Chlormethine gel in combination with other therapies for treatment of mycosis fungoides: a review with patient cases [PDF]
Frontiers in Medicine, 2023 Topical chlormethine gel has been approved as monotherapy for treatment of adult patients with mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma. In clinical practice, chlormethine gel is often combined with other skin-directed or
Marco Ardigò +6 more
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Expert opinions and clinical experiences with chlormethine gel as maintenance treatment for patients with mycosis fungoides [PDF]
Frontiers in Medicine, 2023 Maintenance treatment can be recommended for patients with mycosis fungoides (MF) whose disease responds to primary treatment. While positive outcomes have been observed in small studies with maintenance therapy, there is a lack of practical guidelines ...
Larisa Geskin +10 more
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Chlormethine Gel is Efficient and Safe in Mycosis Fungoides Skin Lesions [PDF]
Acta Dermato-Venereologica, 2022 Chlormethine is a bifunctional cytotoxic alkylating agent that binds to DNA, resulting in cell death (apoptosis). Chlormethine (also known as mechlorethamine) gel (CL gel) was approved in the European Union in 2017 and was first used in 2019.
Marios Koumourtzis +3 more
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Effectiveness and tolerability of chlormethine gel for the management of mycosis fungoides: a multicenter real-life evaluation [PDF]
Frontiers in Oncology, 2023 BackgroundTopical chlormethine (CL) is recommended as a first-line treatment for early-stage mycosis fungoides (MF) and in 2017, the European Medicines Agency approved the CL gel formulation to treat adult patients.
Silvia Alberti-Violetti +10 more
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Chlormethine gel effectiveness as second-line treatment in mycosis fungoides: a single-centre retrospective study [PDF]
Discover OncologyBackground Chlormethine gel is a promising treatment for early-stage mycosis fungoides (MF) with strong efficacy and manageable side effects. This study evaluates its effectiveness as a second-line treatment in patients unresponsive to prior skin ...
Corrado Zengarini +9 more
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Case report: Canadian consensus on chlormethine gel use in mycosis fungoides-CTCL: literature review and real-world experience [PDF]
Frontiers in MedicineMycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL), representing the majority of all lymphomas arising in the skin. The disease treatment focuses on managing symptoms and preventing disease evolution.
Ivan V. Litvinov +9 more
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Chlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to Clinicians [PDF]
Dermatology and TherapyBackground Mycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma. While multiple guidelines provide treatment recommendations, there are currently no clear treatment algorithms for MF.
Larisa Geskin +7 more
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Prior Bexarotene or Phototherapy Does Not Affect Response to Chlormethine Gel: Post Hoc Analysis of a Pivotal Trial [PDF]
Acta Dermato-Venereologica, 2023 is missing (Short communication)
Chalid Assaf +4 more
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A Little Experience Goes a Long Way: Chlormethine/Mechlorethamine Treatment Duration as a Function of Clinician-Level Patient Volume for Mycosis Fungoides Cutaneous T-Cell Lymphoma (MF-CTCL)—A Retrospective Cohort Study [PDF]
Frontiers in Medicine, 2021 Topical chlormethine yields high response rates in mycosis fungoides cutaneous T-cell lymphoma with early discontinuation often attributed to skin reactions.
Christiane Querfeld +5 more
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Computational exploration of anticancer drug adsorption on a porous organic nanocage: Insights from density functional theory for targeted nanocarrier design [PDF]
Scientific ReportsDesigning efficient nanocarriers for targeted cancer therapy requires a deep understanding of drug–nanomaterial interactions at the molecular level. In this study, the adsorption behavior of four clinically relevant anticancer drugs, 6-mercaptopurine (6 ...
Afrasim Moin +10 more
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