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Ovarian cancer metastatic to the breast
Gynecologic Oncology, 1986The breast is an uncommon site for metastasis from epithelial ovarian cancer. Such lesions are purportedly secondary to blood-borne metastases. The accurate classification of ovarian epithelial neoplasms is the cornerstone of decisions regarding therapy and prognosis.
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Treatment of metastatic breast cancer
Seminars in Oncology Nursing, 1991Relapse of breast cancer connotes a dire prognosis. However, long-term survival with remissions and disease exacerbation are possible using conservative treatment strategies and often sequential hormonal manipulations. Hormonal therapy is the mainstay of metastatic breast cancer treatment for patients with hormonally sensitive tumors; cytotoxic ...
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Metastatic view of breast cancer
Cancer and Metastasis Reviews, 2012The ancient view regarding breast cancer as a metastasis has not been supported so far by experimental evidence. We have implanted nephroblastoma tumor cells resulting in a rat metastatic kidney capsule-parathymic lymph node (PTN) model. India ink implantation confirmed the lymphatic connection between the primary tumor of the kidney and PTNs.
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Therapy for metastatic breast cancer
Current Opinion in Oncology, 1994Our understanding of mechanisms of resistance to endocrine treatment has increased; they include mutations in steroid receptors and altered metabolism of tamoxifen. Tamoxifen and progestogens appear to have similar efficacies for first-line endocrine treatment, but high doses of progestogens have been shown to give less cost-effective results compared ...
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Treatment of Metastatic Breast Cancer
Journal of the National Comprehensive Cancer Network, 2014Many newer agents in combination are being studied in the front-line treatment of women with HER2-positive metastatic breast cancer (MBC), but the story in the endocrine arena is more about the wise use of new strategies to overcome endocrine resistance, because no new antihormonal agents have been approved in the past decade.
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The biology of metastatic breast cancer
Cancer, 1990Early detection and surgical removal of breast cancer are most effective in managing a disease that may affect up to one in ten women in North America and Western Europe. However, one of the most important prognostic indicators for breast cancer is the presence of neoplastic cells in the axillary lymph nodes.
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Cutaneous Metastatic Breast Cancer
Clinical Journal of Oncology Nursing, 2002Breast cancer is the most commonly diagnosed cancer in women and the second leading cause of cancer deaths among women in the United States. Many women diagnosed with breast cancer will achieve a cure with surgery followed by adjuvant chemotherapy, hormonal therapy, or radiation therapy; however, some breast cancer survivors will develop locally ...
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Update on metastatic breast cancer
Current Oncology Reports, 1999Although the great majority (80%) of patients diagnosed with breast cancer have disease that is limited to a locoregional area (breast and/or axillary lymph nodes), almost half of them eventually develop metastatic disease. An extensive array of basic and clinical research has been performed throughout the last decade in an attempt to improve the ...
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Gemcitabine in metastatic breast cancer
Expert Review of Anticancer Therapy, 2005Gemcitabine is a pyrimidine antimetabolite which has shown activity in metastatic breast cancer both as a single agent, but also in various combination regimens. It is characterized by a unique mechanism of action which includes cytotoxic self-potentiation, masked DNA chain termination and potent inhibition of DNA repair.
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