Results 131 to 140 of about 113,543 (162)

Characterization of Japanese Flounder (Paralichthys olivaceus) NK-Lysin, an Antimicrobial Peptide

Fish and Shellfish Immunology, 2007
The NK-lysin cDNA of Japanese flounder, Paralichthys olivaceus, consists of 657bp, containing an open reading frame (ORF) of 444bp, which encodes 147 amino acid residues. The amino acid sequence of Japanese flounder NK-lysin has 21% identity to porcine NK-lysin and bovine NK-lysin, 23% to equine NK-lysin, and 46% to zebrafish NK-lysin-like protein ...
Hidehiro Kondo, Takashi Koyama, Ikuo Hirono   +2 more
exaly   +3 more sources

Molecular characterization and antimicrobial activity of NK-lysin in black scraper (Thamnaconus modestus)

Fish & Shellfish Immunology, 2023
NK-lysin (NKL) is a positively charged antimicrobial peptide with broad-spectrum bactericidal activities. In this study, the cDNA sequence of NKL (TmNKL) from black scraper (Thamnaconus modestus) was cloned, which encodes a predicted polypeptide of 150 amino acids that contains a surfactant protein B domain with three disulfide bonds. Phylogenetically,
Mei-Yi, Liu, Yi-Rong, Zhang, Jian-Hua, Zhang, Liang, Miao, Yun-Fei, Dang, Chen-Jie, Fei, Chang-Hong, Li, Jiong, Chen   +7 more
openaire   +2 more sources

NKHs27, a sevenband grouper NK-Lysin peptide that possesses immunoregulatory and antimicrobial activity

Fish & Shellfish Immunology, 2023
As an effective and broad-spectrum antimicrobial peptide, NK-Lysin is attracted more and more attention at present. However, the functions and action mechanism of NK-Lysin peptides are still not comprehensive enough at present. In this study, a sevenband grouper (Hyporthodus septemfasciatus) NK-Lysin peptide, NKHs27, was identified and synthesized, and
Chang-Biao, Wang, Xue, Yan, Guang-Hua, Wang, Wen-Qing, Liu, Yue, Wang, Dong-Fang, Hao, Hong-Mei, Liu, Min, Zhang   +7 more
openaire   +2 more sources

Antimicrobial Activity of Chicken NK-Lysin Against Eimeria Sporozoites

Avian Diseases Digest, 2008
NK-lysin is an antimicrobial and antitumor polypeptide that is considered to play an important role in innate immunity. Chicken NK-lysin is a member of the saposin-like protein family and exhibits potent antitumor cell activity. To evaluate the antimicrobial properties of chicken NK-lysin, we examined its ability to reduce the viability of various ...
Yeong H, Hong, Hyun S, Lillehoj, Gregory R, Siragusa, Douglas D, Bannerman, Erik P, Lillehoj   +4 more
openaire   +2 more sources

Characterization of a NK-lysin antimicrobial peptide gene from channel catfish

Fish & Shellfish Immunology, 2006
Auburn Univ, Dept Fisheries & Allied Aquacultures, Fish Mol Genet & Biotechnol Lab, Auburn, AL 36849 USA; Auburn Univ, Program Cell & Mol Biosci, Aquat Genom Unit, Auburn, AL 36849 USA; E China Normal Univ, Shanghai 200062, Peoples R China; Shanghai Fisheries Univ, Coll Aquat Life Sci & Technol, Shanghai 200090, Peoples R China; Chinese Acad Sci, Inst ...
Qun, Wang, Baolong, Bao, Yaping, Wang, Eric, Peatman, Zhanjiang, Liu   +4 more
openaire   +2 more sources

Effect of a single polymorphism in the Japanese quail NK‐lysin gene on antimicrobial activity

Animal Science Journal, 2015
AbstractNK‐lysins are cationic peptides that play important roles in host protection, and are an important constituent of innate immunity. We identified nine single‐nucleotide polymorphisms (SNPs) in the NK‐lysin open reading frame (ORF) from 32 Japanese quails in six strains: A, B, ND, K, P, and Y. The G to A substitution at nucleotide position 272 in
Taichiro, Ishige, Hiromi, Hara, Takashi, Hirano, Tomohiro, Kono, Kei, Hanzawa   +4 more
openaire   +2 more sources

Functional characterization of NK-lysin in golden pompano Trachinotus ovatus (Linnaeus 1758)

Developmental & Comparative Immunology, 2020
NK-lysin is an important part of the innate immune defence system and plays an important role in resisting the invasion of pathogenic microorganisms. In this study, NK-lysin from golden pompano (Trachinotus ovatus) was characterized and its expression in response to Photobacterium damselae was investigated.
Bo, Liu, Guang-Dong, Liu, Hua-Yang, Guo, Ke-Cheng, Zhu, Liang, Guo, Bao-Suo, Liu, Nan, Zhang, Shi-Gui, Jiang, Dian-Chang, Zhang   +8 more
openaire   +2 more sources

Interaction of Amoebapores and NK-Lysin with Symmetric Phospholipid and Asymmetric Lipopolysaccharide/Phospholipid Bilayers

Biochemistry, 2003
Amoebapores from protozoan parasite Entamoeba histolytica and NK-lysin of porcine cytotoxic lymphocytes belong to the same family of saposin-like proteins. In addition to the structural similarity, amoebapores and NK-lysin are both highly effective against prokaryotic and eukaryotic target cells in that they permeabilize the target cell membranes. Here,
Thomas, Gutsmann, Beate, Riekens, Heike, Bruhn, Andre, Wiese, Ulrich, Seydel, Matthias, Leippe   +5 more
openaire   +2 more sources

Recombinant porcine NK-lysin inhibits the invasion of hepatocellular carcinoma cells in vitro

International Journal of Biological Macromolecules, 2019
The therapeutics having ability to target cancer cells specifically and exhibit nominal cytopathic effect on normal healthy cells are highly significant for cancer therapeutic applications. Recombinant porcine natural killer lysin (rpNK-lysin) has proven cationic anti-bacterial and anti-tumor peptide.
Ajab, Khan, Kuohai, Fan, Na, Sun, Wei, Yin, Yaogui, Sun, Panpan, Sun, Ali Raza, Jahejo, Hongquan, Li   +7 more
openaire   +2 more sources

Membrane disruptive antimicrobial potential of NK-lysin from yellow catfish (Pelteobagrus fulvidraco)

Fish & Shellfish Immunology, 2020
NK-lysins, a type of broad-spectrum antimicrobial peptide (AMP), act as an essential effector of innate defense against microbial attack in higher vertebrates and so in fish. The present study delineates the structural and functional characterization of NK-lysin from yellow catfish (Pelteobagrus fulvidrac) (Pelteobagrus fulvidraco).
Rong, Zhu, Yin-Sheng, Wu, Xiao-Xiao, Liu, Xue, Lv, Ye-Qing, Wu, Jing-Jing, Song, Xing-Guo, Wang   +6 more
openaire   +2 more sources