Results 171 to 180 of about 191,890 (217)
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Current Opinion in Immunology, 2015
Intracellular immune receptors with nucleotide-binding, leucine-rich domains (NLRs) are found in both plants and animals. Compared to animals, NLR-encoding gene families are expanded, more prevalent and have enriched diversity in higher plants. Strong host defense triggered by the recognition of specific pathogen effectors constitutes a major part of ...
Xin Li, Paul Kapos, Yuelin Zhang
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Intracellular immune receptors with nucleotide-binding, leucine-rich domains (NLRs) are found in both plants and animals. Compared to animals, NLR-encoding gene families are expanded, more prevalent and have enriched diversity in higher plants. Strong host defense triggered by the recognition of specific pathogen effectors constitutes a major part of ...
Xin Li, Paul Kapos, Yuelin Zhang
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Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme
Science, 2020Tetrameric immune receptors Nucleotide-binding/leucine-rich repeat (NLR) immune receptors detect pathogen effectors and trigger a plant's immune response. Two groups have now defined the structures of two NLRs that carry Toll-like interleukin-1 receptor (
Shoucai Ma +13 more
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The evolution of plant NLR immune receptors and downstream signal components.
Current opinion in plant biology, 2023Along with the emergence of green plants on this planet one billion years ago, the nucleotide binding site leucine-rich repeat (NLR) gene family originated and diverged into at least three subclasses.
Yang Liu +4 more
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Method to Measure Ubiquitination of NLRs
2023Posttranslational modifications are crucial in determining the functions of proteins in the cell. Modification of the NLRP3 inflammasome by the ubiquitin system has recently emerged as a new level of regulation of the inflammasome complex. Here we describe a method to detect poly-ubiquitination of NRLP3 using two different approaches: (i) detection ...
Worboys, Jonathan D; id_orcid 0000-0002-8242-4901 +2 more
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Indirect recognition of pathogen effectors by NLRs
Essays in Biochemistry, 2022Abstract To perceive pathogen threats, plants utilize both plasma membrane-localized and intracellular receptors. Nucleotide-binding domain leucine-rich repeat containing (NLR) proteins are key receptors that can recognize pathogen-derived intracellularly delivered effectors and activate downstream defense.
Kevin Ao, Xin Li
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Scientific Reports
To evaluate the clinical utility of PCT, CRP, IL-6, NLR, and TyG index in improving the early diagnosis and severity assessment of acute pancreatitis (AP).
Xu Xinyu +5 more
semanticscholar +1 more source
To evaluate the clinical utility of PCT, CRP, IL-6, NLR, and TyG index in improving the early diagnosis and severity assessment of acute pancreatitis (AP).
Xu Xinyu +5 more
semanticscholar +1 more source
Seminars in Immunopathology, 2007
The present issue, which is dedicated to the NOD-like receptors (NLRs), is particularly timely since there is burgeoning evidence that these molecules play a pivotal role in an expanding number of monogenic and polygenic disease. At the molecular level the NLR family of molecules plays a key role as pattern recognition receptors for intracellular ...
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The present issue, which is dedicated to the NOD-like receptors (NLRs), is particularly timely since there is burgeoning evidence that these molecules play a pivotal role in an expanding number of monogenic and polygenic disease. At the molecular level the NLR family of molecules plays a key role as pattern recognition receptors for intracellular ...
openaire +2 more sources
Method to Measure Ubiquitination of NLRs
2016Posttranslational modifications are crucial in determining the functions of proteins in the cell. Modification of the NLRP3 inflammasome by the ubiquitin system has recently emerged as a new level of regulation of the inflammasome complex. Here, we describe a method to detect polyubiquitination of NRLP3 using two different approaches: (1) detection ...
Palazón, Pablo, Lopez-Castejon, Gloria
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Journal of Gastrointestinal Surgery, 2013
The neutrophil-lymphocyte ratio (NLR), calculated from the white cell differential count, provides a rapid indication of the extent of an inflammatory process. The aim of this study was to investigate the prognostic value of the NLR in acute pancreatitis (AP) and determine an optimal ratio for severity prediction.NLRs were calculated on days 0, 1, and ...
Aravind, Suppiah +6 more
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The neutrophil-lymphocyte ratio (NLR), calculated from the white cell differential count, provides a rapid indication of the extent of an inflammatory process. The aim of this study was to investigate the prognostic value of the NLR in acute pancreatitis (AP) and determine an optimal ratio for severity prediction.NLRs were calculated on days 0, 1, and ...
Aravind, Suppiah +6 more
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NLR functions beyond pathogen recognition
Nature Immunology, 2011The last 10 years have witnessed the identification of a new class of intracellular pattern-recognition molecules--the nucleotide-binding domain and leucine-rich repeat-containing family (NLR). Members of this family garnered interest as pattern-recognition receptors able to trigger inflammatory responses against pathogens.
Kufer, Thomas A, Sansonetti, Philippe J
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