Green and sustainable LC-APCI-MS/MS method for simultaneous quantification of genotoxic nitrosamines in antidiabetic medication: sitagliptin. [PDF]
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Deriving safe limits for N-nitroso-bisoprolol by error-corrected next-generation sequencing (ecNGS) and benchmark dose (BMD) analysis, integrated with QM modeling and CYP-docking analysis. [PDF]
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Guidelines for the assessment and control of mutagenic impurities in pharmaceuticals. [PDF]
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This chapter looks into the synthesis and reactions of N-oxides. The N-heteroatom bond of N-oxides is not introduced intact in the synthesis of compounds. However, it is delivered in an oxidation reaction. It notes peracid as the usual oxidant which is either used directly or generated in place from a carboxylic acid or hydrogen peroxide mixture.
Patrick D. Bailey, Keith M. Morgan
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