Results 171 to 180 of about 127,382 (281)

Multitarget mechanisms of the herb pair <i>Achyranthes bidentata</i> and <i>Paeonia lactiflora</i> Pall. in ameliorating hypertensive cardiomyopathy: combining network pharmacology and functional exploration. [PDF]

Front Pharmacol
Zhang Y, Wang Y, Liu J, Zhao Y, He Y, Yan P, Ren S, Lyu Y, Jia W, Sun Y, Lin S, Lin Y.   +11 more
europepmc   +1 more source

Ginsenoside Rb1 alleviates endothelial dysfunction and vascular remodeling in preeclampsia via activation of the PI3K-Akt-eNOS pathway. [PDF]

Sci Rep
Jia W, Wang W, Zhang B, Wang C, Huang X.
europepmc   +1 more source

JAK inhibitors in livedoid vasculopathy associated with thrombophilia and refractory to anticoagulation: report and literature review. [PDF]

An Bras Dermatol
Criado GJ, Criado PR, Lorenzini D, Miot HA.   +3 more
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Probiotics in atherosclerosis: mechanisms, efficacy and future directions - a review study. [PDF]

Front Immunol
Cai Y.
europepmc   +1 more source

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

ADAMTS13 ameliorates diabetic nephropathy by Nrf2/GPX4/eNOS signaling pathway. [PDF]

Ren Fail
Wang H, Guo J, Wang Q, Cai F, Jiang S, Fei L, Zhang G, Yu G, Li B, Zhou J, Li Z, Han F, Lai EY, Zhou S.   +13 more
europepmc   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Maternal Gestational Diabetes Impairs Fetoplacental Insulin-Induced Vasodilation via AKT/eNOS Pathway and Reduces Placental Efficiency. [PDF]

Int J Mol Sci
Hengst CM, Villar-Ballesteros ML, Brendel H, Giebe S, Brunssen C, Frühauf A, Birdir C, Taylor PD, Poston L, Morawietz H.   +9 more
europepmc   +1 more source