Results 241 to 250 of about 123,348 (312)

Piezo1 Activation Improves NSCLC Liver Metastasis Immunotherapy by Overriding Matrix Stiffness‐Mediated Bimodal PD‐L1/CXCL10 Regulation

open access: yesAdvanced Science, EarlyView.
This study demonstrates that Piezo1 activation enhances FAK‐YAP‐mediated upregulation of PD‐L1 and CXCL10, thereby promoting an immunotherapy‐responsive tumor microenvironment in NSCLC. Cyclic stretch modulates the PD‐L1/CXCL10 response to ECM stiffness, reshaping their expression dynamics.
Tian Zhang   +11 more
wiley   +1 more source

Upcycling of Waste Fluororubber to Photocurable High‐Performance Vinyl‐Terminated Liquid Fluororubber by Multifield Coupling One‐Pot Stepwise Reactions

open access: yesAdvanced Science, EarlyView.
Herein, waste fluororubbers undergo controlled oxidative degradation induced by alkali and hydrogen peroxide to yield carboxyl terminated liquid fluororubbers. Subsequently, condensation reaction system efficiently converts carboxyl groups into photoreactive vinyl groups.
Donghan Li   +12 more
wiley   +1 more source

Coactosin‐Like Protein Reduces Prostaglandin D2 Production in Alveolar Macrophages and Alleviates Allergic Airway Inflammation

open access: yesAdvanced Science, EarlyView.
Coactosin‐like protein inhibits prostaglandin D₂ (PGD2) secretion by modulating alveolar macrophage polarization, thereby suppressing activation of the PGD2 receptor CRTH2 in Th2‐associated immune cells and alleviating allergic airway inflammation.
Li‐Long Pan   +12 more
wiley   +1 more source

Activity‐Selectivity Trends in Electrochemical Urea Synthesis: Co‐Reduction of CO2 and Nitrates Over Single‐Site Catalysts

open access: yesAdvanced Science, EarlyView.
In this work, a series of single‐site metal phthalocyanine catalysts (MPcs (M = Zn, Co, Ni, Cu, and Fe)) are screened to learn their activity‐selectivity relationship in the co‐reduction reaction of CO2 and nitrates toward urea formation, which can be significantly promoted by enhanced adsorption of *HOOCNO, reduced adsorptions of *N and *COOH, and ...
Qinglan Zhao   +11 more
wiley   +1 more source

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