Results 61 to 70 of about 2,699 (183)

DKK1 Targeting in Corneal Schwann Cells Rescues Axonal Regeneration and Mechanosensory Function After Corneal Injury

open access: yesJournal of Neuroscience Research, Volume 104, Issue 6, June 2026.
The schematic illustrates that corneal injury imparted by a stromal incision or by toxic chemical exposure causes corneal Schwann cells (cSCs) and axons to degenerate rapidly, resulting in impaired mechanosensory function. We hypothesized that repair cSCs, which develop post injury, are an as‐yet‐untested cellular target for axonal regeneration.
Michael Li   +6 more
wiley   +1 more source

The Long Term Stability of Mechlorethamine Hydrochloride (Nitrogen Mustard) Ointment Measured by HPLC

open access: yes, 1993
HPLC has been applied to determine the stability of mechlorethamine hydrochloride (nitrogen mustard) formulated as an ointment in white soft paraffin (10 mg drug, 50 g paraffin and 1 mL acetone). A new solubilization technique is described for extraction
J F Smyth   +3 more
core   +1 more source

Mechlorethamine Hydrochloride Gel in the Treatment of Mycosis Fungoides–Type Cutaneous T-Cell Lymphoma (MF-CTCL): A Focus on Patient Selection and Special Considerations

open access: yesCancer Management and Research, 2022
Caitlin Crimp,1 Ameya Gangal,2 Erica S Tarabadkar,3 Michi M Shinohara1,4 1Division of Dermatology, University of Washington, Seattle, WA, USA; 2School of Medicine, Emory University, Atlanta, GA, USA; 3Department of Dermatology, Emory University School of
Crimp C   +3 more
doaj  

Low risk of secondary leukemias after chemotherapy without mechlorethamine in childhood Hodgkin's disease. German-Austrian Pediatric Hodgkin's Disease Group.

open access: yes, 1997
BACKGROUND In the last two decades, it has become evident that secondary leukemias after Hodgkin's disease (HD) are mainly caused by the treatment with alkylating agents, especially mechlorethamine. Since 1978, the German-Austrian trials for childhood HD
M Riepenhausen   +6 more
core   +1 more source

Management of mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL): focus on chlormethine gel

open access: yesCancer Management and Research, 2019
Daphné Denis,1 Nathalie Beneton,1 Kamel Laribi,2 Hervé Maillard1 1Dermatology Department, Centre Hospitalier Le Mans, Le Mans, France; 2Haematology Department, Centre Hospitalier Le Mans, Le Mans, France Abstract: Mycosis fungoides (MF) is ...
Denis D, Beneton N, Laribi K, Maillard H
doaj  

Age‐Specific Gonadotoxic Alkylating‐Agent Exposure in Pediatric and Reproductive‐Age Females: A Claims‐Based Study Using Cyclophosphamide Equivalent Dose

open access: yesReproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Purpose To describe age‐specific patterns of gonadotoxic alkylating‐agent exposure and evaluate how the cyclophosphamide equivalent dose (CED) framework captures real‐world exposure relevant to fertility preservation in females aged 0–43 years. Methods This descriptive study used a Japanese claims database.
Kentaro Taniguchi   +7 more
wiley   +1 more source

Mycosis fungoides in a lung transplant recipient with advanced ciclosporin nephropathy: management with mechlorethamine and subsequent renal transplantation.

open access: yes, 2008
Posttransplant cutaneous T cell lymphomas are rare and have been reported to have a poor prognosis. We report the case of a follicular mycosis fungoides in a lung transplant recipient who was successfully treated with topical mechlorethamine, prior to ...
Venetz, J.P.   +5 more
core   +1 more source

Oncology drug repurposing as a blueprint for Alzheimer's therapy

open access: yesAlzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract Alzheimer's disease (AD) imposes substantial personal, social, and economic burdens, yet current therapies provide only modest slowing of clinical decline. Recent approvals of amyloid‐targeting antibodies confirm target engagement but also expose the limitations of single‐target strategies in a disease shaped by interacting processes ...
Viswanath Das, Marián Hajdúch
wiley   +1 more source

Chronic Ulcer on the Vulva

open access: yes
JEADV Clinical Practice, Volume 5, Issue 3, Page 1010-1012, September 2026.
Farhanaz Panjshiri   +2 more
wiley   +1 more source

Exposure the Hazardous Potential of Quinalphos: An In‐Depth Analysis for Environmental and Biological Effects on Human Health

open access: yesIET Systems Biology, Volume 20, Issue 1, January/December 2026.
This study elucidates pesticide docking onto proteins encoded by differentially expressed genes, revealing interaction networks involving chemicals, genes, proteins, drugs and diseases. It highlights structural insights, regulatory pathways and potential therapeutic or environmental implications, providing a comprehensive understanding of the ...
Jyoti Kant Choudhari   +4 more
wiley   +1 more source

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