Results 91 to 100 of about 1,712,466 (298)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Synthesis of cyclic carbonates by CO2 cycloaddition with epoxides: recent advances, challenges, and perspectives

Green Chemical Engineering
The catalytic conversion of CO2 into functionalized chemical products has evolved into a pivotal scientific frontier, garnering substantial research investment from multidisciplinary domains.
Decun Luo, Shilong Xie, Zhun Hu, Chun-Ran Chang   +3 more
doaj   +1 more source

CoupModel (v6.0): an ecosystem model for coupled phosphorus, nitrogen and carbon dynamics – evaluated against empirical data from a climatic and fertility gradient in Sweden

, 2020
Hongxing He, Per‐Erik Jansson, Annemieke I. Gärdenäs   +2 more
openalex   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

3,4-Bis(3-tetrazolylfuroxan-4-yl)furoxan: A Linear C–C Bonded Pentaheterocyclic Energetic Material with High Heat of Formation and Superior Performance

ACS Omega, 2020
Lianjie Zhai, Fuqiang Bi, Junlin Zhang, Jiarong Zhang, Xiangzhi Li, Bozhou Wang, Sanping Chen   +6 more
doaj   +1 more source

Modular synthesis of CF2-containing compounds with PhSO2CF2H reagent through difluoromethylene radical anion synthon strategy

Nature Communications
Difluoromethylene moiety has gained widespread applications in pharmaceuticals, agrochemicals, and materials owing to its augmented lipophilicity and being bioisosteric to ethereal oxygen.
Shuo Sun, Rulong Jia, Xin Zhou, Zhongyi Wang, Jian Rong, Chuanfa Ni, Jinbo Hu   +6 more
doaj   +1 more source

Erratum to: “Synthesis and Study of New Nitrogen-Containing Heterocycles Based on Glycoluril Derivatives” [PDF]

, 2015
L. K. Sal’keeva, А. А. Бакибаев, P. Voitiček, A. K. Shibaeva, E. K. Taishibekova, A. A. Zhortarova, L. M. Sugralina   +6 more
openalex   +1 more source

Review for "Ericoid mycorrhizal shrubs alter the relationship between tree mycorrhizal dominance and soil carbon and nitrogen"

, 2021

openalex   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source