Utility of T-cell immunosequencing in distinguishing mycosis fungoides progression from treatment related cutaneous adverse events [PDF]
Frontiers in Medicine, 2023 Cutaneous adverse events of both topical and systemic drugs in patients with mycosis fungoides (MF) present a diagnostic challenge as it is often difficult to distinguish drug associated rash from disease progression in the skin.
Safiyyah Bhatti +8 more
doaj +2 more sources
HPLC-UV, MALDI-TOF-MS and ESI-MS/MS analysis of the mechlorethamine DNA crosslink at a cytosine-cytosine mismatch pair. [PDF]
PLoS ONE, 2011 Mechlorethamine [ClCH(2)CH(2)N(CH(3))CH(2)CH(2)Cl], a nitrogen mustard alkylating agent, has been proven to form a DNA interstrand crosslink at a cytosine-cytosine (C-C) mismatch pair using gel electrophoresis.
Pornchai Rojsitthisak +3 more
doaj +2 more sources
Phase 1 Dose Escalation of Single-Agent Mechlorethamine in Dogs With Lymphoma. [PDF]
Vet Comp OncolABSTRACT Mechlorethamine is commonly prescribed to dogs at 3 mg/m2. The minimal toxicity observed indicates that higher doses of mechlorethamine are likely tolerable. The primary objective of this study was to determine the maximally tolerated dose (MTD) of mechlorethamine in dogs with lymphoma.
Chadsey LE, Hess PR, Intile JL.
europepmc +2 more sources
A practical and safer model of nitrogen mustard injury in cornea. [PDF]
PLoS ONEPurposeSulfur mustard (SM) is an alkylating agent used in warfare and terrorism that inflicts devastating ocular injuries. Although the clinical symptoms are well described, the underlying mechanisms are not fully understood, hindering the development of
Ana M Sandoval-Castellanos +6 more
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DNA-Peptide Crosslinks Placed at Codon 249 of the p53 Tumor Suppressor Gene Induce G to A Transitions in Human Cells. [PDF]
ChembiochemDNA‐peptide cross‐links (DpCs) are ubiquitous DNA lesions that form when cellular proteins become covalently trapped on DNA strands and are processed by proteases. DpCs are hypothesized to play a role in antitumor activity of chemotherapeutic drugs and to contribute to aging.
Yawson P +4 more
europepmc +2 more sources
Skin-Directed Therapies in Mycosis Fungoides: An Update [PDF]
Dermatology and TherapyMycosis fungoides (MF) is the most common subtype of cutaneous T cell lymphoma (CTCL), characterized by monoclonal proliferation of malignant T cells primarily involving the skin.
Maciej Tota +7 more
doaj +2 more sources
Results from a Pilot Study of HyBryte™ (Topical Synthetic Hypericin) Versus Valchlor® (Mechlorethamine) in the Treatment of CTCL [PDF]
Oncology and TherapyIntroduction Mycosis fungoides (MF) is the most common type of primary cutaneous T-cell lymphoma (CTCL), a malignant and chronic skin disease. Early-stage MF has a generally favorable prognosis, but effective and well-tolerated skin-directed therapies ...
Brian Poligone +6 more
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In Vivo Evidence of Melatonin’s Protective Role in Alkylating-Agent-Induced Pulmonary Toxicity: A Systematic Review [PDF]
AntioxidantsAlkylating agents, historically employed as chemical warfare agents and currently used as chemotherapeutic drugs, are known to induce significant pulmonary toxicity. Current clinical interventions often fail to fully prevent or reverse these pathological
Emma Sola +4 more
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Mechanistic Insights and Pharmacological Approaches for Nitrogen and Sulfur Mustards and Their Implications as Therapeutic Agents. [PDF]
J Appl ToxicolABSTRACT Nitrogen and sulfur mustards, often acting as vesicants, have significant consequences for public health. Skin is a common site for exposure to these vesicants that can result in considerable morbidity and mortality. Given that the treatment options are limited, new insights into the mechanisms for the toxicity of these vesicants that can be ...
Owens M +3 more
europepmc +2 more sources
Mediterranean Journal of Hematology and Infectious Diseases, 2012 Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related ...
Ercole Brusamolino +2 more
doaj +4 more sources