Melatonin as Modulator for Sulfur and Nitrogen Mustard-Induced Inflammation, Oxidative Stress and DNA Damage: Molecular Therapeutics [PDF]
Antioxidants, 2023 Sulfur and nitrogen mustards, bis(2-chloroethyl)sulfide and tertiary bis(2-chloroethyl) amines, respectively, are vesicant warfare agents with alkylating activity.
Eva Ramos +10 more
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Targeting TRPV1-mediated autophagy attenuates nitrogen mustard-induced dermal toxicity. [PDF]
Signal Transduct Target Ther, 2021 Nitrogen mustard (NM) causes severe vesicating skin injury, which lacks effective targeted therapies. The major limitation is that the specific mechanism of NM-induced skin injury is not well understood.
Chen M +10 more
europepmc +2 more sources
Therapeutic Potential of Nitrogen Mustard Based Hybrid Molecules
Frontiers in Pharmacology, 2018 As medicine advances, cancer is still among one of the major health problems, posing significant threats to human health. New anticancer agents features with novel scaffolds and/or unique mechanisms of action are highly desirable for the treatment of ...
Yiming Chen +3 more
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Frontiers in Plant Science, 2020 Strategic use of nitrogen (N) may improve N use efficiency, but there is limited information on the influence of N supply at crucial growth stages on N accumulation, water use, and water use efficiency of canola and mustard. In this study, we hypothesize
Amritbir Riar +3 more
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3D- and 2D-QSAR models’ study and molecular docking of novel nitrogen-mustard compounds for osteosarcoma [PDF]
Frontiers in Molecular Biosciences, 2023 Background: The dipeptide-alkylated nitrogen-mustard compound is a new kind of nitrogen-mustard derivative with a strong anti-tumor activity, which can be used as a potential anti-osteosarcoma chemotherapy drug.Objective: 2D- and 3D-QSAR (structure ...
Wenkun Zhuo +4 more
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Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η. [PDF]
Biochem J, 2020 Nitrogen mustards are among the first modern anticancer chemotherapeutics that are still widely used as non-specific anticancer alkylating agents. While the mechanism of action of mustard drugs involves the generation of DNA interstrand cross-links, the ...
Jung H, Rayala NK, Lee S.
europepmc +2 more sources
Study on the Reaction Kinetics of Sulfur Mustard, Nitrogen Mustard and Their Chosen Analogues with Sodium Ethoxide [PDF]
MoleculesThe course and kinetics of the reactions of sulfur mustard, nitrogen mustard and their selected analogues with sodium ethoxide were studied using a gas chromatograph coupled with a mass spectrometer.
Klaudia Kozon +3 more
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Eruptive Cherry Angiomas After Nitrogen Mustard Treatment for Vitiligo [PDF]
Clinical, Cosmetic and Investigational DermatologyHuiying Wang,1 Ruzhi Zhang2 1Department of Dermatology, The Third Affiliated Hospital of Soochow University, Changzhou, People’s Republic of China; 2Department of Dermatology, The Second Affiliated Hospital of Wannan Medical College, Wuhu, People’s ...
Wang H, Zhang R
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Method for the synthesis of flavonoid nitrogen mustard derivatives [PDF]
MethodsX, 2020 We have prepared a kind of new type of flavonoid nitrogen mustard derivatives with broad-spectrum antitumor activity, which have not been reported in the literature.
Jinglei Song +3 more
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Senescence and Stress Signaling Pathways in Corneal Cells After Nitrogen Mustard Injury [PDF]
CellsMustard gas keratopathy (MGK), a complication of exposure to sulfur mustard, is a blinding ocular surface disease involving key cellular pathways, including apoptosis, oxidative stress, and inflammation.
Khandaker N. Anwar +13 more
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