Results 121 to 130 of about 130,387 (339)

Metabologenomic Hallmark‐Based Discovery of Bacterial Thioamides as a New Lead against Drug‐Resistant Pancreatic Cancer

Advanced Science, EarlyView.
A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du, Eun Seo Bae, Thinh T. M. Bui, Seok Beom Lee, Dahan Kim, Jin‐Gyeong Park, Yongjoo Park, Soo Yeon Park, Sangwook Kang, Beomsu Lee, Daniel Shin, Yun Pyo Kang, In‐Gyun Lee, Dae‐Duk Kim, Seokhee Kim, Suckchang Hong, Kyuho Moon, Sang Kook Lee, Dong‐Chan Oh   +18 more
wiley   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

A framework for tracing the sources of nitrate in surface water through remote sensing data coupled with machine learning

npj Clean Water
As an integral component of the global nitrogen cycle, nitrate are readily transferred from urban sewage discharge, agricultural activities, and atmospheric sedimentation to surface water. This paper introduces an innovative framework that combines multi-
Di Tian, Xinfeng Zhao, Lei Gao, Tao Jiang, Zuobing Liang, Zaizhi Yang, Pengcheng Zhang, Qirui Wu, Kun Ren, Chenchen Yang, Rui Li, Shaoheng Li, Yingjie Cao, Yingxue Xuan, Jianyao Chen, Aiping Zhu   +15 more
doaj   +1 more source

A New foodweb based on microbes in calcitic caves: The Cansiliella (Beetles) case in Northern Italy [PDF]

International Journal of Speleology, 2011
The troglobitic beetle, Cansiliella servadeii (Leptodirini), has specialized mouthparts modified for browsing and feeding under percolating water on moonmilk, a speleothem formation in Grotta della Foos, Italy. Results from analyses of stable isotopes of
Paoletti Maurizio G., Beggio Mattia, Dreon Angelo Leandro, Pamio Alberto, Gomiero Tiziano, Brilli Mauro, Dorigo Luca, Concheri Giuseppe, Squartini Andrea, Summers Engel Annette   +9 more
doaj  

Dual Optical Marker Raman Characterization of Strained GaN-channels on AlN Using AlN/GaN/AlN Quantum Wells and 15N Isotopes

, 2015
This work shows that the combination of ultrathin highly strained GaN quantum wells embedded in an AlN matrix, with controlled isotopic concentrations of Nitrogen enables a dual marker method for Raman spectroscopy.
Ganguly, Satyaki, Hu, Zongyang, Jena, Debdeep, Li, Guowang, Mintairov, Alexander, Protasenko, Vladimir, Qi, Meng, Song, Bo, Verma, Jai, Xing, Huili Grace, Yan, Xiaodong, Zhao, Pei, Zhu, Mingda   +12 more
core   +1 more source

Global Nitrogen Deposition Promotes Carbon Sink Formation in Terrestrial Ecosystems

Advanced Science, EarlyView.
Nitrogen deposition alleviates ecosystem N limitation and enhances carbon sinks. Using 829 observations, we show 36% of deposited N is retained globally (39.15 Tg N yr−1), with distinct NHx and NOy contributions. This retention drives a terrestrial C sink of 0.88 Pg C yr−1 (25.48%), highlighting the importance of pool‐specific C:N stoichiometry ...
Lei Li, Mingyu Xie, Nan Jia, Li‐Dong Mo, Qiang Yu, Fanjiang Zeng, Xiangyi Li   +6 more
wiley   +1 more source

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

Advanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza, Sheila Dakhel Plaza, Samuele Cazzamalli, Andrea Ciamarone, Andrea Galbiati, Riccardo Stucchi, Frederik Peissert, Emanuele Puca, Dario Neri, Ettore Gilardoni   +9 more
wiley   +1 more source

Microscale Hydrogen and Nitrogen Isotopic Distributions in Pristine CM Chondrite Asuka 12236 [PDF]

, 2020
L. R. Nittler, C. M. O'd. Alexander, Maximilien Verdier‐Paoletti   +2 more
openalex   +1 more source

Axial F–Bi–Ov Electron Pump Drives Continuous Reconfiguration of Bi Sites for Efficient Photocatalytic N2 Reduction

Advanced Science, EarlyView.
Axial Fluorine and Light‐Induced Oxygen Vacancies Synergize as an Electron Pump to Lower N2 Activation Energy and Enable Sustained NH3 Synthesis on FBWO. ABSTRACT The electronic structure precision of single‐atom catalysts (SACs) represents a decisive factor limiting advancements in photocatalytic nitrogen reduction (NRR) efficiency.
Xiao Ge, Xinyi Wu, Hao‐tong Li, Xinya Liu, Jie‐jie Chen, Yuan Min, Xiaozhi Wang   +6 more
wiley   +1 more source

FIXATION OF ISOTOPIC NITROGEN BY CLOSTRIDIUM [PDF]

Journal of Bacteriology, 1949
E D, ROSENBLUM, P W, WILSON
openaire   +3 more sources