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Nitric oxide and nitric oxide synthase activity in plants
Phytochemistry, 2004Research on NO in plants has gained considerable attention in recent years mainly due to its function in plant growth and development and as a key signalling molecule in different intracellular processes in plants. The NO emission from plants is known since the 1970s, and now there is abundant information on the multiple effects of exogenously applied ...
F. Javier Corpas +2 more
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Catalysis by nitric oxide synthase
Current Opinion in Chemical Biology, 1998The enzyme nitric oxide synthase catalyzes the oxidation of the amino acid L-arginine to L-citrulline and nitric oxide in an NADPH-dependent reaction. Nitric oxide plays a critical role in signal transduction pathways in the cardiovascular and nervous systems and is a key component of the cytostatic/cytotoxic function of the immune system ...
Michael A. Marletta +2 more
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Nitric oxide synthase in invertebrates
The Histochemical Journal, 1995The gas nitric oxide is now recognized as an important signalling molecule that is synthesized from L-arginine by the enzyme nitric oxide synthase. This enzyme can be localized by different methods, including immunocytochemistry and the histochemical reaction for NADPH diaphorase.
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Nitric oxide synthases and osteoarthritis
Current Rheumatology Reports, 2007The production of nitric oxide (NO) by chondrocytes is increased in human osteoarthritis. The excessive production of NO inhibits matrix synthesis and promotes its degradation. Furthermore, by reacting with oxidants such as superoxide anion, NO promotes cellular injury and renders the chondrocyte susceptible to cytokine-induced apoptosis.
Jose U. Scher +2 more
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Nitric oxide synthase and hypertension
Current Opinion in Nephrology and Hypertension, 2002Nitric oxide, the metabolic product of L-arginine by the enzyme nitric oxide synthase, plays a pivotal role in the regulation of vascular homeostasis. Its complex interaction with the autocrine and paracrine systems, particularly angiotensin II, modulates vasoconstriction and vasodilatation as well as the architectural remodeling of the vascular bed ...
Baudouin Leclercq +2 more
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Bacterial Nitric Oxide Synthases
Annual Review of Biochemistry, 2010Nitric oxide synthases (NOSs) are multidomain metalloproteins first identified in mammals as being responsible for the synthesis of the wide-spread signaling and protective agent nitric oxide (NO). Over the past 10 years, prokaryotic proteins that are homologous to animal NOSs have been identified and characterized, both in terms of enzymology and ...
Bhumit A. Patel +2 more
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Mitochondrial nitric oxide synthase
Trends in Pharmacological Sciences, 2005Mitochondria produce nitric oxide (NO) through a Ca(2+)-sensitive mitochondrial NO synthase (mtNOS). The NO produced by mtNOS regulates mitochondrial oxygen consumption and transmembrane potential via a reversible reaction with cytochrome c oxidase.
Pedram Ghafourifar, Enrique Cadenas
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Endothelial Nitric Oxide Synthase
2011Diabetic nephropathy remains a leading cause for end-stage renal disease indicating a failure of current therapeutic strategies. One factor that impairs our ability to make advances has been the inadequacy of most animal models in manifesting advanced diabetic renal disease.
Takahiko Nakagawa, Richard J. Johnson
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Nitric Oxide Synthase Inhibitors [PDF]
, 2003 In 1990, several studies reported that an enhanced formation of endogenous nitric oxide (NO) contributes to the hypotension caused by endotoxin and tumor-necrosis factor-α (TNFα) (1-3). In addition, it became apparent that this overproduction of NO also plays an important role in the pathophysiology of the vascular hyporesponsiveness to vasoconstrictor
Dilani Siriwardena +2 more
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Chemical Research in Toxicology, 1998
Inhibitory action of a variety of quinoid compounds on neuronal nitric oxide synthase (nNOS) activity was examined with a 20000g rat cerebellar supernatant preparation and purified nNOS. The inhibition of citrulline formation from l-arginine by quinones, which exhibit one-electron reduction potentials (E17) ranging between -240 and -100 mV, increased ...
Shino Homma-Takeda +4 more
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Inhibitory action of a variety of quinoid compounds on neuronal nitric oxide synthase (nNOS) activity was examined with a 20000g rat cerebellar supernatant preparation and purified nNOS. The inhibition of citrulline formation from l-arginine by quinones, which exhibit one-electron reduction potentials (E17) ranging between -240 and -100 mV, increased ...
Shino Homma-Takeda +4 more
openaire +3 more sources