Results 1 to 10 of about 2,545 (184)

Utility of T-cell immunosequencing in distinguishing mycosis fungoides progression from treatment related cutaneous adverse events [PDF]

Frontiers in Medicine, 2023
Cutaneous adverse events of both topical and systemic drugs in patients with mycosis fungoides (MF) present a diagnostic challenge as it is often difficult to distinguish drug associated rash from disease progression in the skin.
Safiyyah Bhatti, Safiyyah Bhatti, Daniel Joffe, Lauren Banner, Sahithi Talasila, Jenna Mandel, Jason Lee, Pierluigi Porcu, Neda Nikbakht   +8 more
doaj   +2 more sources

Mechlorethamine

, 2006
James L. Schardein, Orest T. Macina
europepmc   +6 more sources

HPLC-UV, MALDI-TOF-MS and ESI-MS/MS analysis of the mechlorethamine DNA crosslink at a cytosine-cytosine mismatch pair. [PDF]

PLoS ONE, 2011
Mechlorethamine [ClCH(2)CH(2)N(CH(3))CH(2)CH(2)Cl], a nitrogen mustard alkylating agent, has been proven to form a DNA interstrand crosslink at a cytosine-cytosine (C-C) mismatch pair using gel electrophoresis.
Pornchai Rojsitthisak, Nutthapon Jongaroonngamsang, Rebecca M Romero, Ian S Haworth   +3 more
doaj   +2 more sources

A practical and safer model of nitrogen mustard injury in cornea. [PDF]

PLoS ONE
PurposeSulfur mustard (SM) is an alkylating agent used in warfare and terrorism that inflicts devastating ocular injuries. Although the clinical symptoms are well described, the underlying mechanisms are not fully understood, hindering the development of
Ana M Sandoval-Castellanos, Yao Ke, Tiffany M Dam, Emanual Michael Maverakis, Mark J Mannis, Xiao-Jing Wang, Min Zhao   +6 more
doaj   +2 more sources

Skin-Directed Therapies in Mycosis Fungoides: An Update [PDF]

Dermatology and Therapy
Mycosis fungoides (MF) is the most common subtype of cutaneous T cell lymphoma (CTCL), characterized by monoclonal proliferation of malignant T cells primarily involving the skin.
Maciej Tota, Magdalena Łyko, Piotr Misiąg, Julia Łacwik, Julia Laska, Karol Biliński, Julita Kulbacka, Alina Jankowska-Konsur   +7 more
doaj   +2 more sources

In Vivo Evidence of Melatonin’s Protective Role in Alkylating-Agent-Induced Pulmonary Toxicity: A Systematic Review [PDF]

Antioxidants
Alkylating agents, historically employed as chemical warfare agents and currently used as chemotherapeutic drugs, are known to induce significant pulmonary toxicity. Current clinical interventions often fail to fully prevent or reverse these pathological
Emma Sola, Jose A. Morales-García, Francisco López-Muñoz, Eva Ramos, Alejandro Romero   +4 more
doaj   +2 more sources

DFT studies of metal oxide nanocluster as a possible drug delivery system for mechlorethamine [PDF]

BMC Chemistry
This study examined the adsorption of the mechlorethamine (ME) anti-cancer drug loaded upon Mg12O12 nanocage using DFT: B3LYP (6-31G* and 6-311G** basis set) and B3PW91 (6-31G* basis set) calculations.
Shahnaz Azari gharelar, Shiva Masoudi, Nasrin Masnabadi, Mohammad Hadi Ghasemi   +3 more
doaj   +2 more sources

THE RISK OF THERAPY-RELATED MYELODYSPLASIA/ACUTE MYELOID LEUKEMIA IN HODGKIN LYMPHOMA HAS SUBSTANTIALLY DECREASED IN THE ABVD ERA ABOLISHING MECHLORETHAMINE AND PROCARBAZINE AND LIMITING VOLUMES AND DOSES OF RADIOTHERAPY

Mediterranean Journal of Hematology and Infectious Diseases, 2012
Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related ...
Ercole Brusamolino, Manuel Gotti, Valeria Fiaccadori   +2 more
doaj   +4 more sources

Clinical potential of mechlorethamine gel for the topical treatment of mycosis fungoides-type cutaneous T-cell lymphoma: a review on current efficacy and safety data

Drug Design, Development and Therapy, 2018
Kendall Liner,1 Celeste Brown,2 Laura Y McGirt3 1Division of Dermatology, Medical College of Georgia at Augusta Health, Augusta, GA, USA; 2School of Medicine, University of North Carolina at Chapel Hill, Carolinas Medical Center, Charlotte, NC, USA ...
Liner K, Brown C, McGirt LY
doaj   +1 more source

Mechlorethamine Hydrochloride

Archives of Surgery, 1964
The use of chemotherapeutic agents as an adjunct to operative management of malignant disease is receiving considerable attention in current cancer research. Since the effects of these highly toxic drugs are not entirely limited to neoplastic tissue, however, knowledge of their effects on normal healing of wounds would be valuable.
C G, LONGENECKER, E T, KREMENTZ
openaire   +3 more sources