Results 191 to 200 of about 57,731 (238)

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Endothelial-to-Mesenchymal Transition Mechanisms in Vascular Remodeling of Pulmonary Hypertension. [PDF]

Int J Mol Sci
Chen X, Su J, Liu H, Qin Y, Li M, Xie P.
europepmc   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

JAK inhibitors in livedoid vasculopathy associated with thrombophilia and refractory to anticoagulation: report and literature review. [PDF]

An Bras Dermatol
Criado GJ, Criado PR, Lorenzini D, Miot HA.   +3 more
europepmc   +1 more source

Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib, Francisco Emilio Fierro, Maria Ortega Abad, Ricardo Correa   +3 more
wiley   +1 more source

Clinicopathological and molecular characterization of tumor-associated macrophages in sporadic and Xeroderma Pigmentosum-related cutaneous melanoma. [PDF]

BMC Cancer
Chikhaoui A, Tounsi H, Nabouli I, Jones M, Jenni R, Ahmed MB, Naouali C, Zghal M, Turki H, Yacoub-Youssef H.   +9 more
europepmc   +1 more source

Endothelial mitochondrial homeostasis in the development and progression of atherosclerosis. [PDF]

Front Cardiovasc Med
Remex NS, Miah MS, Islam T, Aishwarya R, Sinha MH, Dhar P, Dhaou CB, Orr AW, Bhuiyan MS.   +8 more
europepmc   +1 more source

Cardiovascular Benefits of <i>Salvia miltiorrhiza</i> (Danshen) Supplementation: Bioactive Constituents, Mechanisms, Clinical Evidence and Implications for Nutritional Care. [PDF]

Food Sci Nutr
Vikal A, Maurya R, Patel P, Kurmi BD, Setzer WN, Sharifi-Rad J, Calina D.   +6 more
europepmc   +1 more source

Mandelamide Isolated from <i>Prunus persica</i> Flowers Attenuates TNF-α-Driven Oxidative and Inflammatory Responses in Human Skin Cells. [PDF]

Biomolecules
Choi YJ, Ann HW, Son SR, Jang DS, Lee S.
europepmc   +1 more source

The Role of Hydrogen Sulfide in the Pathophysiology and Therapeutic Modulation of Hypertension: A Scoping Review. [PDF]

Cureus
Nikolov NN, Yambolov SN, Grigorov RK, Yankov YG.   +3 more
europepmc   +1 more source