Results 271 to 280 of about 127,598 (336)

Enhanced the Trans‐Cleavage Activity of CRISPR‐Cas12a Using Metal‐Organic Frameworks as Stimulants for Efficient Electrochemical Sensing of Circulating Tumor DNA

open access: yesAdvanced Science, EarlyView.
This work designs manganese metal‐organic frameworks (Mn‐MOFs) co‐assembled with Cas12a/crRNA, enabling rapid release of Mn2⁺ under mild conditions. The MOFs‐induced proximity effect sustains Mn2⁺‐Cas12a/crRNA interactions, enhancing the trans‐cleavage activity of complex available to develop an electrochemical biosensor based on Mn‐MOFs‐enhanced ...
Shuai Wu   +8 more
wiley   +1 more source

Ultrasound‐Responsive 4D Bioscaffold for Synergistic Sonopiezoelectric‐Gaseous Osteosarcoma Therapy and Enhanced Bone Regeneration

open access: yesAdvanced Science, EarlyView.
An acoustic‐responsive therapeutic platform for synergistic sonopiezoelectric‐gaseous osteosarcoma therapy and bone regeneration is fabricated through the joint loading of few‐layer black phosphorus nanosheets and S‐Nitroso‐L‐glutathione onto the 3D‐printed bioactive glass scaffolds.
Haoyu Fang   +8 more
wiley   +1 more source

Inorganic nitrogen inhibits symbiotic nitrogen fixation through blocking NRAMP2-mediated iron delivery in soybean nodules. [PDF]

open access: yesNat Commun
Zhou M   +15 more
europepmc   +1 more source

Plac1+ Tumor Cell‐Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer

open access: yesAdvanced Science, EarlyView.
Meng et al. screen genes in the CTAs family and find Plac1 is specifically expressed in head and neck squamous cell carcinoma (HNSCC) cells. They reveal that Plac1 expression promotes HNSCC progression directly by activating PI3K/AKT signaling pathway.
Xiaoyan Meng   +8 more
wiley   +1 more source

A Real‐Time Cell Death Self‐Reporting Theranostic Agent for Dynamic Optimization of Photodynamic Therapy

open access: yesAdvanced Science, EarlyView.
A cell death self‐reporting photodynamic theranostic nanoagent (CDPN) is developed that integrates photodynamic therapy (PDT) with real‐time K⁺ imaging to provide timely feedback on treatment responses. This approach enables the optimization of the drug‐light interval (DLI), a critical factor in PDT, resulting in significantly enhanced antitumor ...
Wei Bian   +9 more
wiley   +1 more source

Dynamic nitrogen fixation in an aerobic endophyte of Populus. [PDF]

open access: yesISME J
Sher AW   +15 more
europepmc   +1 more source

OcuPair, a Novel Photo‐crosslinkable PAMAM Dendrimer‐Hyaluronic Acid Hydrogel Bandage/Bioadhesive for Corneal Injuries and Temporary Corneal Repair

open access: yesAdvanced Science, EarlyView.
A schematic diagram showing the OcuPair adhesive hydrogel formulation loaded into the final delivery device and applied over the full‐thickness corneal wound in an in vivo rabbit model of corneal injury followed by in situ crosslinking to form a transparent hydrogel bandage sealing the wound.
Siva P. Kambhampati   +6 more
wiley   +1 more source

A Bayesian approach for estimating the uncertainty on the contribution of nitrogen fixation and calculation of nutrient balances in grain legumes. [PDF]

open access: yesPlant Methods
Palmero F   +7 more
europepmc   +1 more source

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