ralph Freund, Arthur Schulz, Peter Lunkenheimer, Maryana Kraft, Thomas Bergler, Harald Oberhofer, Dirk Volkmer   +6 more
wiley   +1 more source

A π-Extended Donor-Acceptor-Donor Triphenylene Twin linked via a Pyrazine-bridge [PDF]

, 2015
Beta-amino triphenylenes can be accessed via palladium catalyzed amination of the corresponding triflate using benzophe-none imine. Transformation of amine 6 to benzoyl amide 18 is also straightforward and its wide mesophase range demon-strates that the ...
Andrew N. Cammidge, Boden N., Boden N., Bunk O., Bushby R. J., Cammidge A. N., Cammidge A. N., Cammidge A. N., Crank G., Destrade C., Dutta T., Foster E. J., Foster E. J., Frisch M. J., Iino H., Ito S., Kawata K., Kong X., Kong X., Kumar S., Kumar S., Laschat S., Lavigueur C., Lu X., Min Xu, Mori H., Pisula W., Rebecca J. Turner, Sergeyev S., Shklyarevskiy I. O., Sonia Remiro-Buenamañana, Surry D. S., Tracz A., Tsutumo I.-I., Tsutumo I.-I., Weikang Xiao, Wolfe J. P., Xiao W., Xiao Yang, Xiping Jing, Yeh M.-C., Zhang L., Zhang L., Zhiqun He   +43 more
core   +1 more source

Uric acid enhances longevity and endurance and protects the brain against ischemia [PDF]

, 2020
Among mammals, there is a positive correlation between serum uric acid (UA) levels and life span. Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived mammals.
Argüelles Castilla, Sandro, Camandola, Simonetta, Cutler, Roy G., Feldman, Neil H., Haran, James B., Mattsona, Mark P., Seon Yoon, Jeong   +6 more
core   +1 more source