Results 161 to 170 of about 55,457 (295)

Immune endotypes in tuberculosis: Keys to decoding disease complexity

Journal of Internal Medicine, Volume 299, Issue 6, Page 670-693, June 2026.
Abstract Tuberculosis (TB) remains a major global health challenge, with multi‐drug antibiotic regimens as the current standard of care. While effective at killing Mycobacterium tuberculosis, these treatments do not resolve persistent inflammation, prevent lung damage, or reverse immune dysregulation that contribute to poor outcomes and disease ...
Shamila D. Alipoor, Julia Guthrie, Lina Davies Forsman, Andrew R. Di Nardo, Susanna Brighenti   +4 more
wiley   +1 more source

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease

Advanced Science, Volume 13, Issue 25, 4 May 2026.
This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao, Jianjun Zou, Chen Zhou, Yingui Wang, Yiman Liu, Yanqing Zhou, Yuxiang Wang, Xinyu Zhang, Huishu Yang, Hongjie Yin, Dongsheng Bai, Yue Zhao, Na Lu   +12 more
wiley   +1 more source

Fairer non-negative matrix factorization. [PDF]

Front Big Data
Kassab L, George E, Needell D, Geng H, Jafar Nia N, Li A.   +5 more
europepmc   +1 more source

Niacin promotes motor function recovery after spinal cord injury via Hcar2‐dependent microglia immunometabolic regulation

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• The activation of the microglial Hcar2 receptor by niacin initiates intracellular signalling that induces metabolic reprogramming. • This metabolic shift is characterized by increased oxidative phosphorylation. Consequently, microglia polarize from a proinflammatory state toward an anti‐inflammatory, reparative phenotype.
Hua Du, Lingnian Zeng, Chan Liu, Huyao Zhou, Xia Wang, Qing Ai, Jinpiao Zhu, Nong Xiao   +7 more
wiley   +1 more source

Recovering missing features in nonnegative matrix factorization via generalized singular value decomposition. [PDF]

iScience
Guo Y, Holy TE.
europepmc   +1 more source

Hemisphere‐Level Comparison of Climate‐Driven Humpback Whale Breeding Migrations to the Eastern Pacific Off Costa Rica

Ecology and Evolution, Volume 16, Issue 5, May 2026.
This study analyzed humpback whale occurrence off the Pacific coast of Costa Rica from 2001 to 2023, focusing on the Central America and Southeast Pacific Distinct Population Segments, using long‐term sightings and Bayesian time‐series and habitat models.
Lili Pelayo‐González, Mario A. Pardo, Enrique Martínez‐Meyer, David Herra‐Miranda, Juan D. Pacheco‐Polanco, Sierra Goodman, Lenin Oviedo   +6 more
wiley   +1 more source

JGR-NMF: joint graph-regularized non-negative matrix factorization for spatial domain identification. [PDF]

PeerJ
Liang J, Huang J, Xi C, Wang Y, Li J.
europepmc   +1 more source

AlphaFold‐driven discovery of oxysterol‐binding protein‐related protein‐phosphoinositide 3‐, 4‐, and 5‐phosphatase interactions using new generation confidence scores

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Non‐vesicular lipid transport contributes to the regulation of membrane composition and organelle function at membrane contact sites. OSBP‐related proteins (ORPs) are central to this process, yet their interaction networks remain incompletely defined. Here, we systematically screened potential interactions between ORPs and phosphoinositide 3‐,
Filippo Dall'Armellina, Sylvie Urbé, Daniel J. Rigden   +2 more
wiley   +1 more source

Ultrasonography and the Reorientation of Developmental Hip Dysplasia Research: An NLP-NMF Trend Analysis (1980-2024). [PDF]

Eurasian J Med
Taşkin R, Yılar S, Budak İ, Uğur F.
europepmc   +1 more source

The Decline of Humpback Whales in Prince William Sound, Alaska, Following the 2014–2016 Northeast Pacific Marine Heatwave

Marine Mammal Science, Volume 42, Issue 3, July 2026.
John R. Moran, Janice M. Straley, Jacek M. Maselko, Lauren A. Wild, Robert M. Suryan   +4 more
wiley   +1 more source