Results 21 to 30 of about 2,545 (184)
Frontiers in Immunology, 2023 Mycoses fungoides (MF) and Sézary syndrome (SS) are cutaneous T-cell lymphomas that are often challenging to manage given the absence of reliably curative therapies, at times high symptom burden with significant detriment to quality of life, and need for
Robert Stuver, Shamir Geller
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Current Research in Toxicology, 2021 The purpose of the present study was to investigate the vesicant countermeasure effects of hydrocortisone (HC) and ebselen (EB-1), administered as monotherapy or as a combination treatment.
Hemanta C Rao Tumu +2 more
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Chlormethine Gel is Efficient and Safe in Mycosis Fungoides Skin Lesions
Acta Dermato-Venereologica, 2022 Chlormethine is a bifunctional cytotoxic alkylating agent that binds to DNA, resulting in cell death (apoptosis). Chlormethine (also known as mechlorethamine) gel (CL gel) was approved in the European Union in 2017 and was first used in 2019.
Marios Koumourtzis +3 more
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, 2022 INTRODUCTION: Treatment of early-stage mycosis fungoides (MF) requires safe, skin-directed therapies. Medication side effects can lead to underutilization of effective therapies.
Alexander-Savino, Carolina V +4 more
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NAD+ Acts as a Protective Factor in Cellular Stress Response to DNA Alkylating Agents
Cells, 2023 Sulfur mustard (SM) and its derivatives are potent genotoxic agents, which have been shown to trigger the activation of poly (ADP-ribose) polymerases (PARPs) and the depletion of their substrate, nicotinamide adenine dinucleotide (NAD+).
Joanna Ruszkiewicz +10 more
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Cells, 2023 Caenorhabditis elegans (C. elegans) is gaining recognition and importance as an organismic model for toxicity testing in line with the 3Rs principle (replace, reduce, refine). In this study, we explored the use of C.
Joanna Ruszkiewicz +4 more
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Mechlorethamine-Induced DNA–Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells
, 2016 Antitumor nitrogen mustards, such as bis(2-chloroethyl)methylamine (mechlorethamine), are useful chemotherapeutic agents with a long history of clinical application. The antitumor effects of nitrogen mustards are attributed to their ability to induce DNA–
Natalia Y. Tretyakova (1330866) +6 more
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Animal Models and Experimental Medicine, 2023 Background Sulfur mustard (SM) is a chemical warfare vesicant that severely injures exposed eyes, lungs, and skin. Mechlorethamine hydrochloride (NM) is widely used as an SM surrogate.
Tomas L. Roldan +4 more
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