Results 11 to 20 of about 2,200 (151)

Phase 1 Dose Escalation of Single-Agent Mechlorethamine in Dogs With Lymphoma. [PDF]

Vet Comp Oncol
ABSTRACT Mechlorethamine is commonly prescribed to dogs at 3 mg/m2. The minimal toxicity observed indicates that higher doses of mechlorethamine are likely tolerable. The primary objective of this study was to determine the maximally tolerated dose (MTD) of mechlorethamine in dogs with lymphoma.
Chadsey LE, Hess PR, Intile JL.
europepmc   +2 more sources

Mechanistic Insights and Pharmacological Approaches for Nitrogen and Sulfur Mustards and Their Implications as Therapeutic Agents. [PDF]

J Appl Toxicol
ABSTRACT Nitrogen and sulfur mustards, often acting as vesicants, have significant consequences for public health. Skin is a common site for exposure to these vesicants that can result in considerable morbidity and mortality. Given that the treatment options are limited, new insights into the mechanisms for the toxicity of these vesicants that can be ...
Owens M, Thyagarajan A, Travers JB, Sahu RP.   +3 more
europepmc   +2 more sources

Choosing between Nivo-AVD and BrECADD: Hodgkin lymphoma's new era. [PDF]

Br J Haematol
British Journal of Haematology, Volume 208, Issue 6, Page 2239-2242, June 2026.
Cliff ERS, McKeague S, Dickinson MJ.
europepmc   +2 more sources

Management of Mycosis Fungoides With Chlormethine Hydrochloride Gel in Combination With Systemic Therapies: A Case Series. [PDF]

Case Rep Dermatol Med
Background Mycosis fungoides (MF) is a subtype of T‐cell lymphoma that is characterised by the infiltration of malignant T cells into the skin. Treatment approaches usually include skin‐directed therapies for early‐stage disease and, additionally, systemic therapies for advanced stages.
Dobos G, Jonak C, Klespe KC, Wobser M, de Masson A, Hoffmann J, Mitteldorf C.   +6 more
europepmc   +2 more sources

Combination of ebselen and hydrocortisone substantially reduces nitrogen mustard-induced cutaneous injury

Current Research in Toxicology, 2021
The purpose of the present study was to investigate the vesicant countermeasure effects of hydrocortisone (HC) and ebselen (EB-1), administered as monotherapy or as a combination treatment.
Hemanta C Rao Tumu, Benedette J. Cuffari, Blase Billack   +2 more
doaj   +1 more source

Chlormethine Gel is Efficient and Safe in Mycosis Fungoides Skin Lesions

Acta Dermato-Venereologica, 2022
Chlormethine is a bifunctional cytotoxic alkylating agent that binds to DNA, resulting in cell death (apoptosis). Chlormethine (also known as mechlorethamine) gel (CL gel) was approved in the European Union in 2017 and was first used in 2019.
Marios Koumourtzis, Kyriaki Lampadaki, Maria Dalamaga, Evangelia Papadavid   +3 more
doaj   +1 more source

NAD⁺ Acts as a Protective Factor in Cellular Stress Response to DNA Alkylating Agents

Cells, 2023
Sulfur mustard (SM) and its derivatives are potent genotoxic agents, which have been shown to trigger the activation of poly (ADP-ribose) polymerases (PARPs) and the depletion of their substrate, nicotinamide adenine dinucleotide (NAD+).
Joanna Ruszkiewicz, Ylea Papatheodorou, Nathalie Jäck, Jasmin Melzig, Franziska Eble, Annika Pirker, Marius Thomann, Andreas Haberer, Simone Rothmiller, Alexander Bürkle, Aswin Mangerich   +10 more
doaj   +1 more source

Depilatory double‐disc mouse model for evaluation of vesicant dermal injury pharmacotherapy countermeasures

Animal Models and Experimental Medicine, 2023
Background Sulfur mustard (SM) is a chemical warfare vesicant that severely injures exposed eyes, lungs, and skin. Mechlorethamine hydrochloride (NM) is widely used as an SM surrogate.
Tomas L. Roldan, Shike Li, Jeffrey D. Laskin, Dayuan Gao, Patrick J. Sinko   +4 more
doaj   +1 more source

Life-Cycle-Dependent Toxicities of Mono- and Bifunctional Alkylating Agents in the 3R-Compliant Model Organism C. elegans

Cells, 2023
Caenorhabditis elegans (C. elegans) is gaining recognition and importance as an organismic model for toxicity testing in line with the 3Rs principle (replace, reduce, refine). In this study, we explored the use of C.
Joanna Ruszkiewicz, Lisa Endig, Ebru Güver, Alexander Bürkle, Aswin Mangerich   +4 more
doaj   +1 more source

Development and optimization of a mechlorethamine topical formulation utilizing a model drug bridging strategy and quality by design

Journal of Applied Pharmaceutical Research
Background: This study aimed to develop a stable, clinically suitable topical mechlorethamine formulation using Quality by Design (QbD) principles to address chemical instability and cytotoxicity.
Hemil Shah, Prachi Pandey, Priyal Patel   +2 more
doaj   +1 more source