Results 351 to 360 of about 630,432 (401)

Inhibition of Nitric Oxide Formation by Neuronal Nitric Oxide Synthase by Quinones:  Nitric Oxide Synthase as a Quinone Reductase

Chemical Research in Toxicology, 1998
Inhibitory action of a variety of quinoid compounds on neuronal nitric oxide synthase (nNOS) activity was examined with a 20000g rat cerebellar supernatant preparation and purified nNOS. The inhibition of citrulline formation from l-arginine by quinones, which exhibit one-electron reduction potentials (E17) ranging between -240 and -100 mV, increased ...
Shino Homma-Takeda, Yoshito Kumagai, Nobuhiro Shimojo, Kazumi Midorikawa, Hiromi Nakajima   +4 more
openaire   +3 more sources

Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase.

Science, 1994
The proposal that nitric oxide (NO) or its reactant products mediate toxicity in brain remains controversial in part because of the use of nonselective agents that block NO formation in neuronal, glial, and vascular compartments. In mutant mice deficient
Zhihong Huang, Paul L Huang, N. Panahian, T. Dalkara, M. Fishman, M. Moskowitz   +5 more
semanticscholar   +1 more source

Mitochondrial nitric oxide synthase

Frontiers in Bioscience, 2007
Nitric oxide (NO) regulates several cellular functions via reversible regulation of mitochondrial respiration. Nitric oxide also reacts with mitochondrial superoxide anion to produce the potent oxidative species peroxynitrite that irreversibly hinders mitochondrial activities. Recent findings demonstrating that mitochondria produce NO via mitochondrial
Pedram, Ghafourifar, Chandan K, Sen
openaire   +2 more sources

Nitric Oxide Synthase Assays

Current Protocols in Pharmacology, 1998
AbstractNitric oxide (NO) is a widespread messenger molecule that regulates cardiovascular tone, immune responses, and neuronal function. This unit provides a simple protocol for measuring NO production based on the stoichiometric formation of the byproduct L‐citrulline by nitric oxide synthase (NOS) when NO is produced.
openaire   +3 more sources

Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes

Journal of Neuroscience Research, 1997
It has been previously demonstrated that microglia and astrocytes produce micromolar amounts of nitric oxide in vitro. In this study, we demonstrate that primary rat oligodendrocytes can be stimulated to produce iNOS mRNA as detected by Northern blot and in situ hybridization analysis and a 131-kDa iNOS protein by Western blot analysis; protein was ...
Jean E. Merrill, Allan MacKenzie-Graham, Minzhen Ding, Sean Murphy, Branislava Mitrovic, Joel C. Dopp, Louis J. Ignarro, Charles J. Lowenstein, Jeannette Griscavage   +8 more
openaire   +3 more sources

Nitric Oxide and Nitric Oxide Synthase Inhibitors in Sepsis

Digestive Surgery, 1996
Nitric oxide (NO) is a simple but biologically highly active gas. It has multiple roles in normal physiology, e.g. as a potent vasodilator, immunomodulator and neurotransmitter.
Hans Ulrich Rothen, Daniel Schölly
openaire   +2 more sources

Nitric oxide, nitric oxide synthase, and hypertensive vascular disease

Current Hypertension Reports, 1999
In normotension the endothelium produces mainly nitric oxide (NO) and prostacyclin, and the vasodilator and growth inhibitory influence predominates. Hypertension, however, is associated with a shift towards enhanced constriction and vascular hypertrophy.
Rudi Busse, Ingrid Fleming
openaire   +3 more sources

Nitric oxide and macrophage function.

Annual Review of Immunology, 1997
At the interface between the innate and adaptive immune systems lies the high-output isoform of nitric oxide synthase (NOS2 or iNOS). This remarkable molecular machine requires at least 17 binding reactions to assemble a functional dimer.
J. MacMicking, Q. Xie, C. Nathan
semanticscholar   +1 more source

Nitric Oxide Synthase Expression and Nitric Oxide Toxicity in Oligodendrocytes

Antioxidants & Redox Signaling, 2006
Oligodendrocytes (OLG) have more complex interactions with nitric oxide (NO) than initially suspected. Historically, OLG were seen only as targets of high NO levels released from other cells. Expression of nitric oxide synthase type II (NOS-2) in primary cultures of OLGs stimulated by cytokines led to controversy due to the presence of small numbers of
Joyce A. Benjamins, Anne I. Boullerne
openaire   +3 more sources

mRNA Expressions of Inducible Nitric Oxide Synthase, Endothelial Nitric Oxide Synthase, and Neuronal Nitric Oxide Synthase Genes in Meningitis Patients

Genetic Testing and Molecular Biomarkers, 2011
Meningitis is an inflammation of the protective membranes covering the brain and spinal cord caused by bacteria, fungi, or viruses with various clinical symptoms. Although meningitis is not so prevalent, it remains the most serious contagious disease. The aim of our study was to investigate the effect of gene expressions of nitric oxide synthases (NOS)
Ahmet Arslan, Mehmet Yavuz Coskun, Bulent Gogebakan, Yusuf Ziya Igci, Ecir Ali Çakmak, Ercan Sivasli, Mehri Igci, Seniz Demiryürek, Mustafa Namiduru, Beyhan Cengiz, Serdar Oztuzcu, Esma Ozkara   +11 more
openaire   +3 more sources