Results 151 to 160 of about 6,542 (200)
An unusually cold active nitroreductase for prodrug activations
Bioorganic and Medicinal Chemistry, 2012 A set of PCR primers based on the genome sequence were used to clone a gene encoding a hypothetical nitroreductases (named as Ssap-NtrB) from uropathogenic staphylococcus, Staphylococcus saprophyticus strain ATCC 15305, an oxygen insensitive flavoenzyme. Activity studies of the translation product revealed that the nitroreductase catalyses two electron
Ayhan Çelik
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Current Pharmaceutical Design, 2002
Nitroreductases that metabolise aromatic nitro groups to hydroxylamines are attractive as enzymes for GDEPT because of the very large electronic change that this metabolism generates, providing an efficient switch that can be exploited to generate potent cytotoxins. While nitroreductase enzymes are widespread, nearly all the work using these in GDEPT
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Nitroreductases that metabolise aromatic nitro groups to hydroxylamines are attractive as enzymes for GDEPT because of the very large electronic change that this metabolism generates, providing an efficient switch that can be exploited to generate potent cytotoxins. While nitroreductase enzymes are widespread, nearly all the work using these in GDEPT
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Nitroreductases in Prodrug Therapies
2020The aim of prodrug design is depended on optimizing the conditions to generate rational drug. The nitroreductases have been developed for prodrug strategies and nitro aromatic compounds are mostly used in the enzyme/prodrug combinations. Nitroreductase genes found most commonly in bacterial genomes and nitroreductase-like proteins also found rarely in ...
Tuğba Güngör +2 more
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Activity of an NADPH-Dependent Nitroreductase in Houseflies
Science, 1971A nitroreductase, reducing parathion to aminoparathion, was found in the soluble fraction that was obtained from abdomens of female houseflies. The reaction required reduced nicotinamide adenine dinucleotide phosphate (NADPH), but was not affected by the presence or absence of oxygen.
E P, Lichtenstein, T W, Fuhremann
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Identification of Aldehyde Oxidase as the Neonicotinoid Nitroreductase
Chemical Research in Toxicology, 2005Imidacloprid (IMI), the prototypical neonicotinoid insecticide, is used worldwide for crop protection and flea control on pets. It is both oxidatively metabolized by cytochrome P450 enzymes and reduced at the nitroguanidine moiety by a previously unidentified cytosolic "neonicotinoid nitroreductase", the subject of this investigation.
Ryan A, Dick +2 more
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Nitroreductase-activated nitric oxide (NO) prodrugs
Bioorganic & Medicinal Chemistry Letters, 2013Due to the involvement of nitric oxide (NO) in numerous and diverse physiological processes, site-directed delivery of therapeutic NO in order to minimize unwanted side-effects is necessary. O(2)-(4-Nitrobenzyl) diazeniumdiolates are designed as substrates for Escherichia coli nitroreductase (NTR), an enzyme that is frequently used to facilitate ...
Kavita, Sharma +2 more
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Antioxidants & Redox Signaling, 2001
Enterobacter cloacae strain 96-3 nitroreductase (NR) is a homodimeric flavoenzyme that catalyzes the pyridine nucleotide-dependent four-electron reduction of a variety of nitroaromatic compounds, including the explosives TNT (2,4,6-trinitrotoluene), RDX (1,3,5-trinitro-1,3,5-triazine), tetryl (2,4,6-trinitrophenyl-N-methylnitramine), and pentryl (2,4,6-
R L, Koder, O, Oyedele, A F, Miller
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Enterobacter cloacae strain 96-3 nitroreductase (NR) is a homodimeric flavoenzyme that catalyzes the pyridine nucleotide-dependent four-electron reduction of a variety of nitroaromatic compounds, including the explosives TNT (2,4,6-trinitrotoluene), RDX (1,3,5-trinitro-1,3,5-triazine), tetryl (2,4,6-trinitrophenyl-N-methylnitramine), and pentryl (2,4,6-
R L, Koder, O, Oyedele, A F, Miller
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The competitive inhibition of nitroreductase by some analogues of nitrofurantoin
Biochemical Pharmacology, 1968Abstract The ability of guinea pig liver microsomal and soluble preparations to reduce f-nitrobenzoic acid has been investigated. Furadantin and some related nitrofuran analogues have been showna to inhibit competitively the nitroreductase reduction of P-nitrobenzoic acid and the enzyme inhibitor characteristics are reported.
M T, Umar, M, Mitchard
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Type I nitroreductases of Escherichia coli
Canadian Journal of Microbiology, 1981Analysis of partially purified crude extract of Escherichia coli K12 by chromatography and gel electrophoresis has resulted in the separation of three distinct activities which catalyse the reduction of nitrofurazone (semicarbazone of 5-nitro-2-furaldehyde) in the presence of oxygen (type I nitroreductases).
D W, Bryant +3 more
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Nitroreductase-Activated Probes for Monitoring Hypoxia
ACS SensorsHypoxia, a hallmark of solid tumors, complicates cancer treatment by reducing the efficacy of radiotherapy and chemotherapy. To optimize strategies for hypoxia detection and targeted cancer therapy, this work explores the development of hypoxia-responsive fluorescent probes.
Eric Tran +7 more
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