Results 291 to 300 of about 116,978 (344)

Biallelic Variants in the DARS2 Gene as a Novel Cause of Axonal Charcot–Marie–Tooth Disease

Annals of Neurology, EarlyView.
Objective Charcot–Marie–Tooth (CMT) disease is a heterogeneous group of genetic neuropathies, with >90 genes identified. Several aminoacyl‐tRNA synthetases have been linked to CMT. DARS2, encoding the mitochondrial aspartyl‐tRNA synthetase, has been typically associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate ...
Berta Estévez‐Arias, Siiri Sarv, Nathalie Bonello‐Palot, Laura Carrera‐García, Carlos Ortez, Jesica Expósito‐Escudero, Delia Yubero, Jordi Muchart, Emilien Delmont, Eve Õiglane‐Shlik, Teele Meren, Sanna Puusepp, Ülle Murumets, Gajja S. Salomons, Bjarne Udd, Liis Väli, Lara Cantarero, Carsten G. Bönnemann, Andrés Nascimento, Santiago Ramón‐Maiques, Katrin Õunap, Janet Hoenicka, Daniel Natera‐de Benito, Francesc Palau   +23 more
wiley   +1 more source

A Study on the Aging Mechanism and Anti-Aging Properties of Nitrile Butadiene Rubber: Experimental Characterization and Molecular Simulation. [PDF]

Polymers (Basel)
Zhu M, Huang H, Li H, Huang G, Lan J, Fu J, Fan J, Liu Y, Ke Z, Guo X, Zhou H, Li Y.   +11 more
europepmc   +1 more source

Endogenously Triggered DNAzyme‐Based Nanostructures for Gene‐Combined Therapy

Advanced NanoBiomed Research, EarlyView.
DNAzymes show great promise for gene regulation and therapeutic use via controlled release triggered by endogenous factors. This review summarizes recent advances in designing and constructing nanoscale platforms enabling endogenously triggered release of DNAzyme.
Theoneste Muyizere, Julien Milon Essola, Eric Nyirimigabo, Janvier Mukiza, Jean Felix Mukerabigwi   +4 more
wiley   +1 more source

I‑GAT: Interpretable Graph Attention Networks for Ligand Optimization. [PDF]

ACS Omega
Mathew E, Emmitte KA, Liu J.
europepmc   +1 more source

Cupin‐Type Dimethylsulfoniopropionate Lyase from Pelagibacter ubique (DddKPu) Catalyzes Aza‐Michael Addition of Primary and Secondary Amines to Acrylic Acid

Angewandte Chemie, EarlyView.
A dimethylsulfoniopropionate lyase (DddK) was identified as an efficient aza‐Michaelase for the addition of amines to acrylate. Screening 74 amines with wild‐type DddK and its W26G variant yielded N‐substituted and N,N‐disubstituted β‐amino acids in 30%–93% isolated yield.
Diletta Arceri, Angela Mourelle, Teodor Parella, Jordi Bujons, Carlos J. Moreno, Pere Clapés   +5 more
wiley   +1 more source

Near-Infrared Coumarin-Hemicyanine Hybrid Dyes Bearing an Intramolecular Nucleophile for Activatable Fluorescence and Raman Imaging. [PDF]

Anal Chem
Fujioka H, Sakamoto R, Hiramatsu K, Murakami Y, Masaki M, Kawatani M, Matsumoto S, Kojima R, Urano Y, Kano H, Kamiya M.   +10 more
europepmc   +1 more source

Enhancing Mechanical Properties and Oil Resistance of Carbon Black/Hydrogenated Nitrile Butadiene Rubber Composites via Tea Polyphenol-Assisted Interfacial Modification. [PDF]

ACS Omega
Yin H, Nie J, Wang Y, Zhang S, Sun M, Tian Y, Fan C, He Q.   +7 more
europepmc   +1 more source

Probing the ferredoxin:hydrogenase electron transfer complex by infrared difference spectroscopy. [PDF]

Chem Sci
Sahin S, Brazard J, Zuchan K, Adachi TBM, Mühlenhoff U, Milton RD, Stripp ST.   +6 more
europepmc   +1 more source