Results 101 to 110 of about 58,072 (277)

TWEAK/Fn14 Signaling Drives Oxidative Cardiac Injury in Systemic Lupus Erythematosus: Evidence From Patient Biomarker Studies, Lupus Mouse Models, and Cardiomyocyte Assays

Arthritis &Rheumatology, EarlyView.
Objective Cardiac involvement is a major cause of morbidity in systemic lupus erythematosus (SLE). Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) is elevated in SLE, but its contribution to lupus‐associated cardiac injury is unclear. We investigated the role of TWEAK/fibroblast growth factor–inducible 14 (Fn14) signaling in SLE‐related ...
Yale Liu, Zhu Yan, Xueting Peng, Meixuan Li, Juan Wang, Yan Zhang, Xiaoqian Hu, Mingzhu Zhou, Kaixuan Ren, Dan Zhang, Xingyi Guo, Yumin Xia, Huanhuan Huo   +12 more
wiley   +1 more source

Role of chemerin, a novel adipochemokine, in the human microvascular endothelial cell (HMEC)-1 line [PDF]

Chemerin is a newly identified adipokine and exerts its functional effects by binding to its natural GPCR, known as CMKLR1. Chemerin is highly expressed in the adipose tissue and in lower levels in other body tissues; and is known to play an important
Kaur, Jaspreet
core  

ANK1 and EPB41 Variants and the Risk of Steroid‐Induced Osteonecrosis

Arthritis &Rheumatology, EarlyView.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Characterisation of the anti-inflammatory and anti-proliferative effects of natriuretic peptides in rodents.

, 2007
Natriuretic peptides are a family of vasoactive hormones that play important roles in cardiovascular homeostasis. These peptides exert biological effects primarily via activation of guanylate cyclase (GC)-coupled natriuretic peptide receptors (NPR) that ...
Panayiotou, C.M.
core  

Análise dos mecanismos envolvidos no relaxamento induzido pelo sesquiterpeno poligodial em vasos de coelho e cobaia e no corpo cavernoso de coelho in vitro [PDF]

, 2000
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas.Este estudo investigou os mecanismos de ação envolvidos no relaxamento produzido pelo sesquiterpeno poligodial (0,00427 - 42,74 mM) , isolado da planta Drymis
André, Eunice
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Identification of an endothelial-like type III NO synthase in LLC-PK1 kidney epithelial cells

, 1994
Porcine kidney tubular epithelial cells (LLC-PK1) produce nitric oxide or a related compound (e.g., a nitrosothiol) after stimulation with various agonists. We now report the identification and characterization of a constitutive, particulate nitric oxide
W. R. Tracey, F. Murad, M. Nakane, J. S. Pollock, U. Forstermann   +4 more
core   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Fisiopatologia de la cèl·lula endotelial en la cirrosi hepàtica [PDF]

, 2008
[cat] La cirrosi hepàtica constitueix un estadi de fibrosi hepàtica irreversible que es produeix com a resposta a un dany hepàtic prolongat i que té com a conseqüència l'acumulació de teixit connectiu al fetge degut a un desequilibri important entre la ...
Tugues Solsona, Sònia
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Nitric oxide release and contractile properties of skeletal muscles from mice deficient in type III NOS

, 2000
Skeletal muscle constitutively expresses both the type I (neuronal) and type III (endothelial) isoforms of nitric oxide synthase (NOS). We tested the functional importance of type III NOS using skeletal muscles with similar levels of type III NOS ...
Robert M. Bryan, Wulf Hirschfield, Melanie R. Moody, Michael B. Reid, William E. O'Brien, Anthony R. Gregg   +5 more
core   +1 more source

Lowering salivary pH with sugar‐containing gum augments salivary nitrite production and blood pressure reduction with dietary nitrate (beetroot juice)

British Journal of Clinical Pharmacology, EarlyView.
Acutely lowering salivary pH (with sugar‐containing acidic gum vs. sugar‐free gum) augments salivary nitrate reduction to nitrite, plasma nitrite concentration, and blood pressure lowering with dietary nitrate. Modifying salivary pH reveals a mechanism by which the nitrate‐nitrite‐NO pathway may be upregulated/inhibited, with potential for other ...
Andrew J. Webb, Harriet Clift, Callum Hill, Nur Mousa, Navanithan Arun Jayaraj, Jasmine Quraishi, Charlotte E. Mills, Kevin O'Gallagher   +7 more
wiley   +1 more source