A basic function of the NLR family is control and detection of neuropeptide expression.
Quantity of gene product present in the cell is strictly held under transcriptional control. Molecules with bioactive properties, like neuropeptides involved in feeding, anxiety and social behaviors, may be guarded at the level of quantity through distinct mechanisms to prevent ensuing disease related to or based on derestricted function of the guarded
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Ralstonia solanacearum suppresses P450 activity to block VA‐to‐VanA conversion, leading to VA accumulation and compromised immunity. ABSTRACT Soil acidification often exacerbates plant diseases caused by soil‐borne pathogens like Ralstonia solanacearum, but the underlying molecular mechanisms remain elusive. This study unveils a sophisticated metabolic
Hua Wang +10 more
wiley +1 more source
Abstract Although seed represents an important means of plant pathogen dispersion, the seed–pathogen dialogue remains largely unexplored. A multiomic approach was performed at different seed developmental stages of common bean (Phaseolus vulgaris L.) during asymptomatic colonization by Xanthomonas citri pv.
Armelle Darrasse +6 more
wiley +1 more source
miR-23a-5p Alleviates Gouty Inflammation by Targeting Interleukin-17A and Inhibiting NLR Family Pyrin Domain Containing 3 Inflammasome Activation. [PDF]
Yuan X, Lin C, Zhang Y, He H, Li L.
europepmc +1 more source
Knock-down of microRNA miR-556-5p increases cisplatin-sensitivity in non-small cell lung cancer (NSCLC) via activating NLR family pyrin domain containing 3 (NLRP3)-mediated pyroptotic cell death. [PDF]
Shi F, Zhang L, Liu X, Wang Y.
europepmc +1 more source
ABSTRACT Pulses provide myriad health benefits and are advantageous in an environmental context as a result of their leguminous nature. However, phytopathogenic fungi, oomycetes and bacteria pose a substantial threat to pulse production, at times leading to crop failure.
Stacy D. Singer +6 more
wiley +1 more source
ABSTRACT Plant viruses cause significant crop losses, a situation that could worsen due to anthropogenic activities driving global climate change, one factor of which is the increase in atmospheric CO2 concentration. This study assessed the impact of elevated CO2 concentration (eCO2, 1000 vs. 400 ppm) on two genotypes of common bean (Phaseolus vulgaris
Tiffanie Scandolera +12 more
wiley +1 more source
Celastrol alleviates esophageal stricture in rats by inhibiting NLR family pyrin domain containing 3 activation. [PDF]
Zhang MX +7 more
europepmc +1 more source
Apurinic/apyrimidinic endonuclease 1/reduction-oxidation effector factor-1 (APE1) regulates the expression of NLR family pyrin domain containing 3 (NLRP3) inflammasome through modulating transcription factor NF-κB and promoting the secretion of inflammatory mediators in macrophages. [PDF]
Tang Z +8 more
europepmc +1 more source
NLR family, CARD domain containing 5 (NLRC5) [PDF]
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