Results 111 to 120 of about 50,424 (297)

The wider perspective: Barriers and recommendations for transfusion support for patients with sickle cell disease in low‐ and middle‐income countries

British Journal of Haematology, EarlyView.
Globally, sickle cell disease (SCD) is the most common inherited haemoglobinopathy. The highest burden of SCD is encountered in low‐ and middle‐income countries (LMICs), most of which lack the resources to contend with the disease. Blood transfusion remains central to the emergent treatment and prevention of complications of SCD.
Jeremy W. Jacobs, Luiz Amorim, France Pirenne, Claude Tayou, Ijele Adimora, Lydia H. Pecker, Aaron A. R. Tobian, Jeannie Callum, Julie Makani, Mark T. Gladwin, Meghan Delaney, Darrell J. Triulzi, Isaac Odame, Evan M. Bloch   +13 more
wiley   +1 more source

Reaction of the NAD(P)H:flavin oxidoreductase from Escherichia coli with NADPH and riboflavin: identification of intermediates [PDF]

Biochemistry, American Chemical Society, 1998, 37, pp.11879-87, 2014
Flavin reductase catalyzes the reduction of free flavins by NAD(P)H. As isolated, Escherichia coli flavin reductase does not contain any flavin prosthetic group but accommodates both the reduced pyridine nucleotide and the flavin substrate in a ternary complex prior to oxidoreduction.
arxiv  

Genome sequence of Rhizobium sullae HCNT1 isolated from Hedysarum coronarium nodules and featuring peculiar denitrification phenotypes [PDF]

, 2018
The genome sequence of Rhizobium sullae strain HCNT1, isolated from root nodules of the legume Hedysarum coronarium growing in wild stands in Tuscany, Italy, is described here. Unlike other R.
Basaglia, M., Campanaro, S., Casella, S., da Silva Duarte, V., de Diego-Diaz, B., Favaro, L., Squartini, A., Treu, L.   +7 more
core   +2 more sources

Denitrification, activity of bacterial flocs, and growth of a filamentous bacterium in relation with the bulking of activated sludge [PDF]

, 1978
Activated sludge with poor settling characteristics is caught under the term "bulking" sludge. Various types of bulking activated sludge can be distinguished.1) Sludge containing an abundance of filamentous microorganisms.2) Sludge, characterized by ...
Krul, J.M.
core   +1 more source

A dedicated haem lyase is required for the maturation of a novel bacterial cytochrome c with unconventional covalent haem binding [PDF]

, 2007
In bacterial c-type cytochromes, the haem cofactor is covalently attached via two cysteine residues organized in a haem c-binding motif. Here, a novel octa-haem c protein, MccA, is described that contains only seven conventional haem c-binding motifs ...
Allen J.W.A., Allen J.W.A., Allen J.W.A., Allen J.W.A., Beliaev A.S., de Vitry C., Dobbin P.S., Hartshorne S., Kroger A., Lorenzen J.P., Mileni M., Moore G.R., Mowat C.G., Scott R.A., Thony-Meyer L., Walker F.A., Wood P.M., Yang F.   +17 more
core   +1 more source

Redox Reactivity of Nonsymbiotic Phytoglobins towards Nitrite

Molecules
Nonsymbiotic phytoglobins (nsHbs) are a diverse superfamily of hemoproteins grouped into three different classes (1, 2, and 3) based on their sequences.
Cezara Zagrean-Tuza, Galaba Pato, Grigore Damian, Radu Silaghi-Dumitrescu, Augustin C. Mot   +4 more
doaj   +1 more source

A functional description of CymA, an electron-transfer hub supporting anaerobic respiratory flexibility in Shewanella [PDF]

, 2012
CymA (tetrahaem cytochrome c) is a member of the NapC/NirT family of quinol dehydrogenases. Essential for the anaerobic respiratory flexibility of shewanellae, CymA transfers electrons from menaquinol to various dedicated systems for the reduction of ...
Butt, Julea N., Bye, Jordan, Cheesman, Myles R., Fredrickson, Jim, Jeuken, Lars J. C., Lowe, Thomas G., Marritt, Sophie J., McMillan, Duncan G. G., Richardson, David J., Shi, Liang, Zachara, John   +10 more
core   +1 more source

The radical SAM enzyme NirJ cleaves off two propionate side chains with the release of acrylate during heme d1 biosynthesis

The FEBS Journal, EarlyView.
The radical SAM enzyme NirJ is responsible for the removal of two propionate side chains from its substrate didecarboxy‐siroheme during heme d1 biosynthesis. The cleavage products of the NirJ reaction were not known so far. In this study, it is shown that acrylate is formed as the reaction byproduct and that the resulting tetrapyrrole product carries ...
Heike Meyer, Maren H. Hoock, Kai Zwara, Sören Jahn, Volker Schünemann, Gunhild Layer   +5 more
wiley   +1 more source

Niche differentiation in nitrogen metabolism among methanotrophs within an operational taxonomic unit [PDF]

, 2014
Background: The currently accepted thesis on nitrogenous fertilizer additions on methane oxidation activity assumes niche partitioning among methanotrophic species, with activity responses to changes in nitrogen content being dependent on the in situ ...
Boon, Nico, De Vos, Paul, Heylen, Kim, Hoefman, Sven, van der Ha, David, Vandamme, Peter   +5 more
core   +3 more sources

Identification of CO‐binding modes in the CuB site of bovine cytochrome c oxidase by spatial mapping of binding energy

The FEBS Journal, EarlyView.
Quantum simulations of the catalytic center (CuB) of cytochrome c oxidase, driving the electron transport system, revealed a crucial role of Val243 in modulation of ligand binding. Val243‐driven interaction facilitates hybridization between CO and Fe orbitals, thus highlighting Val243's impact on electronic structure and ligand dynamics.
Jiyoung Kang, Toru Matsuoka, Masaru Tateno   +2 more
wiley   +1 more source