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Effects of Nitric Oxide Expression on Hearing Loss. [PDF]

open access: yesInt J Mol Sci
Cha YJ   +6 more
europepmc   +1 more source
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Role of Sp1 in Transcriptional Activation of Human Nitric Oxide Synthase Type III Gene

Biochemical and Biophysical Research Communications, 1995
Endothelial nitric oxide synthase (eNOS or NOS-III) is constitutively expressed. To elucidate the mechanism by which the basal expression of NOS-III gene is activated, we constructed in a luciferase vector, pXP1, serial 5'-deletion mutants of a 1.3-kb 5'-flanking fragment and transiently expressed them in cultured human endothelial cells.
J L, Tang   +3 more
openaire   +2 more sources

Nitric oxide synthase type I and type III gene expression are developmentally regulated in rat lung

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1994
The successful transition from fetal to neonatal life involves a marked decline in pulmonary vascular resistance which is modulated in part by endothelium-derived nitric oxide. To define the molecular processes which prepare the pulmonary circulation for nitric oxide mediation of vasodilatation at the time of birth, we determined the ontogeny of ...
A J, North   +7 more
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Regulation and Dysregulation of Constitutive Nitric Oxide Synthases Types I and III

1995
Mammalian cells synthesize nitric oxide (NO) from l-arginine by NO synthases (NOS), members of the cytochrome P450 gene family. NO represents the best understood member of a novel class of redox-active transmembrane and intracellular signaling molecules that may also include CO and oxygen radicals.
H H, Schmidt, H, Hofmann, P, Ogilvie
openaire   +2 more sources

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