Results 41 to 50 of about 2,545 (184)
Long‐Term Quality of Life in 1777 Persons With Hodgkin Lymphoma and 6166 Matched Comparators
ABSTRACT Survival has improved substantially for patients with Hodgkin lymphoma (HL), but long‐term quality of life (QoL) remains incompletely understood. This was a Danish, nationwide, cross‐sectional study of QoL among persons with a diagnosis of HL matched 1:10 to general population comparators.
Sissel Johanne Godtfredsen +13 more
wiley +1 more source
ABSTRACT Background and Purpose: Hodgkin lymphoma (HL) is an uncommon malignancy predominantly affecting young adults. Chemotherapy is the main treatment, with radiotherapy used selectively in early‐stage disease. This meta‐analysis evaluates the impact of adding radiotherapy to bulky disease sites in advanced‐stage HL patients who achieve complete ...
Ahmad Masoud +12 more
wiley +1 more source
HPLC-UV chromatograms of DNA and the mechlorethamine-crosslinked DNA duplex.
A: Top-strand DNA. B: Bottom-strand DNA. C: DNA duplex (denatured on the column). D: The mechlorethamine-crosslinked DNA duplex.
Pornchai Rojsitthisak (350320) +3 more
core +1 more source
The schematic illustrates that corneal injury imparted by a stromal incision or by toxic chemical exposure causes corneal Schwann cells (cSCs) and axons to degenerate rapidly, resulting in impaired mechanosensory function. We hypothesized that repair cSCs, which develop post injury, are an as‐yet‐untested cellular target for axonal regeneration.
Michael Li +6 more
wiley +1 more source
Melanogenesis From Topical Mechlorethamine And Analogues In Skin Of Hairless Mice And In Vitiligo
Progressive repigmentation occurred in vitiliginous skin of two patients topically treated with aqueous solutions of mechlorethamine. Hairless mice were found to provide what seems to be a satisfactory cutaneous system for evaluating potential ...
Yu, R J +3 more
core +1 more source
Caitlin Crimp,1 Ameya Gangal,2 Erica S Tarabadkar,3 Michi M Shinohara1,4 1Division of Dermatology, University of Washington, Seattle, WA, USA; 2School of Medicine, Emory University, Atlanta, GA, USA; 3Department of Dermatology, Emory University School of
Crimp C +3 more
doaj
HPLC has been applied to determine the stability of mechlorethamine hydrochloride (nitrogen mustard) formulated as an ointment in white soft paraffin (10 mg drug, 50 g paraffin and 1 mL acetone). A new solubilization technique is described for extraction
J F Smyth +3 more
core +1 more source
Nitrogen Mustard (Mechlorethamine) and UVB Photocarcinogenesis: A Dose Response Effect
The effects of UVB energy and nitrogen mustard (mechlorethamine, HN2) on tumor formation in the hairless mouse skin was examined. Twice weekly applications of HN2 produced tumors in 34% of the mice.
Epstein, John H., John H. Epstein
core +1 more source
Oncology drug repurposing as a blueprint for Alzheimer's therapy
Abstract Alzheimer's disease (AD) imposes substantial personal, social, and economic burdens, yet current therapies provide only modest slowing of clinical decline. Recent approvals of amyloid‐targeting antibodies confirm target engagement but also expose the limitations of single‐target strategies in a disease shaped by interacting processes ...
Viswanath Das, Marián Hajdúch
wiley +1 more source
BACKGROUND In the last two decades, it has become evident that secondary leukemias after Hodgkin's disease (HD) are mainly caused by the treatment with alkylating agents, especially mechlorethamine. Since 1978, the German-Austrian trials for childhood HD
M Riepenhausen +6 more
core +1 more source

