Results 91 to 100 of about 113,543 (162)

Biophysical Characterization of Endotoxin Inactivation by NK-2, an Antimicrobial Peptide Derived from Mammalian NK-Lysin

, 2004
NK-2, a membrane-acting antimicrobial peptide, was derived from the cationic core region of porcine NK-lysin and consists of 27 amino acid residues. It adopts an amphipathic, α-helical secondary structure and has been shown to interact specifically with ...
Brandenburg, K., Andra, J., Bartels, R., Koch, M. H. J., Andrä, Jörg, Brandenburg, Klaus, Bartels, Rainer, Koch, Michel H. J.   +7 more
core   +1 more source

IL-2 stimulated but not unstimulated NK cells induce selective disappearance of peripheral blood cells: concomitant results to a phase I/II study [PDF]

, 2011
In an ongoing clinical phase I/II study, 16 pediatric patients suffering from high risk leukemia/tumors received highly purified donor natural killer (NK) cell immunotherapy (NK-DLI) at day (+3) +40 and +100 post haploidentical stem cell transplantation.
Claudia Brehm, Bader Peter, Soerensen, Jan, Klingebiel Thomas, Seidl, Christian, Christian Seidl, Petra S. A. Becker, Bremm Melanie, Koehl Ulrike, Becker, Petra S. A., Jakob R. Passweg, Sabine Huenecke, Andrea Quaiser, Peter Bader, Koehl, Ulrike, Thomas Klingebiel, Ulrike Koehl, Jakob R Passweg, Brehm Claudia, Jan Soerensen, Hermann Kreyenberg, Schwabe Dirk, Becker Petra S. A., Brehm, Claudia, Quaiser, Andrea, Petra S A Becker, Bader, Peter, Sörensen, Jan, Mühl Heiko, Stephan Kloess, Huenecke, Sabine, Mühl, Heiko, Klingebiel, Thomas, Esser Ruth, Klöß, Stephan, Esser, Ruth, Hünecke, Sabine, Kloess, Stephan, Huenecke Sabine, Kreyenberg Hermann, Seidl Christian, Melanie Bremm, Kreyenberg, Hermann, Bremm, Melanie, Heiko Mühl, Ruth Esser, Dirk Schwabe, Soerensen Jan, Köhl, Ulrike, Quaiser Andrea, Passweg, Jakob R., Schwabe, Dirk, Kloess Stephan, Passweg Jakob R.   +53 more
core   +1 more source

Characterization of NK-lysin A, a potent antimicrobial peptide from the zebrafish Danio rerio

Developmental & Comparative Immunology
Antimicrobial peptides (AMPs) are important players of the innate immune system with a major role in the defense against invading pathogens. AMPs belonging to the family of saposin-like proteins (SAPLIPs) include the porcine NK-lysin and the human granulysin.
Marius Ortjohann, Matthias Leippe
openaire   +2 more sources

Molecular basis for membrane selectivity of NK-2, a potent peptide antibiotic derived from NK-lysin

, 2003
Increasing resistance of pathogenic bacteria against antibiotics is a severe problem in health care. Natural antimicrobial peptides and derivatives thereof have emerged as promising candidates for “new antibiotics”.
Brandenburg, Klaus, Andrä, Jörg, Schröder-Borm, Hannah, Willumeit, Regine   +3 more
core   +1 more source

NK-lysin, a disulfide-containing effector peptide of T-lymphocytes, is reduced and inactivated by human thioredoxin reductase. Implication for a protective mechanism against NK-lysin cytotoxicity.

The Journal of biological chemistry, 1996
The cytotoxic and antibacterial polypeptide NK-lysin has a molecular mass of approximately 9 kDa and contains three disulfide bonds. The activity was highly dependent on intact disulfides, because the bactericidal effect on Escherichia coli and the cytolytic effect on human 3B6 lymphocytes was inhibited when NK-lysin was treated with dithiothreitol ...
M, Andersson, A, Holmgren, G, Spyrou
openaire   +1 more source

PI uptake of M. bovis following incubation with bovine NK-lysin peptides.

, 2018
M. bovis was incubated with PI (3 μM final concentration) for 5 min followed by addition of 20 μM (A) and 5 μM (B) final concentrations of NK-lysin peptides and PI fluorescence was immediately measured using a fluorescent microplate reader with ...
Rohana P. Dassanayake (2802847), Karen B. Register (618336), Daniel Samorodnitsky (327419), Timothy A. Reinhardt (330115), Shollie M. Falkenberg (4379413), Eric M. Nicholson (159301)   +5 more
core   +1 more source

A Modified Variant of Fasciola hepatica FhSAP-2 (mFhSAP-2) as a Recombinant Vaccine Candidate Induces High-Avidity IgG2c Antibodies and Enhances T Cell Activation in C57BL/6 Mice

Vaccines
Background/Objectives: In the past, FhSAP-2, an 11.5 kDa recombinant protein belonging to the Fasciola hepatica saposin-like/NK-lysin family, has been shown to induce over 60% partial protection in immunized rabbits and mice when challenged with F ...
Riseilly Ramos-Nieves, Albersy Armina-Rodriguez, Maria Del Mar Figueroa-Gispert, Ghalib Figueroa-Quiñones, Carlimar Ocasio-Malavé, Ana M. Espino   +5 more
doaj   +1 more source

Bacteriocin AS-48, a microbial cyclic polypeptide structurally and functionally related to mammalian NK-lysin

, 2000
The solution structure of bacteriocin AS-48, a 70-residue cyclic polypeptide from Enterococcus faecalis, consists of a globular arrangement of five α-helices enclosing a compact hydrophobic core.
González, Carlos, Gálvez, Antonio, Valdivia, E., Bruix Bayés, Marta, Rico, Manuel, Maqueda, Mercedes, Langdon, Grant M., Antonio Gálvez, Grant M. Langdon, Bruix, M., Carlos González, Marta Bruix, Eva Valdivia, Manuel Rico, Mercedes Maqueda   +14 more
core   +1 more source

Bovine Nk-Lysins: Genomic Expansion and Functional Diversification [PDF]

, 2016
NK-lysin is a cationic antimicrobial peptide (AMP) of the host innate immune system and active against a broad spectrum of targets, including bacteria, viruses, fungi and cancer cells.
Chen, Junfeng
core  

Plasma membrane depolarization activity of bovine NK-lysin peptides on M. bovis.

, 2018
M. bovis was incubated with membrane-potential sensitive cyanine dye DiSC3(5) (0.4 μM final concentration) at 37°C for 30 min followed by addition of KCl (100 mM final concentration). Bovine NK-lysin peptides (5 and 20 μM final concentrations) were added
Rohana P. Dassanayake (2802847), Karen B. Register (618336), Daniel Samorodnitsky (327419), Timothy A. Reinhardt (330115), Shollie M. Falkenberg (4379413), Eric M. Nicholson (159301)   +5 more
core   +1 more source