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Expression of Concern: Gutsaeva et al., "Transient Hypoxia Stimulates Mitochondrial Biogenesis in Brain Subcortex by a Neuronal Nitric Oxide Synthase-Dependent Mechanism". [PDF]
J Neuroscieuropepmc +1 more source
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Nitric oxide is fundamental to neurovascular coupling in humans
Journal of Physiology, 2020Preclinical models have demonstrated that nitric oxide is a key component of neurovascular coupling; this has yet to be translated to humans. We conducted two separate protocols utilizing intravenous infusion of a nitric oxide synthase inhibitor and ...
R. Hoiland +10 more
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Immunobiology of Nitric Oxide and Regulation of Inducible Nitric Oxide Synthase.
Results and problems in cell differentiation, 2017Nitric oxide (NO) is a bioactive gas that has multiple roles in innate and adaptive immune responses. In macrophages, nitric oxide is produced by inducible nitric oxide synthase upon microbial and cytokine stimulation. It is needed for host defense against pathogens and for immune regulation.
Martin Lee +4 more
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Regulation of nitric oxide synthase by nitric oxide.
Molecular Pharmacology, 1993Nitric oxide (NO) is a recently discovered messenger for the activation of soluble guanylate cyclase in a wide variety of cell types. Although enzymes involved in NO synthesis have been discovered, the regulation of their action is not clear. The possibility of NO regulating the activity of a crude NO synthase (EC 1.14.23) preparation from bovine ...
A, Rengasamy, R A, Johns
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Biochemical Society Transactions, 1996
Nitric oxide (NO) is a biologically active product enzymatically formed from a terminal guanidino-nitrogen of L-arginine by members of the NO synthase (NOS) gene family. Members of NO synthases are classified into three isoforms NOS 1, 2, and 3. This original classification of NOS was based on the physical and biochemical characteristics of the ...
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Nitric oxide (NO) is a biologically active product enzymatically formed from a terminal guanidino-nitrogen of L-arginine by members of the NO synthase (NOS) gene family. Members of NO synthases are classified into three isoforms NOS 1, 2, and 3. This original classification of NOS was based on the physical and biochemical characteristics of the ...
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, 2006 The discovery of the L–arginine:NO pathway has proven to be one of the most important and exciting scientific developments of the last decade. This pathway is involved in a myriad of physiologic roles that range from the control of vascular tone and blood pressure to the modulation of skeletal muscle function.
Bismark Amoah-Apraku, Nicolas J. Guzman
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Detection of nitric oxide and nitric oxide synthases in psoriasis
Archives of Dermatological Research, 1998Biopsies from psoriasis lesions and clinically uninvolved skin of eight patients and five normal subjects were studied by immunocytochemistry with computerized image analysis for the presence of endothelial, neuronal and inducible isoforms of nitric oxide synthase.
P Grabowksi +6 more
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Multimodality imaging of nitric oxide and nitric oxide synthases
Free Radical Biology and Medicine, 2009Nitric oxide (NO) and NO synthases (NOSs) are crucial factors in many pathophysiological processes such as inflammation, vascular/neurological function, and many types of cancer. Noninvasive imaging of NO or NOS can provide new insights in understanding these diseases and facilitate the development of novel therapeutic strategies.
Weibo Cai, Hao Hong, Jiangtao Sun
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Nitric oxide and nitric oxide synthase activity in plants
Phytochemistry, 2004Research on NO in plants has gained considerable attention in recent years mainly due to its function in plant growth and development and as a key signalling molecule in different intracellular processes in plants. The NO emission from plants is known since the 1970s, and now there is abundant information on the multiple effects of exogenously applied ...
F. Javier Corpas +2 more
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