Results 41 to 50 of about 2,699 (183)

Topical Mechlorethamine Restores Autoimmune-Arrested Follicular Activity in Mice with an Alopecia Areata-Like Disease by Targeting Infiltrated Lymphocytes [PDF]

, 2003
Alopecia areata is an autoimmune disease targeted at hair follicles with infiltrated T lymphocytes probably playing an important role in the pathogenesis. It was reported in 1985 that mechlorethamine was effective on alopecia areata patients.
Shapiro, Jerry, Bernardo, O, Chung, Stephen, Lui, H, Chen, Yongliang, Tang, Liren, Chen, Y, Chung, S, Lui, Harvey, Bernardo, Olga, Cao, Liping, Sundberg, John P., Cao, L, Sundberg, J P, Shapiro, J, Tang, L   +15 more
core   +1 more source

Mechlorethamine-Induced DNA–Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells

, 2016
Antitumor nitrogen mustards, such as bis(2-chloroethyl)methylamine (mechlorethamine), are useful chemotherapeutic agents with a long history of clinical application. The antitumor effects of nitrogen mustards are attributed to their ability to induce DNA–
Natalia Y. Tretyakova (1330866), Simona G. Codreanu (2195107), Erin D. Michaelson-Richie (1962133), Daniel C. Liebler (1264215), Rachel L. Loeber (2195104), Xun Ming (1311798), Colin Campbell (527529)   +6 more
core   +2 more sources

NAD⁺ Acts as a Protective Factor in Cellular Stress Response to DNA Alkylating Agents

Cells, 2023
Sulfur mustard (SM) and its derivatives are potent genotoxic agents, which have been shown to trigger the activation of poly (ADP-ribose) polymerases (PARPs) and the depletion of their substrate, nicotinamide adenine dinucleotide (NAD+).
Joanna Ruszkiewicz, Ylea Papatheodorou, Nathalie Jäck, Jasmin Melzig, Franziska Eble, Annika Pirker, Marius Thomann, Andreas Haberer, Simone Rothmiller, Alexander Bürkle, Aswin Mangerich   +10 more
doaj   +1 more source

Depilatory double‐disc mouse model for evaluation of vesicant dermal injury pharmacotherapy countermeasures

Animal Models and Experimental Medicine, 2023
Background Sulfur mustard (SM) is a chemical warfare vesicant that severely injures exposed eyes, lungs, and skin. Mechlorethamine hydrochloride (NM) is widely used as an SM surrogate.
Tomas L. Roldan, Shike Li, Jeffrey D. Laskin, Dayuan Gao, Patrick J. Sinko   +4 more
doaj   +1 more source

Life-Cycle-Dependent Toxicities of Mono- and Bifunctional Alkylating Agents in the 3R-Compliant Model Organism C. elegans

Cells, 2023
Caenorhabditis elegans (C. elegans) is gaining recognition and importance as an organismic model for toxicity testing in line with the 3Rs principle (replace, reduce, refine). In this study, we explored the use of C.
Joanna Ruszkiewicz, Lisa Endig, Ebru Güver, Alexander Bürkle, Aswin Mangerich   +4 more
doaj   +1 more source

Melanogenesis From Topical Mechlorethamine And Analogues In Skin Of Hairless Mice And In Vitiligo [PDF]

, 1975
Progressive repigmentation occurred in vitiliginous skin of two patients topically treated with aqueous solutions of mechlorethamine. Hairless mice were found to provide what seems to be a satisfactory cutaneous system for evaluating potential ...
Yu, R J, Van scott, E J, Van Scott, E.J., Yu, R.J.   +3 more
core   +1 more source

Nitrogen Mustard (Mechlorethamine) and UVB Photocarcinogenesis: A Dose Response Effect [PDF]

, 1984
The effects of UVB energy and nitrogen mustard (mechlorethamine, HN2) on tumor formation in the hairless mouse skin was examined. Twice weekly applications of HN2 produced tumors in 34% of the mice.
Epstein, John H., John H. Epstein
core   +1 more source

Development and optimization of a mechlorethamine topical formulation utilizing a model drug bridging strategy and quality by design

Journal of Applied Pharmaceutical Research
Background: This study aimed to develop a stable, clinically suitable topical mechlorethamine formulation using Quality by Design (QbD) principles to address chemical instability and cytotoxicity.
Hemil Shah, Prachi Pandey, Priyal Patel   +2 more
doaj   +1 more source

MALDI-TOF-MS spectrum of the mechlorethamine-crosslinked DNA duplex.

, 2013
MALDI-TOF-MS spectrum of the mechlorethamine-crosslinked DNA duplex.
Pornchai Rojsitthisak (350320), Nutthapon Jongaroonngamsang (350321), Ian S. Haworth (13517), Rebecca M. Romero (350322)   +3 more
core   +1 more source

Structures of possible mechlorethamine crosslinks at a cytosine-cytosine mismatch pair.

, 2013
A: A mechlorethamine crosslink through O2 of cytosine. B: A mechlorethamine crosslink through N3 of cytosine. C: A mechlorethamine crosslink through N4 of cytosine.
Pornchai Rojsitthisak (350320), Nutthapon Jongaroonngamsang (350321), Ian S. Haworth (13517), Rebecca M. Romero (350322)   +3 more
core   +1 more source