Results 161 to 170 of about 5,837 (209)
Recent Advances in Fluorinated Colloidal Nanosystems for Biological Detection and Surface Coating. [PDF]
Polymers (Basel)Xu F, Cao X, Yan K.
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Pumping Iron for Tuberculosis Diagnostics. [PDF]
ACS Cent SciZigli A, Swarts BM.
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Nitroreductases in Prodrug Therapies
2020The aim of prodrug design is depended on optimizing the conditions to generate rational drug. The nitroreductases have been developed for prodrug strategies and nitro aromatic compounds are mostly used in the enzyme/prodrug combinations. Nitroreductase genes found most commonly in bacterial genomes and nitroreductase-like proteins also found rarely in ...
Tuğba Güngör +2 more
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Activity of an NADPH-Dependent Nitroreductase in Houseflies
Science, 1971A nitroreductase, reducing parathion to aminoparathion, was found in the soluble fraction that was obtained from abdomens of female houseflies. The reaction required reduced nicotinamide adenine dinucleotide phosphate (NADPH), but was not affected by the presence or absence of oxygen.
E P, Lichtenstein, T W, Fuhremann
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Current Pharmaceutical Design, 2002
Nitroreductases that metabolise aromatic nitro groups to hydroxylamines are attractive as enzymes for GDEPT because of the very large electronic change that this metabolism generates, providing an efficient switch that can be exploited to generate potent cytotoxins. While nitroreductase enzymes are widespread, nearly all the work using these in GDEPT
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Nitroreductases that metabolise aromatic nitro groups to hydroxylamines are attractive as enzymes for GDEPT because of the very large electronic change that this metabolism generates, providing an efficient switch that can be exploited to generate potent cytotoxins. While nitroreductase enzymes are widespread, nearly all the work using these in GDEPT
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Identification of Aldehyde Oxidase as the Neonicotinoid Nitroreductase
Chemical Research in Toxicology, 2005Imidacloprid (IMI), the prototypical neonicotinoid insecticide, is used worldwide for crop protection and flea control on pets. It is both oxidatively metabolized by cytochrome P450 enzymes and reduced at the nitroguanidine moiety by a previously unidentified cytosolic "neonicotinoid nitroreductase", the subject of this investigation.
Ryan A, Dick +2 more
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Nitroreductase-activated nitric oxide (NO) prodrugs
Bioorganic & Medicinal Chemistry Letters, 2013Due to the involvement of nitric oxide (NO) in numerous and diverse physiological processes, site-directed delivery of therapeutic NO in order to minimize unwanted side-effects is necessary. O(2)-(4-Nitrobenzyl) diazeniumdiolates are designed as substrates for Escherichia coli nitroreductase (NTR), an enzyme that is frequently used to facilitate ...
Kavita, Sharma +2 more
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Antioxidants & Redox Signaling, 2001
Enterobacter cloacae strain 96-3 nitroreductase (NR) is a homodimeric flavoenzyme that catalyzes the pyridine nucleotide-dependent four-electron reduction of a variety of nitroaromatic compounds, including the explosives TNT (2,4,6-trinitrotoluene), RDX (1,3,5-trinitro-1,3,5-triazine), tetryl (2,4,6-trinitrophenyl-N-methylnitramine), and pentryl (2,4,6-
R L, Koder, O, Oyedele, A F, Miller
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Enterobacter cloacae strain 96-3 nitroreductase (NR) is a homodimeric flavoenzyme that catalyzes the pyridine nucleotide-dependent four-electron reduction of a variety of nitroaromatic compounds, including the explosives TNT (2,4,6-trinitrotoluene), RDX (1,3,5-trinitro-1,3,5-triazine), tetryl (2,4,6-trinitrophenyl-N-methylnitramine), and pentryl (2,4,6-
R L, Koder, O, Oyedele, A F, Miller
openaire +2 more sources