Inflammatory Stewardship—A Perspective for Active Management of Acute Inflammation
The FASEB Journal, Volume 40, Issue 12, 30 June 2026.Inflammatory stewardship frames inflammation as a manageable clinical domain requiring explicit strategy, governance, and feedback. It aligns diagnostics, risk stratification, biomarker interpretation, and immunomodulatory decisions across perioperative and critical‐care teams.
Lennart Finn Herrlich +2 more
wiley +1 more source
NLR family pyrin domain containing 3 (NLRP3; NALP3) [PDF]
Science-Business eXchange, 2010 openaire +3 more sources
Peroxiredoxin 1 inhibits tumorigenesis by activating the NLR family pyrin domain containing 3/gasdermin D pathway: Advanced therapies targeting heterogeneous cell death mechanisms. [PDF]
World J GastroenterolSmirnova A +4 more
europepmc +1 more source
PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway. [PDF]
Front Aging Neurosci, 2021 Samidurai M +10 more
europepmc +1 more source
Beyond Hemostasis: Platelet Biomarkers and Vascular‐Immune Crosstalk in Dengue
The FASEB Journal, Volume 40, Issue 12, 30 June 2026.Several biomarkers are associated with platelet activation during dengue virus (DENV) infection. These include serum markers (AST, ALT, ferritin), platelet surface or secreted molecules (P‐selectin, PF4, RANTES, VEGF‐A, CD40L, TREM‐1, TLT‐1), immune and endothelial markers (TREM‐1, Ang‐1, Ang‐2), and viral components such as DENV EIII.
Amanda Beatriz Adriano da Silva‐Alencar +6 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 11, 15 June 2026.Piper corcovadensis extract is rich in bioactive compounds with antioxidant potential, capable of decreasing ROS levels; antitumor activity in cutaneous melanoma cells SK‐MEL‐28; and anti‐inflammatory activity, decreasing the expression of IL‐6 and NLPR3 genes and increasing TNF expression, without cytotoxicity to healthy peripheral blood cells (PBMCs).
Bruno Henrique Fontoura +7 more
wiley +1 more source
Phospholipid signaling regulation is a property of the NLR family gene NLRP7.
Phospholipid signaling control by NLRP7 included regulation of inositol triphosphate gene activation and control of genes functioning in phospholipid biosynthesis.
openaire +2 more sources
Advanced Science, Volume 13, Issue 31, 4 June 2026.RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
wiley +1 more source
Insights into the structure of NLR family member X1: Paving the way for innovative drug discovery. [PDF]
Comput Struct Biotechnol JJewell S +3 more
europepmc +1 more source
Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer
Advanced Science, Volume 13, Issue 35, 24 June 2026.Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen +13 more
wiley +1 more source