Activation and Autoinhibition Mechanisms of NLR Immune Receptor Pi36 in Rice
International Journal of Molecular SciencesNucleotide-binding and leucine-rich repeat receptors (NLRs) are the most important and largest class of immune receptors in plants. The Pi36 gene encodes a canonical CC-NBS-LRR protein that confers resistance to rice blast fungal infections. Here, we show that the CC domain of Pi36 plays a role in cell death induction.
Yang, Yang +13 more
openaire +2 more sources
Constipation Is Linked to Neuroinflammation in Early Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background Constipation is a risk factor for the onset and accelerated progression of Parkinson's disease (PD), but the mechanisms underlying this association are unknown. Neuroinflammation in PD has been demonstrated in postmortem and neuroimaging studies; however, its relationship with constipation has not been investigated.
Marta Camacho +8 more
wiley +1 more source
Calcium signaling in plant defense
New Plant Protection, EarlyView.Calcium signaling acts as a central hub in plant immunity, translating pathogen perception into defense responses. This review highlights the channels, sensors, and signaling networks involved, and discusses how pathogens subvert calcium dynamics, as well as how this knowledge may inspire innovative strategies for engineering durable crop resistance ...
Lifan Sun, Yu Wang, Jie Zhang
wiley +1 more source
Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components [PDF]
, 2015 Rongrong Liu +8 more
openalex +1 more source
Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis
PROTEOMICS, EarlyView.ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan +5 more
wiley +1 more source
Sleep Research, EarlyView.Abstract Objective To assess sleep quality and its influencing factors in patients with chronic heart failure (CHF). Methods A study of 112 CHF patients was conducted using the Pittsburgh Sleep Quality Index (PSQI). Clinical and socio‐demographic data were collected.
Meng‐Dan Chu +6 more
wiley +1 more source
A Caterpiller molekulák szerepe a szaruhártya természetes immunitásának kialakításában = The role of Caterpiller molecules in the innate immunity of the cornea [PDF]
, 2011 Munkánk során humán korneális epitélsejteken és keratinocitákon vizsgáltuk az intracelluláris mintázatfelismerő Nod-like receptor (NLR) család expresszióját és a fehérjék lehetséges szerepét.
Benkő, Szilvia
core
NRG1 is required for the function of the TIR-NLR immune receptors Roq1 and RPP1 in Nicotiana. benthamiana [PDF]
, 2018 Tiancong Qi +4 more
openalex +1 more source
A genetically linked pair of NLR immune receptors shows contrasting patterns of evolution
, 2022 Motoki Shimizu +13 more
openalex +2 more sources
The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li +4 more
wiley +1 more source