Results 181 to 190 of about 26,323 (234)
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The biotransformation of nitroglycerin
Biochemical Pharmacology, 1965Abstract The transformation of nitroglycerin (NG) was accomplished by the formation of 1,2- and 1,3-dinitroglycerin. The dinitrates were resistant to further degradation and appeared as the urinary metabolites after the administration of NG. The dinitroglycerins were less active coronary vasodilators and blood pressure depressants than NG.
John C. Krantz, Philip Needleman
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Nitroprusside or Nitroglycerin
Annals of Internal Medicine, 1981Excerpt To the editor: Dr. Tillisch (1) proposes nitroprusside as the agent of choice for impedance reduction in the setting of septic shock with depressed cardiac output and substantially elevated...
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Herzwirkung des Nitroglycerins
Pfl�gers Archiv European Journal of Physiology, 1970Intravenose Nitroglycerininfusionen mit Stabilisierung des arteriellen Blutdruckes und intracoronare Infusionen gehen bei konstantem Aortendruck und unverandertem enddiastolischen Fullungsdruck des linken Ventrikels mit einer Steigerung der maximalen Druckanstiegsgeschwindigkeit im linken Ventrikel einher.
U. Drechsel +3 more
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Possible involvement of nitroglycerin converting step in nitroglycerin tolerance
Life Sciences, 1999Nitroglycerin (GTN) produces a dilation of vascular smooth muscle by releasing NO through a putative GTN-converting step. However, the response to GTN is markedly attenuated after prolonged or repeated exposure, resulting in tolerance. We investigated the mechanisms of GTN tolerance, employing exogenous and endogenous NO in rat aorta.
Ikunobu Muramatsu +4 more
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Pharmacokinetics of Nitroglycerin in Rats
Journal of Pharmaceutical Sciences, 1978The plasma nitroglycerin levels obtained after intracardial (0.7 mg/kg), oral (7 mg/kg), and topical (7--14 mg/kg) doses of nitroglycerin in rats are reported. Nitroglycerin followed essentially one-compartment kinetics after intracardial administration, showing a mean half-life of about 4 min and a mean apparent volume of distribution of about 3 ...
Peter S.K. Yap, Ho-Leung Fung
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Pharmaceutical Considerations of Nitroglycerin
Drug Intelligence & Clinical Pharmacy, 1983During the past few years, there have been rapid changes in the pharmaceutical uses of nitroglycerin. New dosage forms and new delivery systems have become available, which have resulted in potential confusion to all concerned with the proper use of these systems. The goal of this review is to prevent confusion and to bring all the relevant information
Anton H. Amann +2 more
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Nitroglycerin for Angina Pectoris
JAMA, 1978To the Editor.— As a physician responsible for the long-term care of patients with coronary disease, I welcomed the recent comments of Oglesby Paul, MD, on the medical management of angina pectoris (238:1847, 1977). I agreed particularly with his skepticism about the value of long-acting nitrates.
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Bioactivation of Nitroglycerin by Ascorbate
Molecular Pharmacology, 2007Bioactivation of nitroglycerin (GTN) into an activator of soluble guanylate cyclase (sGC) is essential for the vasorelaxant effect of the drug. Besides several enzymes that catalyze GTN bioactivation, the reaction with cysteine is the sole nonenzymatic mechanism known so far. Here we show that a reaction with ascorbate results in GTN bioactivation.
Matteo Beretta +6 more
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