Results 61 to 70 of about 192,001 (267)

Aircraft Level Thermal Management Analysis for Early Design Stages of Future Aircraft: Integration of Systems and Compartments into an Interacting Generic Approach

Engineering Proceedings
For future commercial aircraft having hybrid electric drivetrains, the impact of electrical power generation and distribution on heat production and required heat rejection is of a larger magnitude than for conventional aircraft.
Jaap van Muijden, Jos Aalbers
doaj   +1 more source

Structural mechanisms in NLR inflammasome signaling [PDF]

Current Opinion in Structural Biology, 2014
Members of the NOD-like receptor (NLR) family mediate the innate immune response to a wide range of pathogens, tissue damage and other cellular stresses. They achieve modulation of these signals by forming oligomeric signaling platforms, which in analogy to the apoptosome are predicted to adopt a defined oligomeric architecture and will here be ...
Bernhard C, Lechtenberg, Peter D, Mace, Stefan J, Riedl   +2 more
openaire   +2 more sources

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

From words to action: the development of the Neglected Tropical Disease Inclusion Score Card (NISC)

Infectious Diseases of Poverty
Background The importance of patient participation in designing and delivering services for persons affected by neglected tropical diseases (NTDs) has gained increasing recognition.
Robin van Wijk, Surya J. M. Baudoin, Bernice Ejiogu, Upasana Regmi, Mathias Duck, Ibrahim Rabiu, Constanze Vettel, Heleen Broekkamp, Roos Geutjes, Ruth M. H. Peters, Ida J. Korfage   +10 more
doaj   +1 more source

Retrofitted Hydrogen-Electric Propulsion Aircraft: Performance Simulation of Critical Operating Conditions

Aerospace
Retrofitting regional turboprop aircraft with hydrogen (H2)-electric powertrains, using fuel cell systems (FCSs), has gained interest in the last decade. This type of powertrain eliminates CO2, NOx, and fine particle emissions during flight, as FCSs only
Wim Lammen, Pieter-Jan Dewitte, Elise Scheers   +2 more
doaj   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Resistify: A Novel NLR Classifier That Reveals Helitron-Associated NLR Expansion in Solanaceae

Bioinformatics and Biology Insights
Nucleotide-binding domain leucine-rich repeat (NLR) proteins are a key component of the plant innate immune system. In plant genomes, NLRs exhibit considerable presence/absence variation and sequence diversity. Recent advances in sequencing technologies have made the generation of high-quality novel plant genome assemblies considerably more ...
Moray Smith, John T Jones, Ingo Hein
openaire   +5 more sources

Rosetta Stone of NLR Innate Immunity [PDF]

Trends in Biochemical Sciences, 2016
The formation of NLR inflammasomes is a central step in the initiation of the innate immune response. Two recent publications describe the structure of the NAIP2-NLRC4 inflammasome and derive an elegant model of NLR inflammasome formation, whereby binding of the pathogen-molecule-bound NLR NAIP2 to NLRC4 leads to the activation of NLRC4 and initiation ...
Bernhard C, Lechtenberg, Stefan J, Riedl
openaire   +2 more sources

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Effect of sowing methods and sowing rate in organic seed production of timothy (Phleum pratense L.), meadow fescue (Festuca pratensis Huds.) and red clover (Trifolium pratense L.)

Acta Agriculturae Scandinavica. Section B, Soil and Plant Science, 2017
Different sowing methods and sowing rates were evaluated in organic seed production of timothy (two trials), meadow fescue (two trials) and red clover (one trial) in Southeast Norway, during 2010–2013.
Lars T. Havstad, John Ingar Øverland
doaj   +1 more source