Results 61 to 70 of about 2,207,670 (307)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Nitrogen Isotopes in the Global Ocean [PDF]
, 2013 Nitrogen is an essential nutrient for life. Its low abundance throughout much of the sunlit surface ocean limits the growth of primary producers that form the base of ocean ecosystems.
Somes, Christopher J. +1 more
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Single atom catalysts for electrocatalytic C–N coupling: From dynamic mechanism to rational design
Nano ResearchElectrocatalysis for C–N coupling reactions (EcnRR) plays a crucial role in the synthesis of various organic molecules. However, the C–N coupling process is inherently complex and kinetically sluggish. Single atom catalysts (SACs), with their high atomic
Chao Zhao +5 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
THE DISINTEGRATION OF NITROGEN [PDF]
School Science and Mathematics, 1920 n ...
openaire +2 more sources
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Effects of ageing and cultivation of grassland on soil nitrogen [PDF]
, 2001 Nitrogen losses from agriculture in the Netherlands have to be strongly decreased because of national and international policy (e.g. Nitrate Directive). The cultivation of grassland when grassland is renewed or converted into arable land may enhance net ...
Velthof, G.L., Oenema, O.
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Communications ChemistryHydrogen-assisted dehydrochlorination process (HaDHC) is an attractive route for the production of fluorine-containing olefins under relatively mild conditions, so far lacking the highly efficient metal-based catalysts and their design strategy. Here, we
Chen Yang +8 more
doaj +1 more source