Results 151 to 160 of about 2,815 (210)
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On the mutagenicity of nitrofurans
Mutation Research, 1974Summary 22 nitrofurans were tested for ability to induce revertants of E. coli WP2 and its uvrA - derivative from tryp - to tryp +. All proved to be mutagnic while two furan analogues (lacking the nitro- group) proved to be inactive. Test strains containing exrA - or recA - genes were not induced to mutate, suggesting that mutants arise in the
D R, McCalla, D, Voutsinos
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1967
Publisher Summary This chapter explores that chemotherapeutic agents are defined as chemical compounds that affect causative organisms without injuring the patient. The nitrofurans, which do not occur in nature and belong to this large group of compounds, are characterized by a heterocyclic ring consisting of four carbon atoms and one of oxygen; an ...
K. Miura, H.K. Reckendorf
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Publisher Summary This chapter explores that chemotherapeutic agents are defined as chemical compounds that affect causative organisms without injuring the patient. The nitrofurans, which do not occur in nature and belong to this large group of compounds, are characterized by a heterocyclic ring consisting of four carbon atoms and one of oxygen; an ...
K. Miura, H.K. Reckendorf
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Oxidative Metabolites of 5-Nitrofurans
Pharmacology, 2008We synthesized the 4-hydroxy derivatives of nitrofurazone, furazolidone and nitrofurantoin. Then we dosed rats orally with these antibiotics and isolated the intensely yellow, polar metabolites from their urine. A comparison of the ultraviolet and nuclear magnetic resonance spectra of these metabolites with the corresponding synthetic derivatives ...
A J, Streeter, T R, Krueger, B A, Hoener
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Interaction of nitrofurans with glutathione reductase
Biochimica et Biophysica Acta (BBA) - General Subjects, 1991Nitrofurans inhibit the oxidation of NADPH by glutathione, catalyzed by yeast glutathione reductase (EC 1.6.4.2). acting as uncompetitive incomplete inhibitors for NADPH and glutathione. The quinoline-substituted nitrofurans were the most effective inhibitors.
N K, Cénas +3 more
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Effect of activated nitrofurans on DNA
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1975Enzymically activated nitrofurazone reacts with co-valently closed circular DNA (derived from Escherichia coli minicells carrying lambdadv) to give at least two kinds of damage: breaks which are detected on neutral sucrose gradients and alkali-labile lesions in DNA which are converted to breaks when the DNA is subsequently Treated with alkali.
Y, Tu, D R, McCalla
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Polyneuropathy Associated with Nitrofuran Therapy
Archives of Neurology, 1960Furacin (nitrofurazone) has been used for the treatment of metastatic testicular carcinoma because of the disintegration of seminiferous epithelium produced in animals by nitrofurans. 1 Although a beneficial effect on the malignancy has occurred, a severe polyneuropathy has usually developed. Wildermuth's patient, who had received 49 gm.
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Paper chromatography of nitrofuran derivatives
Journal of Chromatography A, 1966Some investigations have been carried out on the paper chromatography of a group of new nitrofuran derivatives, along with three known preparations of the same group, viz. furacin, furadantin and furoxone. Nine solvent systems were employed, and it was established that for the identification and separation of this group of compounds, together with the ...
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Metabolic Degradation of the Nitrofurans
Journal of Medicinal and Pharmaceutical Chemistry, 1960H E, PAUL +3 more
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