Results 11 to 20 of about 3,833 (193)
Phase 1 Dose Escalation of Single-Agent Mechlorethamine in Dogs With Lymphoma. [PDF]
Vet Comp OncolABSTRACT Mechlorethamine is commonly prescribed to dogs at 3 mg/m2. The minimal toxicity observed indicates that higher doses of mechlorethamine are likely tolerable. The primary objective of this study was to determine the maximally tolerated dose (MTD) of mechlorethamine in dogs with lymphoma.
Chadsey LE, Hess PR, Intile JL.
europepmc +2 more sources
Mechanistic Insights and Pharmacological Approaches for Nitrogen and Sulfur Mustards and Their Implications as Therapeutic Agents. [PDF]
J Appl ToxicolABSTRACT Nitrogen and sulfur mustards, often acting as vesicants, have significant consequences for public health. Skin is a common site for exposure to these vesicants that can result in considerable morbidity and mortality. Given that the treatment options are limited, new insights into the mechanisms for the toxicity of these vesicants that can be ...
Owens M +3 more
europepmc +2 more sources
Management of Mycosis Fungoides With Chlormethine Hydrochloride Gel in Combination With Systemic Therapies: A Case Series. [PDF]
Case Rep Dermatol MedBackground Mycosis fungoides (MF) is a subtype of T‐cell lymphoma that is characterised by the infiltration of malignant T cells into the skin. Treatment approaches usually include skin‐directed therapies for early‐stage disease and, additionally, systemic therapies for advanced stages.
Dobos G +6 more
europepmc +2 more sources
Current Research in Toxicology, 2021 The purpose of the present study was to investigate the vesicant countermeasure effects of hydrocortisone (HC) and ebselen (EB-1), administered as monotherapy or as a combination treatment.
Hemanta C Rao Tumu +2 more
doaj +1 more source
Mediterranean Journal of Hematology and Infectious Diseases, 2012 Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related ...
Ercole Brusamolino +2 more
doaj +3 more sources
Chlormethine Gel is Efficient and Safe in Mycosis Fungoides Skin Lesions
Acta Dermato-Venereologica, 2022 Chlormethine is a bifunctional cytotoxic alkylating agent that binds to DNA, resulting in cell death (apoptosis). Chlormethine (also known as mechlorethamine) gel (CL gel) was approved in the European Union in 2017 and was first used in 2019.
Marios Koumourtzis +3 more
doaj +1 more source
Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs [PDF]
, 2017 Quinone-based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs.
Alsford, Sam +7 more
core +4 more sources
NAD+ Acts as a Protective Factor in Cellular Stress Response to DNA Alkylating Agents
Cells, 2023 Sulfur mustard (SM) and its derivatives are potent genotoxic agents, which have been shown to trigger the activation of poly (ADP-ribose) polymerases (PARPs) and the depletion of their substrate, nicotinamide adenine dinucleotide (NAD+).
Joanna Ruszkiewicz +10 more
doaj +1 more source
Cells, 2023 Caenorhabditis elegans (C. elegans) is gaining recognition and importance as an organismic model for toxicity testing in line with the 3Rs principle (replace, reduce, refine). In this study, we explored the use of C.
Joanna Ruszkiewicz +4 more
doaj +1 more source
Synthesis of structurally diverse major groove DNA interstrand crosslinks using three different aldehyde precursors [PDF]
, 2014 DNA interstrand crosslinks (ICLs) are extremely cytotoxic lesions that block essential cellular processes, such as replication and transcription. Crosslinking agents are widely used in cancer chemotherapy and form an array of structurally diverse ICLs ...
A. Guainazzi +26 more
core +1 more source