Results 91 to 100 of about 18,603 (231)

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine [PDF]

, 2003
Reactive nitrogen species, such as peroxynitrite, can nitrate tyrosine in proteins to form nitrotyrosine. Nitrotyrosine is metabolized to 3-nitro-4-hydroxyphenylacetic acid (NHPA), which is excreted in the urine.
Orie, N.N., Harry, D., Moore, K P, Mani, A.R., Harry, D, Rice-Evans, C A, Mani, A R, Pannala, A S, Orie, N N, Moore, K.P., Rice-Evans, C.A., Ollosson, R, Pannala, A.S.; id_orcid, Ollosson, R.   +13 more
core   +1 more source

Oxidative stress parameters and inflammatory and immune mediators as markers of the severity of sepsis

Journal of Infection in Developing Countries, 2016
Introduction: Sepsis is a complex inflammatory syndrome with diverse etiology and wide spectrum of severity. The aim of this study was to investigate whether inflammatory mediators, in comparison with oxidative parameters, are associated with severity of
Isil Bavunoglu, Habibe Genc, Dildar Konukoglu, Hayriye Cicekci, Volkan Sozer, Remise Gelisgen, Hafize Uzun   +6 more
doaj   +1 more source

A Non‐Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

Aging Cell, Volume 25, Issue 7, July 2026.
Aging‐associated MLKL upregulation in hepatocytes induces mitochondrial dysfunction and oxidative stress, accompanied by increased release of pro‐inflammatory extracellular vesicles. These changes are associated with increased p16+/p21+ senescence in hepatocytes and non‐parenchymal cells (macrophages, stellate cells, and endothelial cells), suggesting ...
Sabira Mohammed, Chao Jiang, Travis Pennington, Shylesh Bhaskaran, Phoebe Ohene‐Marfo, Kara F. Kneuper, Constantin Georgescu, Kamille Pitts, Albert Tran, Zongkai Peng, Amit Singh, Zhibo Yang, Tiangang Li, Bethany Hannafon, Courtney Houchen, Jonathan D. Wren, Andriy Yabluchanskiy, Veronica Galvan, Nagib Ahsan, Michael Kinter, Tommy L. Lewis Jr, Sathyaseelan S. Deepa   +21 more
wiley   +1 more source

Protein 3-nitrotyrosine formation during Trypanosoma cruzi infection in mice [PDF]

, 2005
Nitric oxide (·NO) is a diffusible messenger implicated in Trypanosoma cruzi resistance. Excess production of ·NO and oxidants leads to the generation of nitrogen dioxide (·NO2), a strong nitrating agent.
G. Gualco, A. Cayota, M. Naviliat, R. Radi   +3 more
core   +1 more source

Nitric oxide: a pro-inflammatory mediator in lung disease?

Respiratory Research, 2000
Inflammatory diseases of the respiratory tract are commonly associated with elevated production of nitric oxide (NO•) and increased indices of NO• -dependent oxidative stress.
Eiserich Jason P, Vliet Albert van der, Cross Carroll E   +2 more
doaj   +1 more source

Requirements for heme and thiols for the nonenzymatic modification of nitrotyrosine

Proceedings of the National Academy of Sciences, 1999
Peroxynitrite-dependent formation of nitrotyrosine has been associated with inactivation of various enzymes and proteins possessing functionally important tyrosines. We have previously reported an enzymatic activity modifying the nitrotyrosine residues in nitrated proteins.
B, Balabanli, Y, Kamisaki, E, Martin, F, Murad   +3 more
openaire   +3 more sources

Environmental Transformation and Trophic Transfer of Engineered Nanomaterials in the Agri‐Food Chain and Implications for human Health

ChemFoodChem, Volume 2, Issue 2, June 2026.
ABSTRACT Engineered nanomaterials (ENMs) are increasingly applied in agriculture to improve crop yield, nutrient efficiency, and food quality. This study examines the environmental transformation of ENMs, their uptake in plants, and their transfer across the agri‐food chain leading to human exposure.
Soumitra Nath
wiley   +1 more source

Generation of novel recombinant antibodies against nitrotyrosine by antibody phage display [PDF]

, 2011
Nitrotyrosine is a posttranslational protein modification that occurs under oxidative and nitrosative stress, and plays an important role in numerous pathological conditions. To analyse nitrotyrosine formation several commercial monoclonal and polyclonal
Moergeli, S, Seraina Cooksley-Decasper, Sandra Moergeli, Cooksley-Decasper, S, Arnold von Eckardstein, Hof, D, von Eckardstein, Arnold, Danielle Hof   +7 more
core   +1 more source

Hypoxia-Induced Pulmonary Injury—Adrenergic Blockade Attenuates Nitrosative Stress, and Proinflammatory Cytokines but Not Pulmonary Edema

Journal of Cardiovascular Development and Disease
Hypoxia can induce pulmonary edema (PE) and inflammation. Furthermore, hypoxia depresses left ventricular (LV) inotropy despite sympathetic activation. To study the role of hypoxic sympathetic activation, we investigated the effects of hypoxia with and ...
Isabel Riha, Aida Salameh, Annekathrin Hoschke, Coralie Raffort, Julia Koedel, Beate Rassler   +5 more
doaj   +1 more source