Results 171 to 180 of about 1,342,871 (301)

Perspectives of NLR aeroelastic methods to predict wing/store flutter and dynamic loads of fighter-type aircraft [PDF]

open access: yes, 2000
Meijer, J.J.   +4 more
core  

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

open access: yesCancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang   +6 more
wiley   +1 more source

The E3 Ligase APIP10 Connects the Effector AvrPiz-t to the NLR Receptor Piz-t in Rice. [PDF]

open access: yesPLoS Pathog, 2016
Park CH   +12 more
europepmc   +1 more source

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

open access: yesCancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang   +6 more
wiley   +1 more source

Limitations of PIV Biomarker Analysis Related to Chemoradiotherapy and Unadjusted Confounders

open access: yesCancer Science, EarlyView.
The pan‐immune‐inflammation value (PIV) derived from four blood cell counts warrants cautious interpretation in rectal‐cancer immunotherapy, as CRT cannot be disentangled from anti‐PD‐1 effects within the small n = 16 subgroup.
Hongbo Gao, Wencai Weng
wiley   +1 more source

Long Non‐Coding RNA, Like NEAT1 and MALAT1, in Asthma: Mechanisms and Therapeutic Potential

open access: yesClinical &Experimental Allergy, EarlyView.
Long non‐coding RNA, like NEAT1 and MALAT1, is emerging as a regulator of asthma‐related inflammation, airway remodelling, viral responses and cell death pathways, and are promising targets for future therapeutics. ABSTRACT Asthma affects millions worldwide. Long non‐coding RNA (lncRNA) are emerging as important factors in the pathophysiology of asthma
Ashlyn Poole   +4 more
wiley   +1 more source

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