Results 161 to 170 of about 4,061 (207)
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Oxidative Metabolites of 5-Nitrofurans
Pharmacology, 1988We synthesized the 4-hydroxy derivatives of nitrofurazone, furazolidone and nitrofurantoin. Then we dosed rats orally with these antibiotics and isolated the intensely yellow, polar metabolites from their urine. A comparison of the ultraviolet and nuclear magnetic resonance spectra of these metabolites with the corresponding synthetic derivatives ...
A J, Streeter, T R, Krueger, B A, Hoener
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Aquatic Photochemistry of Nitrofuran Antibiotics
Environmental Science & Technology, 2006The aquatic photochemical degradation of a class of pharmaceuticals known as the nitrofuran antibiotics (furaltadone, furazolidone, and nitrofurantoin) was investigated. Direct photolysis is the dominant photodegradation pathway for these compounds with the formation of a photostationary state between the syn and the anti isomers occurring during the ...
Betsy L, Edhlund +2 more
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1967
Publisher Summary This chapter explores that chemotherapeutic agents are defined as chemical compounds that affect causative organisms without injuring the patient. The nitrofurans, which do not occur in nature and belong to this large group of compounds, are characterized by a heterocyclic ring consisting of four carbon atoms and one of oxygen; an ...
K. Miura, H.K. Reckendorf
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Publisher Summary This chapter explores that chemotherapeutic agents are defined as chemical compounds that affect causative organisms without injuring the patient. The nitrofurans, which do not occur in nature and belong to this large group of compounds, are characterized by a heterocyclic ring consisting of four carbon atoms and one of oxygen; an ...
K. Miura, H.K. Reckendorf
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On the mutagenicity of nitrofurans
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1974Summary 22 nitrofurans were tested for ability to induce revertants of E. coli WP2 and its uvrA - derivative from tryp - to tryp +. All proved to be mutagnic while two furan analogues (lacking the nitro- group) proved to be inactive. Test strains containing exrA - or recA - genes were not induced to mutate, suggesting that mutants arise in the
D R, McCalla, D, Voutsinos
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Paper chromatography of nitrofuran derivatives
Journal of Chromatography A, 1966Some investigations have been carried out on the paper chromatography of a group of new nitrofuran derivatives, along with three known preparations of the same group, viz. furacin, furadantin and furoxone. Nine solvent systems were employed, and it was established that for the identification and separation of this group of compounds, together with the ...
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Polyneuropathy Associated with Nitrofuran Therapy
Archives of Neurology, 1960Furacin (nitrofurazone) has been used for the treatment of metastatic testicular carcinoma because of the disintegration of seminiferous epithelium produced in animals by nitrofurans. 1 Although a beneficial effect on the malignancy has occurred, a severe polyneuropathy has usually developed. Wildermuth's patient, who had received 49 gm.
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Antimicrobials. New nitrofuran derivatives
Journal of Medicinal Chemistry, 1973E, Szarvasi +2 more
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