Results 91 to 100 of about 1,232,647 (277)

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Generalized inverse scattering transform for the nonlinear Schrodinger equation for bound states with higher multiplicities

Electronic Journal of Differential Equations, 2017
We consider a generalization of the inverse scattering transform for the nonlinear Schrodinger (NLS) equation when bound states have multiplicities greater than one.
Theresa N. Busse Martines
doaj  

On Origin and Dynamics of the Discrete NLS Equation

, 2000
"We investigate soliton-like dynamics in the descrete nonlinear Schroedinger equation (DNLSE) describing the generic 3-element descrete nonlinear system with a dispersion.
"Hadzievski, L., Sato, T.", Skoric, M.M.   +2 more
core  

Twenty Parameters Families of Solutions to the NLS Equation and the Eleventh Peregrine Breather

, 2016
International audienceThe Peregrine breather of order eleven (P11 breather) solution to the focusing one-dimensional nonlinear Schrödinger equation (NLS) is explicitly constructed here.
Gaillard, Pierre, Gastineau, Mickael
core   +1 more source

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

Analyzing nonlinear Schrödinger equations by the complex variable element-free Galerkin method

Open Mathematics
This article proposes a complex variable element-free Galerkin (CVEFG) method for analyzing the nonlinear Schrödinger (NLS) equation. A second-order accurate scheme is presented to achieve temporal discretization and linearize the nonlinear term, and the
Liu ZhiXiu
doaj   +1 more source

Justification of the NLS Approximation for the KdV Equation Using the Miura Transformation

Advances in Mathematical Physics, 2011
It is the purpose of this paper to give a simple proof of the fact that solutions of the KdV equation can be approximated via solutions of the NLS equation.
Guido Schneider
doaj   +1 more source

Soliton Solution of Schrödinger Equation Using Cubic B-Spline Galerkin Method

Fluids, 2019
The non-linear Schrödinger (NLS) equation has often been used as a model equation in the study of quantum states of physical systems. Numerical solution of NLS equation is obtained using cubic B-spline Galerkin method.
Azhar Iqbal, Nur Nadiah Abd Hamid, Ahmad Izani Md. Ismail   +2 more
doaj   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source