Results 171 to 180 of about 90,508 (248)

Performance of Machine Learning Models Based on Medical Imaging in Predicting Pathological Grade of Clear Cell Renal Cell Carcinoma

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background Predicting clear cell renal cell carcinoma (ccRCC) pathological grade preoperatively is critical for clinical management. This study aims to evaluate the diagnostic accuracy and clinical utility of machine learning (ML)‐based imaging models.
Yuchao Wang, Zhuwei Song, Zhaonan Hou, Yihao Chen, Shouyuan Liu, Chunyu Chen, Haoyun Guan, Zhengyang Pang, Songchen Yan, Zhiyu Zhang, Ruijia Tu, Gang Zhu, Xiantao Zeng, Bo Fan   +13 more
wiley   +1 more source

Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes. [PDF]

Eur J Med Res
Chen F, Xing Y, Chen Z, Chen X, Li J, Gong S, Luo F, Cai Q.   +7 more
europepmc   +1 more source

Assembly and Activation of the NLR Family in Innate Immune Regulation and Cell Death

The nucleotide-binding oligomerization domain (NOD)-like receptor, also known as nucleotide-binding leucine-rich repeat receptors (NLRs), are evolutionarily conserved intracellular sensors critical for detecting pathogen- and damage-associated signals.
openaire   +1 more source

Classification, Structure–Activity Relationship, and Anti‐Osteoarthritis Mechanism of Natural Flavonoids

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Natural product flavonoids have a multi‐target therapeutic intervention effect on osteoarthritis. They promote autophagy and cartilage synthesis while alleviating oxidative stress, inhibiting inflammation, and inhibiting matrix degradation. By restoring OPG/RANKL balance and regulating bone metabolism, these compounds synergistically delay the ...
Haibin Wang, Shuqi Zheng, Chunlei Hua, Wanze Feng, Zengxia Liu, Yanhong Sun, Minhui Li   +6 more
wiley   +1 more source

The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways. [PDF]

Med Sci Monit, 2020
Zhou J, Zhang F, Lin H, Quan M, Yang Y, Lv Y, He Z, Qian Y.   +7 more
europepmc   +1 more source

Left Atrium and Left Atrial Appendage Remodeling Assessed by Echocardiography Predict Atrial Fibrillation Recurrence After Radiofrequency Catheter Ablation

Clinical Cardiology, Volume 49, Issue 9, September 2026.
LAAS and LAASR were independent factors contributing to AF recurrence. Incremental value of LAAS and LAASR in risk prediction of AF recurrence. ABSTRACT Purpose The aim of this study is to evaluate left atrium (LA) and left atrial appendage (LAA) remodeling using two‐dimensional speckle tracking echocardiography (2D‐STE) and investigate its predictive ...
Binyang Zhu, Shaohui Qu, Hairu Li, Dandan Yu, Yingying Liu, Xin Ai, Guangyin Li, Shuangquan Jiang   +7 more
wiley   +1 more source

NLR family pyrin domain containing 3 (NLRP3; NALP3) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Modulating the Gut‐Microbiota‐Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review systematically examines the role of gut microbiota modulation in Alzheimer's disease, focusing on how microbial metabolites and dietary nutrients influence cognitive function and AD pathology, as well as the neuroprotective effects through the gut‐brain axis.
Binyue Xu, Xuhuan Li, Shangling Dong, Zheyuan Zhang, Dong Jin, Guoping Li, Jiesheng Wang   +6 more
wiley   +1 more source

Association Between Multiple Inflammation‐Derived Indices and the Risk of Post‐Stroke Epilepsy

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This propensity score‐matched case–control study (n = 634) evaluated six inflammation‐derived indices for post‐stroke epilepsy risk stratification. SIRI demonstrated the strongest association (OR = 2.72, 95% CI: 2.04–3.63), moderate discriminative ability (AUC = 0.693), and robustness to unmeasured confounding (E‐value = 4.88). ABSTRACT Background Post‐
Yu Wang, YeQin Gao, Long Wang
wiley   +1 more source

Mechanisms and Predisposing Conditions for Statin‐Induced New‐Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley   +1 more source