Results 131 to 140 of about 7,196 (266)

Reverse Micelles: The Gateway for Oral (Poly)Peptide Delivery

Small, EarlyView.
RM achieve superior oral peptide delivery through high loading capacity, strong lipophilicity, and a low‐hydration microenvironment that protects against enzymatic degradation. Meanwhile, dRM provides favorable permeation‐enhancing interactions and a consistent safety profile, collectively driving enhanced oral performance.
Marlene Ramona Schmidt, Melanie Lena Ebert, Andreas Bernkop‐Schnürch   +2 more
wiley   +1 more source

Surface Rights: Sovereignty, Citizenship and the Question of Mineral Rights in the Woodward Commission

Australian Journal of Politics &History, EarlyView.
ABSTRACT This article retraces the Woodward Commission on Aboriginal Land Rights in the Northern Territory, focusing on the question of mineral rights. Mineral rights were assumed in the Commission's terms of reference and expected by many Aboriginal people. Why, then, were they not recommended by the Commission?
Laura Rademaker
wiley   +1 more source

A Gastric Cancer Peptide GX1-Modified Nano-Lipid Carriers Encapsulating Paclitaxel: Design and Evaluation of Anti-Tumor Activity

Drug Design, Development and Therapy, 2020
Yufan Jian,1,2,* Meina Zhao,1,2,* Jinyi Cao,1,* Tingting Fan,1 Wei Bu,1 Yang Yang,3 Weiwei Li,1 Wei Zhang,1 Yi Qiao,1 Jingwen Wang,1 Aidong Wen1,2 1Department of Pharmacy, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032 ...
Jian Y, Zhao M, Cao J, Fan T, Bu W, Yang Y, Li W, Zhang W, Qiao Y, Wang J, Wen A   +10 more
doaj  

Proteomic Sex Estimation From Embedded Tooth Enamel

Archaeometry, EarlyView.
ABSTRACT Teeth hold insights into childhood diet, health and demography—including chromosomal sex. Proteomic analysis can detect peptide biomarkers from amelogenin genes encoded on X and Y chromosomes, allowing sex estimation. Embedding resins, necessary for thin sectioning teeth, can damage analytical systems, preventing proteomic analysis. We present
E. L. Sudron, G. Parker, T. Buonasera, K. Burk, C. Canzonieri, J. W. Eerkens, M. Ehlers, D. Loo‐Oey, C. Matheson, M. Salemi, C. Zimmer, T. M. Smith   +11 more
wiley   +1 more source

Formulation of a multiscale fluid gel based on nanostructure lipid carriers (NLCs) for wound-healing applications.

, 2019
National audienceSkin’s regeneration emerges as a main challenge for both medicine and cosmetics. Cosmeceutics can be defined as cosmetics in which the active ingredient has a proven therapeutic effect.
Gentilli, Marianna, Schoenstein, Frédéric, Pauthe, Emmanuel, Calderon-Jacinto, Rosa, Abraham, Sandrine, Matricardi, Pietro, Sandhu, Serena, Lopez, Danisa, Gueguen, Virginie, Rodriguez-Ruiz, Violeta, Pavon-Djavid, Graciela   +10 more
core   +2 more sources

Limits on the Bess Model at NLC

, 1993
Invited talk at the ``Workshop on Physics and Experiments at Linear e+e- Colliders'', Waikoloa, Hawaii, April 26-30, 1993 (presented by D. Dominici)
Casalbuoni, R., De Curtis, S., Dominici, D., Chiappetta, P., Deandrea, A., Gatto, R.   +5 more
openaire   +2 more sources

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

Lymph-Targeted Delivery of CUR-NLCs Enhances Oral Bioavailability: Evidence from a Double-Catheterized Rat Model

Background/Objectives: Curcumin (CUR), a natural polyphenol with poor solubility and significant first-pass metabolism, shows extremely low oral bioavailability.
Daojin Yu, Qiuyong Chen, Hui Deng, Bo Yang, Zhiyuan Chen, Xiaorui Zhang, Haoming Chi   +6 more
core   +1 more source

Purpurin Alleviates Meniscal Senescence and Osteoarthritis by Blocking the Non‐Metabolic Function of Hexokinase 2

Cell Proliferation, EarlyView.
HK2 is upregulated in osteoarthritis and accelerates disease progression via a glycolysis‐independent non‐metabolic mechanism. It recruits PRKN to degrade MYH10, reducing COL1A1 mRNA stability and inducing senescence. Purpurin disrupts this pathogenic pathway with therapeutic potential.
Zhencan Lin, Ming Li, Wei Li, Tianfa Xu, Zongrui Jiang, Yanlin Zhong, Aishan He, Xiaoyi Zhao, Dianbo Long, Yan Kang   +9 more
wiley   +1 more source

A comprehensive study on ferredoxin isoforms in the cyanobacterium Synechocystis sp. PCC 6803

The FEBS Journal, EarlyView.
Ferredoxins are small FeS cluster‐containing proteins that play a central role in distributing electrons within the cell. The cyanobacterium Synechocystis sp. PCC 6803 contains several ferredoxin isoforms and their biophysical properties (UV/Vis and EPR spectra, Em potential), expression patterns, and interactions with the electron donors photosystem I
Marko Boehm, Drazenka Svedruzic, Carolyn E. Lubner, Jens Appel, David W. Mulder, Effie C. Kisgeropoulos, Vanessa Hueren, Katharina Spengler, Vivek S. Bharadwaj, Zhanjun Guo, Anastasia E. Ledinina, Darja Deobald, Lorenz Adrian, Paul W. King, Kirstin Gutekunst   +14 more
wiley   +1 more source