Results 81 to 90 of about 192,001 (267)

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Comparative Investigation of Radiation-Driven Failure Mechanisms in Photonic–Electronic Optical Communication Terminals Across Earth Orbits

IEEE Access
Optical Communication Terminals (OCTs) integrate photonic and electronic technologies to enable high-speed, secure, and interference-free space communication.
Jasper Dijks, Sybren De Jong, Alessandra Menicucci, Iklim Akay, Niels Donkers   +4 more
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Concept Evaluation of Radical Short–Medium-Range Aircraft with Turbo-Electric Propulsion

Aerospace
Ambitious targets for the coming decades have been set for further reductions in aviation greenhouse gas emissions. Hybrid electric propulsion (HEP) concepts offer potential for the mitigation of these aviation emissions. To investigate this potential in
W. J. Vankan, W. F. Lammen, E. Scheers, P. J. Dewitte, Sebastien Defoort   +4 more
doaj   +1 more source

Inflammatory Markers in Women with Infertility: A Cross-Sectional Study

International Journal of General Medicine, 2023
Yanan Duan,1 Ye Zhou,2 Yiqing Peng,2 Xiuling Shi,2 Cunxu Peng2 1Jining Medical University, Jining, Shandong Province, 272002, People’s Republic of China; 2Department of Gynecology, Affiliated Hospital of Jining Medical University, Jining, Shandong ...
Duan Y, Zhou Y, Peng Y, Shi X, Peng C
doaj  

Pharmacogenomic profiling of the efficacy of gemcitabine monotherapy in metastatic pancreatic cancer: Subgroup analysis of the GENESECT study

British Journal of Clinical Pharmacology, EarlyView.
Aim In the GENESECT study, no significant gemcitabine (GEM) metabolism‐related germline genetic polymorphisms (GPs) were identified because approximately 70% of patients received combination therapy with nab‐paclitaxel, which has metabolic pathways different from GEM.
Takashi Yokokawa, Daiki Tsuji, Masahiro Hatori, Kazuyoshi Kawakami, Masahiko Nakao, Takuya Yano, Yuichiro Arakawa, Keisuke Matsuo, Yasukata Ohashi, Masato Ozaka, Naoki Sasahira, Yasuhiko Sakata, Yuki Kogure, Shinya Tamaki, Atsushi Wada, Yusuke Taki, Wataru Suzuki, Kazuo Kobayashi, Hiroshi Ishii, Kunihiko Itoh, Masakazu Yamaguchi, Kenichi Suzuki   +21 more
wiley   +1 more source

The NLR SkinApp: Testing a Supporting mHealth Tool for Frontline Health Workers Performing Skin Screening in Ethiopia and Tanzania

Tropical Medicine and Infectious Disease
Background: The prevalence of skin diseases such as leprosy, and limited dermatological knowledge among frontline health workers (FHWs) in rural areas of Sub-Saharan Africa, led to the development of the NLR SkinApp: a mobile application (app) that ...
Nelly Mwageni, Robin van Wijk, Fufa Daba, Ephrem Mamo, Kitesa Debelo, Benita Jansen, Anne Schoenmakers, Colette L. M. van Hees, Christa Kasang, Liesbeth Mieras, Stephen E. Mshana   +10 more
doaj   +1 more source

Neutrophil/Lymphocyte Ratio (NLR) and Lymphocyte/Monocyte Ratio (LMR) – Risk of Death Inflammatory Biomarkers in Patients with COVID-19

Journal of Inflammation Research, 2023
Violetta Dymicka-Piekarska,1,* Justyna Dorf,1,* Anna Milewska,2 Mateusz Łukaszyk,3 Jakub Wiktor Kosidło,4 Joanna Kamińska,1 Blanka Wolszczak-Biedrzycka,5 Wojciech Naumnik3 1Department of Clinical Laboratory Diagnostics ...
Dymicka-Piekarska V, Dorf J, Milewska A, Łukaszyk M, Kosidło JW, Kamińska J, Wolszczak-Biedrzycka B, Naumnik W   +7 more
doaj  

Assembly of helper NLR resistosome clusters upon activation of a coiled-coil NLR

Nature
Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors detect pathogen effectors and activate immunity1. Coiled-coil NLRs (CNLs) form resistosomes as Ca2+-permeable channels in the plasma membrane (PM)2-4. However, the mechanism by which resistosomes activate cell death remains unclear. Here we report that the CNL SUPPRESSOR OF mkk1 mkk2 2
Dongdong Ge, Fausto Andres Ortiz-Morea, Yingpeng Xie, In-Cheol Yeo, Qiaochu Shen, Yulu Zhou, Guangchao Liu, Liang Kong, Libo Shan, Ping He   +9 more
openaire   +2 more sources

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source