Results 181 to 190 of about 191,890 (217)
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The role of NLRs and TLRs in the activation of the inflammasome
Expert Opinion on Biological Therapy, 2008Interleukin-1 beta is one of the most important pro-inflammatory cytokines. In contrast to other cytokines, activation of IL-1 beta requires processing from an inactive precursor by the cysteine protease caspase-1. Caspase-1 forms a protein platform called the inflammasome, together with proteins of the nucleotide-binding oligomerization domain-like ...
Netea, M.G. +5 more
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Dual Regulation of NLR Activation by Phosphorylation
Trends in Plant Science, 2020The arabidopsis paired RRS1/RPS4 immune receptor complex has an essential role in resistance against several pathogens. A recent study by Guo et al. found that specific phosphorylation of RRS1-R reconfigures the complex, thereby activating the resistance reaction.
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NLRs at the intersection of cell death and immunity
Nature Reviews Immunology, 2008Inflammation is a crucial element of the host response to cellular insult. Pathogen-induced inflammation includes a molecular pathway which proceeds through activation of the protease caspase-1 to the release of the inflammatory cytokines interleukin-1 (IL-1) and IL-18. Importantly, pathogens may also induce forms of cell death that have inherently pro-
Jenny P-Y, Ting +2 more
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Functional Reconstruction of NLRs in HEK293 Cells
2016Inflammasomes are molecular complexes that initiate innate immune response. They are mainly expressed by immune cells; however, molecular manipulations in these cells remain very difficult. Here, we describe a simple protocol to overexpress and activate functional NRLP3 inflammasomes in HEK293 cells.
Compan, Vincent, Lopez-Castejon, Gloria
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NLR activation takes a direct route
Trends in Biochemical Sciences, 2013For the first time there is now clear biochemical and biophysical evidence indicating that members of the nucleotide-binding domain and leucine-rich repeat containing (NLR) family can be activated as a result of direct interaction between the receptor and ligand.
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The expanding world of plant NLR pairs
Trends in Plant ScienceThree recent studies, by Zhu et al.,Klymiuk et al., and Hu et al., identified paired nucleotide-binding site-leucine-rich repeat receptors (NLRs) in wheat against different pathogens, providing new insights into the genomic organization, domain architecture, and function of plant NLR pairs.
Cheng-Wei Sang +4 more
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NLRs form ‘resistosome channels’
Nature Structural & Molecular Biology, 2021openaire +2 more sources
Assembly and Architecture of NLR Resistosomes and Inflammasomes
Annual Review of Biophysics, 2023Zehan Hu, Jijie Chai
exaly