Results 141 to 150 of about 54,863 (259)

Intra‐annual energy density cycles of spring‐ and fall‐spawning Atlantic herring Clupea harengus reveal different reproductive allocation tactics

Journal of Fish Biology, EarlyView.
Abstract Atlantic herring Clupea harengus are total spawners that exhibit a large degree of reproductive plasticity and have substantial intra‐annual variation in their energetic condition. Recent research suggests that the species may be declining in energetic condition in the northwest Atlantic Ocean from the few historical records, but comparisons ...
Joseph B. Warren, Mark J. Wuenschel, Kenneth Oliveira   +2 more
wiley   +1 more source

Serial Spatial Transcriptomes Reveal Regulatory Transitions in Maize Leaf Development

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant leaves originate from the shoot apical meristem (SAM) and undergo a developmental process of highly coordinated gene expression regulation. To date, only a few key regulators have been identified and characterised, so the gene expression cascades responsible for leaf cell specification and differentiation from SAM remain largely elusive.
Chi‐Chih Wu, Ludvig Larsson, Kun‐Ting Hsieh, Chun‐Ping Yu, Yi‐Hua Chen, Kai‐Hsuan Ding, Ho‐Chun Yang, Joakim Lundeberg, Chin‐Min Kimmy Ho, Shu‐Hsing Wu, Mei‐Yeh Jade Lu, Wen‐Hsiung Li   +11 more
wiley   +1 more source

Prevention of Atopic Dermatitis in High‐Risk Infants: A Review of the Role of Lipid‐Based Barrier Repair Therapy

Pediatric Dermatology, EarlyView.
ABSTRACT Background/Objective Growing evidence highlights the role of physiological lipids, namely ceramides, cholesterol, and free fatty acids, in maintaining skin barrier function and preventing atopic dermatitis (AD). Current evidence on the efficacy, safety, and clinical relevance of stratum corneum (SC) lipid‐based therapies to prevent AD and ...
Chon‐Wai Jeremy Chan, Marty O. Visscher   +1 more
wiley   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source

Non-negative matrix factorization with sparseness constraints

, 2004
Non-negative matrix factorization (NMF) is a recently developed technique for finding parts-based, linear representations of non-negative data. Although it has successfully been applied in several applications, it does not always result in parts-based ...
Patrik O. Hoyer, Peter Dayan
core   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Simultaneous and Proportional Control Based on an Enhanced Musculoskeletal Model

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Recently, the musculoskeletal model (MM) has been widely studied for decoding movement intent from electromyography (EMG) signals. However, the decoding performance of the MM is impaired for the coordinated movements of multiple degrees of freedom (DoFs)
Lizhi Pan, Diyi Liu, Ruyi Wang, Jinhua Li   +3 more
doaj   +1 more source

Multiomics Research Strategies in Cancer: A Growing and Innovative Field

MedComm, Volume 7, Issue 4, April 2026.
This review highlights multiomics strategies in cancer research, focusing on integration methods from genomics to microbiomics. Using colorectal cancer as a key example, it discusses biomarker discovery, data integration via deep learning, and the roles of single‐cell and spatial omics.
Zhenhua Du, Xiaomei Liu, Zhi Lv, Bengang Wang, Yu Xia, Wala Abduljabbar Mohammed Al‐Duais, Lirong Yan, Fuqiang Zhang, Yanke Li   +8 more
wiley   +1 more source

Testing Hypotheses of Covariate Effects on Topics of Discourse

Statistical Analysis and Data Mining: An ASA Data Science Journal, Volume 19, Issue 2, April 2026.
ABSTRACT We introduce an approach to topic modeling with document‐level covariates that remains tractable in the face of large text corpora. This is achieved by de‐emphasizing the role of parameter estimation in an underlying probabilistic model, assuming instead that the data come from a fixed but unknown distribution whose statistical functionals are
Gabriel Phelan, David A. Campbell
wiley   +1 more source

Artificial intelligence streamlines scientific discovery of drug–target interactions

British Journal of Pharmacology, Volume 183, Issue 8, Page 1673-1690, April 2026.
Abstract Drug discovery is a complicated process through which new therapeutics are identified to prevent and treat specific diseases. Identification of drug–target interactions (DTIs) stands as a pivotal aspect within the realm of drug discovery and development. The traditional process of drug discovery, especially identification of DTIs, is marked by
Yuxin Yang, Feixiong Cheng
wiley   +1 more source