Results 31 to 40 of about 2,545 (184)

Topical Mechlorethamine for the Treatment of Psoriasis: A Report of Two Cases and Literature Review

, 2022
INTRODUCTION: Psoriasis is a common inflammatory skin disease that significantly impacts patients’ psychosocial wellbeing. Despite increasingly effective treatment options, the recurrence of plaques after discontinuation of therapy in many patients ...
Schreidah, Celine M., Kwinta, Bradley D., Ferris, Laura K., Fahmy, Lauren M., Geskin, Larisa J.   +4 more
core   +1 more source

Development and optimization of a mechlorethamine topical formulation utilizing a model drug bridging strategy and quality by design

Journal of Applied Pharmaceutical Research
Background: This study aimed to develop a stable, clinically suitable topical mechlorethamine formulation using Quality by Design (QbD) principles to address chemical instability and cytotoxicity.
Hemil Shah, Prachi Pandey, Priyal Patel   +2 more
doaj   +1 more source

MALDI-TOF-MS spectrum of the mechlorethamine-crosslinked DNA duplex.

, 2013
MALDI-TOF-MS spectrum of the mechlorethamine-crosslinked DNA duplex.
Pornchai Rojsitthisak (350320), Nutthapon Jongaroonngamsang (350321), Ian S. Haworth (13517), Rebecca M. Romero (350322)   +3 more
core   +1 more source

Structures of possible mechlorethamine crosslinks at a cytosine-cytosine mismatch pair.

, 2013
A: A mechlorethamine crosslink through O2 of cytosine. B: A mechlorethamine crosslink through N3 of cytosine. C: A mechlorethamine crosslink through N4 of cytosine.
Pornchai Rojsitthisak (350320), Nutthapon Jongaroonngamsang (350321), Ian S. Haworth (13517), Rebecca M. Romero (350322)   +3 more
core   +1 more source

The Management of Classical Hodgkin's Lymphoma: Past, Present, and Future

Advances in Hematology, 2011
The management of classical Hodgkin's lymphoma (CHL) is a success story of modern multi-agent haemato-oncology. Prior to the middle of the twentieth century CHL was fatal in the majority of cases.
S. E. Richardson, C. McNamara
doaj   +1 more source

Mediastinal Choriocarcinoma Masquerading as Relapsed Hodgkin Lymphoma

Case Reports in Oncology, 2011
Primary mediastinal choriocarcinoma is a rare extragonadal germ cell malignancy. We describe the first case of a patient who developed mediastinal choriocarcinoma after treatment for Hodgkin lymphoma (HL).
Selay Lam, Kamilia Rizkalla, Cyrus C. Hsia   +2 more
doaj   +1 more source

Topical Mechlorethamine Restores Autoimmune-Arrested Follicular Activity in Mice with an Alopecia Areata-Like Disease by Targeting Infiltrated Lymphocytes

, 2003
Alopecia areata is an autoimmune disease targeted at hair follicles with infiltrated T lymphocytes probably playing an important role in the pathogenesis. It was reported in 1985 that mechlorethamine was effective on alopecia areata patients.
Shapiro, Jerry, Bernardo, O, Chung, Stephen, Lui, H, Chen, Yongliang, Tang, Liren, Chen, Y, Chung, S, Lui, Harvey, Bernardo, Olga, Cao, Liping, Sundberg, John P., Cao, L, Sundberg, J P, Shapiro, J, Tang, L   +15 more
core   +1 more source

Targeted Drug Delivery of Anticancer Agents Using C₅N₂ Substrate: Insights from Density Functional Theory

Chemistry
Cancer has a threatening impact on human health, and it is one of the primary causes of fatalities worldwide. Different conventional treatments have been employed to treat cancer, but their non-specific nature reduces their therapeutic efficacy.
Syeda Huda Mehdi Zaidi, Muhammad Ajmal, Muhammad Ali Hashmi, Ahmed Lakhani   +3 more
doaj   +1 more source

Topical Mechlorethamine Chemotherapy

International Journal of Dermatology, 1984
Eric C. Vonderheid
openaire   +3 more sources

Brentuximab Vedotin‐Induced Rash Sparing CD30‐Positive Mycosis Fungoides Lesions

JEADV Clinical Practice, EarlyView.
ABSTRACT Brentuximab vedotin (BV) is an effective treatment for CD30‐positive lymphomas, including mycosis fungoides (MF). However, its use can be associated with various cutaneous adverse effects, including rashes. This case describes a 60‐year‐old male with stage IIB MF who developed a drug‐induced erythematous rash after three infusions of BV ...
Isabel Hariri, Alexander H. Enk, Jessica C. Hassel   +2 more
wiley   +1 more source