Results 201 to 210 of about 57,731 (238)

Role of Sp1 in Transcriptional Activation of Human Nitric Oxide Synthase Type III Gene

Biochemical and Biophysical Research Communications, 1995
Endothelial nitric oxide synthase (eNOS or NOS-III) is constitutively expressed. To elucidate the mechanism by which the basal expression of NOS-III gene is activated, we constructed in a luciferase vector, pXP1, serial 5'-deletion mutants of a 1.3-kb 5'-flanking fragment and transiently expressed them in cultured human endothelial cells.
J L, Tang, A, Zembowicz, X M, Xu, K K, Wu   +3 more
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Nitric oxide synthase type I and type III gene expression are developmentally regulated in rat lung

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1994
The successful transition from fetal to neonatal life involves a marked decline in pulmonary vascular resistance which is modulated in part by endothelium-derived nitric oxide. To define the molecular processes which prepare the pulmonary circulation for nitric oxide mediation of vasodilatation at the time of birth, we determined the ontogeny of ...
A J, North, R A, Star, T S, Brannon, K, Ujiie, L B, Wells, C J, Lowenstein, S H, Snyder, P W, Shaul   +7 more
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Direct Effect of Temperature on the Catalytic Activity of Nitric Oxide Synthases Types I, II, and III

Nitric Oxide, 1999
The effect of temperature (between 5.0 and 45.0 degrees C) on the catalytic activity of nitric oxide synthases types I, II, and III (NOS-I, NOS-II, and NOS-III, respectively) has been investigated, at pH 7.5. The value of V(max) for NOS-I activity increases from 1.8 x 10(1) pmol min(-1) mg(-1), at 5.0 degrees C, to 1.8 x 10(2) pmol min(-1) mg(-1), at ...
VENTURINI G, COLASANTI, Marco, FIORAVANTI E, BIANCHINI A, ASCENZI P.   +4 more
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Regulation and Dysregulation of Constitutive Nitric Oxide Synthases Types I and III

1995
Mammalian cells synthesize nitric oxide (NO) from l-arginine by NO synthases (NOS), members of the cytochrome P450 gene family. NO represents the best understood member of a novel class of redox-active transmembrane and intracellular signaling molecules that may also include CO and oxygen radicals.
H H, Schmidt, H, Hofmann, P, Ogilvie
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Expression of endothelial (Type III) nitric oxide synthase in cytotrophoblastic cell lines: Regulation by hypoxia and inflammatory cytokines

Placenta, 1998
Expression of endothelial nitric oxide synthase (eNOS) has been localized to the villous syncytiotrophoblasts suggesting that NO release from these cells could prevent platelet adhesion and aggregation in the intervillous space. Hypoxia- or inflammation-dependent changes in the release of this vasoactive substance may result in thrombus formation and ...
H, Kiss, C, Schneeberger, W, Tschugguel, H, Lass, J C, Huber, P, Husslein, M, Knöfler   +6 more
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Prolonged In Vivo Hypoxia Enhances Nitric Oxide Synthase Type I and Type III Gene Expression in Adult Rat Lung

American Journal of Respiratory Cell and Molecular Biology, 1995
Abstract Prolonged hypoxia in the adult rat causes a decline in endothelium-derived nitric oxide (NO) production in the pulmonary circulation. To evaluate whether this is related to a decrease in endothelial NO synthase (NOS-III) expression, we determined the effects of hypobaric hypoxia (7 or 21 days) on NOS-III gene expression in ...
P W, Shaul, A J, North, T S, Brannon, K, Ujiie, L B, Wells, P A, Nisen, C J, Lowenstein, S H, Snyder, R A, Star   +8 more
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Activation and dimerization of type III nitric oxide synthase by submicromolar concentrations of tetra hydrobiopterin in microsomal preparations from human primordial placenta

Placenta, 1997
We have found in a previous study that 5-50 microM tetrahydrobiopterin (BH4) stimulated 1.2-2.5-fold Ca(2+)-dependent nitric-oxide synthase (NOS) activity in homogenates prepared from primordial human placentae. Now we report on the dramatic, about sixfold, activating effect of BH4 on this activity measured in microsomal preparations.
M, Tóth, Z, Kukor, M, Sahin-Tóth
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Perivascular nerve fibres and endothelial cells of the rat basilar artery: immuno-gold labelling of antigenic sites for type I and type III nitric oxide synthase

Journal of Neurocytology, 1998
Ultrastructural localisation of type I (neuronal) and type III (endothelial) isoforms of nitric oxide synthase in perivascular nerve fibres (axons) and endothelial cells was studied in the Wistar rat cerebral basilar artery, using monoclonal antibodies either to type I or type III nitric oxide synthase and post-embedding colloidal-gold ...
A, Loesch, G, Burnstock
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