Results 61 to 70 of about 229,010 (267)

Epithelial SLC25A20 Deficiency Drives Immunosuppressive Neutrophil Remodeling via ARG1 Palmitoylation to Promote Colorectal Cancer

Advanced Science, EarlyView.
SLC25A20 deficiency in tumor cells compromises mitochondrial LCFA transport, which suppresses FAO and drives compensatory release of palmitic acid‐enriched lipids into the TME. These tumor‐derived palmitic acids are taken up by TANs, promoting ZDHHC18‐catalyzed ARG1 palmitoylation.
Yue Han, Tian‐Yuan Tan, Bin Zhang, Ye‐Bin Fu, Wen Chen, Min‐Hui Yang, Yi‐Qing Wang, Yan‐Qing Ding, Shuang Wang   +8 more
wiley   +1 more source

System Analysis and Comparison Between a 2 MW Conventional Liquid Cooling System and a Novel Two-Phase Cooling System for Fuel Cell-Powered Aircraft

Energies
Hydrogen-powered fuel cells are the preferred energy source for electric aircraft. However, for aircraft applications, it is of upmost importance to reduce the mass of the fuel cell system.
Henk Jan van Gerner, Tim Luten, William Resende, Georg Mühlthaler, Marcus-Benedict Buntz   +4 more
doaj   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Effect of sowing methods and sowing rate in organic seed production of timothy (Phleum pratense L.), meadow fescue (Festuca pratensis Huds.) and red clover (Trifolium pratense L.)

Acta Agriculturae Scandinavica. Section B, Soil and Plant Science, 2017
Different sowing methods and sowing rates were evaluated in organic seed production of timothy (two trials), meadow fescue (two trials) and red clover (one trial) in Southeast Norway, during 2010–2013.
Lars T. Havstad, John Ingar Øverland
doaj   +1 more source

A Compact and Fast Single‐Spike TTFS Encoder With Ultralow Operating Voltage for Efficient Neuromorphic Fourier Transform

Advanced Science, EarlyView.
A Pt/TaOx/V single‐spike TTFS encoder achieves ultralow‐voltage (∼0.35 V), high‐speed (∼100 ns) operation with simplified circuitry. Integrating bipolar nonuniform temporal encoding with a spiking‐DFT neuron model enables a neuromorphic FFT framework. Device‐calibrated simulations demonstrate high spectral fidelity across multitone, speech, and chirp ...
Yang Wu, Qi Wei, Junfeng Zhang, Lirou Su, Ning Mao, Beibei Huang, Jiaying Chen, Dian Huang, Shengzhong Feng, Yishu Zhang, Shuai Zhong   +10 more
wiley   +1 more source

The reliability of clinical judgments in dermatology: a descriptive review on their role as a reference standard for technological diagnostic research

Dermatology Reports
The expansion of dermatological mobile health (mHealth) and teledermatology has generated numerous diagnostic support tools, typically validated against traditional face-to-face assessments. Histopathological confirmation through skin biopsy is invasive,
Nelly Mwageni, Robin van Wijk, Anne Schoenmarkers, John Elisante Masenga, Christa Kasang, Liesbeth Mieras, Stephen E. Mshana   +6 more
doaj   +1 more source

Intratumoral Fusogenic Outer Membrane Vesicles Enhance Antitumor Immunity Through Tumor MHC‐I Upregulation and Tumor Bacterization

Advanced Science, EarlyView.
Tumor bacterization by fusogenic outer membrane vesicles enhances microbial‐like recognition of tumor cells while activating the TLR4–NF‐κB–NLRC5 axis to upregulate MHC class I expression. By simultaneously strengthening APC sensing and T‐cell recognition, this strategy breaks tumor immune invisibility and promotes more effective antitumor immune ...
Xing Liu, Jiaxin Zhou, Guihong Lu, Chenjing Zhao, Weixiu Wang, Jichuan Chen, Fengqi Zhang, Fan Zhang, Hai‐Yan Xie, Weidong Nie   +9 more
wiley   +1 more source

Relationship of Peripheral Blood Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio with Curative Effect and Prognosis of Patients with Locally Advanced Nasopharyngeal Carcinoma

Zhongliu Fangzhi Yanjiu, 2019
Objective To explore the predictive value of neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio (PLR) in the prognosis and curative effect of locally advanced nasopharyngeal carcinoma(NPC) patients.
TANG Hong, WU Weili, JIN Feng, LONG Jinhua, LI Yuanyuan, LUO Xiuling, GONG Xiuyun, CHEN Xiaoxiao, ZHANG Mang, YANG Chunli   +9 more
doaj   +1 more source

Modulator NLR has evolved to maintain NLR network homeostasis.

, 2023
We propose that “Modulator NLR” contributes to NLR immune receptor network homeostasis during plant growth. A modulator NRCX has a similar sequence signature with helper MADA-CC-NLRs, but unlike helpers, NRCX lacks the functional MADA motif to execute ...
Chih-hang Wu (7056494), Hiroaki Adachi (133026), Sophien Kamoun (6132), Jules Claeys (14474854), Toshiyuki Sakai (309632), Tolga O. Bozkurt (14020459), Hsuan Pai (13844742), AmirAli Toghani (14474851), Cian Duggan (7056497), Adeline Harant (4783905), Kodai Honda (14474848)   +10 more
core   +1 more source

PDHA1 Hyperactivation‐Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury

Advanced Science, EarlyView.
During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu, Wen‐Jing Zhong, Chen‐Yu Zhang, Meng‐Rui Chen, Nan‐Shi‐Yu Yang, Han‐Xi Sha, Yan‐Ling Qiu, Hui Chen, Jin‐Tong Yang, Li‐Ying Liang, Jian‐Bing Xiong, Shao‐Kun Liu, Cha‐Xiang Guan, Jia‐Xi Duan, Yong Zhou   +14 more
wiley   +1 more source