Results 161 to 170 of about 646,019 (403)

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

open access: yesAdvanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang   +7 more
wiley   +1 more source

Reinstating Niche Failure in Diabetic Cranial Defects via Chronotaxic Signal‐Amplifying Fluidic Biomimetic Hydrogel

open access: yesAdvanced Science, EarlyView.
An in situ moldable GelSSO/PDA@SDF hydrogel functions as a chronotaxic signal‐amplifying biomimetic niche to restore regenerative failure in diabetic cranial defects. By sequentially releasing SDF‐1α‐loaded PDA nanoparticles and osteoinductive oligodeoxynucleotides, it orchestrates immunomodulation, progenitor recruitment, angiogenesis, and ...
Yingji Mao   +5 more
wiley   +1 more source

Thermodynamics of Oxidation-Reduction Reactions in Mammalian Nitric-oxide Synthase Isoforms [PDF]

open access: hybrid, 2004
Ying Gao   +9 more
openalex   +1 more source

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

open access: yesAdvanced Science, EarlyView.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan   +5 more
wiley   +1 more source

The non-obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine [PDF]

open access: yes, 2008
The concept of Endothelium Derived Relaxing Factor (EDRF), put forward by Furchgott in the earlier 80s of the past century, implies that nitric oxide (NO) produced by NO synthase (NOS) in the endothelium in response to acetylcholine (ACh) passively ...
Frantisek Kristek   +5 more
core   +1 more source

The Oncogenic Properties Of The Redox Inflammatory Protein Inducible Nitric Oxide Synthase In ER(-) Breast Cancer

open access: gold, 2015
David A. Wink   +5 more
openalex   +1 more source

Violent suicidal behaviour in bipolar disorder is associated with nitric oxide synthase 3 gene polymorphism [PDF]

open access: bronze, 2015
J. Oliveira   +15 more
openalex   +1 more source

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