3D- and 2D-QSAR models’ study and molecular docking of novel nitrogen-mustard compounds for osteosarcoma [PDF]
Frontiers in Molecular Biosciences, 2023 Background: The dipeptide-alkylated nitrogen-mustard compound is a new kind of nitrogen-mustard derivative with a strong anti-tumor activity, which can be used as a potential anti-osteosarcoma chemotherapy drug.Objective: 2D- and 3D-QSAR (structure ...
Wenkun Zhuo +4 more
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Study on the Reaction Kinetics of Sulfur Mustard, Nitrogen Mustard and Their Chosen Analogues with Sodium Ethoxide [PDF]
MoleculesThe course and kinetics of the reactions of sulfur mustard, nitrogen mustard and their selected analogues with sodium ethoxide were studied using a gas chromatograph coupled with a mass spectrometer.
Klaudia Kozon +3 more
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Eruptive Cherry Angiomas After Nitrogen Mustard Treatment for Vitiligo [PDF]
Clinical, Cosmetic and Investigational DermatologyHuiying Wang,1 Ruzhi Zhang2 1Department of Dermatology, The Third Affiliated Hospital of Soochow University, Changzhou, People’s Republic of China; 2Department of Dermatology, The Second Affiliated Hospital of Wannan Medical College, Wuhu, People’s ...
Wang H, Zhang R
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Melatonin as Modulator for Sulfur and Nitrogen Mustard-Induced Inflammation, Oxidative Stress and DNA Damage: Molecular Therapeutics [PDF]
Antioxidants, 2023 Sulfur and nitrogen mustards, bis(2-chloroethyl)sulfide and tertiary bis(2-chloroethyl) amines, respectively, are vesicant warfare agents with alkylating activity.
Eva Ramos +10 more
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Method for the synthesis of flavonoid nitrogen mustard derivatives [PDF]
MethodsX, 2020 We have prepared a kind of new type of flavonoid nitrogen mustard derivatives with broad-spectrum antitumor activity, which have not been reported in the literature.
Jinglei Song +3 more
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Senescence and Stress Signaling Pathways in Corneal Cells After Nitrogen Mustard Injury [PDF]
CellsMustard gas keratopathy (MGK), a complication of exposure to sulfur mustard, is a blinding ocular surface disease involving key cellular pathways, including apoptosis, oxidative stress, and inflammation.
Khandaker N. Anwar +13 more
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Therapeutic Potential of Nitrogen Mustard Based Hybrid Molecules [PDF]
Frontiers in Pharmacology, 2018 As medicine advances, cancer is still among one of the major health problems, posing significant threats to human health. New anticancer agents features with novel scaffolds and/or unique mechanisms of action are highly desirable for the treatment of ...
Yiming Chen +3 more
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Synthesis of nitrogen mustard-based fluorophores for cell imaging and cytotoxicity studies [PDF]
Journal of Advanced Pharmaceutical Technology & Research, 2023 Nitrogen mustards are important alkylating anticancer drugs used for neoplasms treatment. However, little research about the integration of luminophore into nitrogen mustard-based compounds for both imaging and therapeutic application was reported.
Yuanwei Liang +5 more
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A novel therapy to ameliorate nitrogen mustard-induced limbal stem cell deficiency using lipoprotein-like nanoparticles [PDF]
npj Regenerative MedicineChronic corneal inflammation, a component of sulfur mustard (SM) and nitrogen mustard (NM) injuries frequently leads to limbal stem cell deficiency (LSCD), which can compromise vision.
Elif Kayaalp Nalbant +18 more
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Pharmacological Reviews, 2022 The nitrogen mustards are powerful cytotoxic and lymphoablative agents and have been used for more than 60 years. They are employed in the treatment of cancers, sarcomas, and hematologic malignancies. Cyclophosphamide, the most versatile of the nitrogen mustards, also has a place in stem cell transplantation and the therapy of autoimmune diseases ...
Highley, Martin S. +4 more
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